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Missouri

Office

Mississippi County, MO Office Spaces for Sale

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Kansas City, MO Springfield, MO Louis, MO Joplin, MO Saint Louis, MO Branson, MO West Plains, MO St Joseph, MO

Subdividable Corner Retail-Office Building

Updated: Dec 15, 2025

Subdividable Corner Retail-Office Building

201-203 E. Pine, East Prairie, MO 63845

$185,000

9,700 sqft 0.44 AC lot

Brick retail/office producing building built in 1972 with 9,700 SF of space
Corner lot with visibility from both streets and strong exterior presence
Approximately 20‑car parking and 8–10 overhead doors for deliveries or loading needs
Open area measures 68'–72' with 10' ceiling height
Building can be subdivided for offices or used as a retail store

Commercial Building with Highway Frontage

Updated: Apr 10, 2025

Commercial Building with Highway Frontage

1113 E. Marshall, Charleston, MO 63834

$99,900

2,121 sqft

Commercial building with over 2,100 SF, formerly Johnnie's Drive‑In, ready for renovation for retail or office use
Over 300' of highway frontage on East Marshall Street with traffic exposure
2+ acres of land for additional commercial use
Built in 1947 with forced‑air heating and central AC
About 1 mile from I‑57 in Charleston

Retail Building with Office Back Area

Retail Building with Office Back Area

2380 S. Main, Charleston, MO 63834

$84,000

1,452 sqft 0.73 AC lot

Retail building offers two offices, open floor space, and a half bath, with a large lot for expansion.

Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center

Based on your search, we've compiled 76 Potential Opportunities for your consideration. Besides 3 Active listings in Mississippi County, MO, we suggest exploring several alternatives: similar 69 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Commercial Development Land Parcel

Commercial Development Land Parcel

224 S Interstate Drive, Sikeston, MO 63801

$199,000

2.00 AC lot

A 2-acre commercial lot in Sikeston, MO, available for a build-to-suit development under commercial zoning.

Vacant Commercial Land Lot

Vacant Commercial Land Lot

116 Hospitality Drive, Sikeston, MO 63801

$195,000

0.72 AC lot

Vacant, level commercial-zoned lot outside the flood plain, suitable for a future development footprint.

Commercial Development Land Site

Commercial Development Land Site

103 Grove Estates, Sikeston, MO 63801

$144,000

1.01 AC lot

Commercially zoned tract with Highway 61 frontage for office, medical, and professional services near Sikeston residential areas.

Renovated Downtown Office and Retail Building

Renovated Downtown Office and Retail Building

230 N Sprigg Street, Cape Girardeau, MO 63701

$239,900

2,937 sqft 0.25 AC lot

Renovated commercial building on a high-traffic downtown corridor, offering flexible space for offices or storefront services.

Off-Market Properties in Mississippi County, MO

Consider similar Off-Market properties in Mississippi County, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

OFFICE (GENERAL)

115 Main St, Charleston, MO 63834-1632

Value Estimation by Request

4,453 sqft 0.39 AC lot

801 Marshall St

OFFICE (GENERAL)

801 Marshall St, Charleston, MO 63834-1262

Value Estimation by Request

7,032 sqft 0.33 AC lot

OFFICE (GENERAL)

204 1st St, Charleston, MO 63834-1100

Value Estimation by Request

1,664 sqft 0.10 AC lot

208 Commercial St

OFFICE (GENERAL)

208 Commercial St, Charleston, MO 63834-1749

Value Estimation by Request

2,150 sqft 0.16 AC lot

109 Commercial St

OFFICE (GENERAL)

109 Commercial St, Charleston, MO 63834-1728

Value Estimation by Request

520 sqft 0.02 AC lot

MEDICAL BUILDING

2402 Main St, Charleston, MO 63834-8318

Value Estimation by Request

7,833 sqft 1.51 AC lot

OFFICE (GENERAL)

3343 Hwy 80, East Prairie, MO 63845-9194

Value Estimation by Request

614 sqft 13.60 AC lot

OFFICE (GENERAL)

3980 Hwy 80, East Prairie, MO 63845-8972

Value Estimation by Request

907 sqft 0.52 AC lot

OFFICE (GENERAL)

208 Main St, Charleston, MO 63834-1640

Value Estimation by Request

2,137 sqft 0.23 AC lot

OFFICE (GENERAL)

307 Main St, East Prairie, MO 63845-1125

Value Estimation by Request

1,165 sqft 0.15 AC lot

OFFICE (GENERAL)

831 Hwy 105, Charleston, MO 63834-8371

Value Estimation by Request

4,698 sqft 3.00 AC lot

OFFICE (GENERAL)

1300 Plant Rd, Charleston, MO 63834-2375

Value Estimation by Request

8,338 sqft 19.34 AC lot

OFFICE (GENERAL)

905 Main St, East Prairie, MO 63845-8133

Value Estimation by Request

1,920 sqft 2.04 AC lot

OFFICE (GENERAL)

219 Main St, East Prairie, MO 63845-1123

Value Estimation by Request

2,878 sqft 0.08 AC lot

625 Washington St

OFFICE (GENERAL)

625 Washington St, East Prairie, MO 63845-1823

Value Estimation by Request

1,133 sqft

1110 Marshall St

OFFICE (GENERAL)

1110 Marshall St, Charleston, MO 63834-1353

Value Estimation by Request

2,688 sqft 1.44 AC lot

County Rd 326-barnsgbs

OFFICE (GENERAL)

County Rd 326-barnsgbs, Charleston, MO 63834

Value Estimation by Request

672 sqft 2.38 AC lot

MEDICAL BUILDING

400 Main St, Charleston, MO 63834-1644

Value Estimation by Request

3,215 sqft 0.17 AC lot

913 Washington St

OFFICE (GENERAL)

913 Washington St, East Prairie, MO 63845-1052

Value Estimation by Request

2,514 sqft 0.90 AC lot

405 407th E Main-offic

OFFICE (GENERAL)

405 407th E Main-offic, East Prairie, MO 63845

Value Estimation by Request

1,298 sqft

611 633rd S Hwy

OFFICE (GENERAL)

611 633rd S Hwy, East Prairie, MO 63845

Value Estimation by Request

973 sqft 4.00 AC lot

Mississippi County, MO Office Spaces Market Trends and Statistics

Explore 72 office spaces for sale in Mississippi County, MO, showcased through 3 active listings on our real estate platform. These investment opportunities span a total of 13,273 square feet of properties for sale, with an estimated market value of $368,900.

Sale prices for office spaces in Mississippi County, MO start at $84,000, averaging $122,966, and reaching up to $185,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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