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    De Soto, MO Commercial Real Estate for Sale

    11 results
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    Established Tire Business with Real Estate
    Pending
    $115,000
    2,541 SF

    Established Tire Business with Real Estate

    112 W Kelley St, De Soto, MO 63020

    Operating used tire business with real estate in De Soto.

    • Established used tire business with real estate included, offering immediate business opportunity.
    • Commercial building featuring a customer area, office, bathroom, and convenient 4‑bay lean‑to.
    • Includes business equipment, inventory, and tire stock (quantity subject to change).
    • Potential for continued business growth and real estate value appreciation.
    • 1920 two‑story house with rehab potential for rental income or business use.
    Updated: Mar 5
    View details
    Historic Mixed-Use Commercial Property
    $219,000
    4,095 SF

    Historic Mixed-Use Commercial Property

    400 N 3Rd St, De Soto, MO 63020

    Unique 4,095 SF commercial property in downtown De Soto.

    • Prime downtown De Soto location on a corner lot.
    • Unique historical property: Originally an 1866 schoolhouse/church with American Vernacular architecture.
    • Spacious 4,095 sq ft layout including a large fellowship hall, kitchen, and two additional rooms.
    • Mixture of significant updates and restoration to preserve historical quality.
    • Stunning architectural details: stained‑glass windows and original ornate lighting.
    Updated: Feb 17
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    Highway 21 Commercial Opportunity
    $419,000
    4.05 Acres

    Highway 21 Commercial Opportunity

    7,788 sq. ft. building on 4 acres in De Soto.

    13326 Rte 21, De Soto, MO 63020
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    De Soto Retail Business Opportunity
    $850,000
    15,500 SF

    De Soto Retail Business Opportunity

    Own a business and a piece of history!

    400 S Main St, De Soto, MO 63020
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    Spacious Ranch with Modern Comforts
    $950,000
    2,698 SF

    Spacious Ranch with Modern Comforts

    Custom-built home on 33 acres, ideal for country living.

    3700 State Road V, De Soto, MO 63020
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    De Soto Farm with Highway Frontage
    $699,900
    67.94 Acres

    De Soto Farm with Highway Frontage

    68-acre farm near De Soto with highway and county road frontage.

    State Route 21, De Soto, MO 63020
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    De Soto Church Building on 5+ Acres
    $399,900
    3,739 SF

    De Soto Church Building on 5+ Acres

    Church building with spacious sanctuary and high-visibility location.

    4041 Maple Downs Ct, De Soto, MO 63020
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    Remodeled Mixed-Use Property in De Soto
    Pending
    $164,000
    0.16 Acres

    Remodeled Mixed-Use Property in De Soto

    Remodeled 2-bedroom home with commercial zoning in De Soto, MO.

    401 E Miller St, De Soto, MO 63020
    View details
    68 Acres Near Highway Frontage
    $699,900
    67.94 Acres

    68 Acres Near Highway Frontage

    68 acre property near school, shopping, and highway frontage.

    State Route 21, De Soto, MO 63020
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    De Soto Farm Land
    Pending
    $116,000
    46.00 Acres

    De Soto Farm Land

    46+/- acre farm property in De Soto, Missouri.

    3361 State Road V, De Soto, MO 63087
    View details
    Engledow Timber & Pasture Ranch
    $749,900
    110.00 Acres

    Engledow Timber & Pasture Ranch

    110-Acre Missouri Farm, Hunting, & Recreation

    5225 Engledow Rd, De Soto, MO 63020
    View details
    Based on your search, we've compiled 15 Potential Opportunities for your consideration. Besides 11 Active listings in De Soto, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    10-Acre Lot for Custom Home
    Pending
    $140,280
    10.02 Acres

    10-Acre Lot for Custom Home

    Flat, level 10-acre lot ideal for farming and livestock.

    2 Lot Hematite Farms Rd, Festus, MO 63028
    View details
    Land Ideal for Hobby Farm
    Pending
    $140,280
    10.02 Acres

    Land Ideal for Hobby Farm

    10.02-acre lot perfect for horses or hobby farm.

    3 Lot Hematite Farms Rd, Festus, MO 63028
    View details
    Auto Mechanic Shop For Sale
    $145,000
    1,800 SF

    Auto Mechanic Shop For Sale

    Auto mechanic building and shop with three drive-in bay doors.

    10045 Silver Springs Rd, Bonne Terre, MO 63628
    View details
    Bonne Terre Retail Opportunity
    $850,000
    8,200 SF

    Bonne Terre Retail Opportunity

    8,200 SF retail space for sale or lease.

    7 Northwood Dr, Bonne Terre, MO 63628
    View details

    De Soto, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 11 commercial real estate for sale in De Soto, MO, showcased through 11 active listings on our real estate platform. These investment opportunities span a total of 14,623,855 square feet of properties for sale, with an estimated market value of $5,382,600.

    Sale prices for business properties in De Soto, MO start at $115,000, averaging $489,327, and reaching up to $950,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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