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    Frederick County, MD Commercial Real Estate for Sale

    102 results
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    Frederick Office Suite For Sale
    $419,999

    Frederick Office Suite For Sale

    6550 MERCANTILE Drive E unit: 105, Frederick, MD 21703

    Street-level office suite with tax benefits and modern design.

    • Significantly lower tax burden due to location outside Frederick City limits.
    • Strategic location in Frederick County with easy access to I‑270, I‑70, and Route 15.
    • Functional 1,520 sq ft layout with reception area, private offices, and flexible open space.
    • Suitable for professional or medical use with ADA‑compliant accessibility.
    • Abundance of natural light creating a comfortable environment.
    Updated: Mar 2
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    Frederick Medical/Office Condo For Sale
    $624,999

    Frederick Medical/Office Condo For Sale

    100 TUSCANNY #5, Frederick, MD 21702

    Professional medical/office condo in Frederick, ideal for owner-occupants or investors.

    • Prime location in the heart of Frederick, offering strong visibility and convenient access to major commuter routes, downtown, and Frederick Health facilities.
    • Functional layout designed for medical/professional use, including multiple exam/office rooms, reception/waiting area, and private workspaces.
    • Huge basement with high ceilings, two rear exits, and a utility sink, providing extensive storage and expansion potential.
    • Two bathrooms: one full bath with a shower and one half bath.
    • Well‑maintained suite in an established medical/professional complex with ample parking and a well‑managed association.
    Updated: Jan 2
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    Downtown Frederick Office/Medical Space
    $643,500

    Downtown Frederick Office/Medical Space

    974 SF office/medical space in historic downtown Frederick.

    241 E 4TH Street unit: 204A, Frederick, MD 21701
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    Frederick Office/Medical Building For Sale
    $3,250,000
    1.03 Acres

    Frederick Office/Medical Building For Sale

    10,600 SF office/medical building with onsite parking and natural light.

    195 THOMAS JOHNSON Drive, Frederick, MD 21702
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    Emmitsburg Commercial Property For Sale
    $650,000
    0.49 Acres

    Emmitsburg Commercial Property For Sale

    High-visibility commercial real estate with a nationally recognized tenant.

    210 SETON Avenue, Emmitsburg, MD 21727
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    Emmitsburg Farm with Two Homes
    $1,100,000
    108.96 Acres

    Emmitsburg Farm with Two Homes

    108-acre farm featuring two homes and multiple outbuildings.

    TRACT 1: 108+/- ACRES AT 16751 SCOTT Road, Emmitsburg, MD 21727
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    Historic Farm with Modern Amenities
    $1,500,000
    37.20 Acres

    Historic Farm with Modern Amenities

    37-acre Middletown farm featuring historic charm and modern updates.

    2730 MARKER RD, Middletown, MD 21769
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    Downtown Frederick Office/Medical Space
    $789,900

    Downtown Frederick Office/Medical Space

    2,848 SF office/medical space in historic downtown Frederick.

    241 E 4TH Street unit: 105, Frederick, MD 21701
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    Renovated Building Near Green Hill
    $995,000
    3,000 SF

    Renovated Building Near Green Hill

    Versatile renovated building with ample parking and accessibility features.

    5529 ADAMSTOWN ROAD, Adamstown, MD 21710
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    Land in Frederick, Maryland
    $595,000
    4.75 Acres

    Land in Frederick, Maryland

    4.75 acre land parcel suitable for storage or warehouse development.

    WINCHESTER Boulevard, Frederick, MD 21703
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    Industrial Land in Frederick, MD
    $499,000
    2.61 Acres

    Industrial Land in Frederick, MD

    2.61 acre industrial lot with development and income potential.

    4060 STANFORD Court, Frederick, MD 21703
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    Buckeystown Industrial Land For Sale
    $300,000
    2.32 Acres

    Buckeystown Industrial Land For Sale

    2.32 acre industrial lot in Southern Frederick County.

    MICHAELS MILL Road, Buckeystown, MD 21717
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    Downtown Frederick Office Space
    $631,250
    2,525 SF

    Downtown Frederick Office Space

    Unique office space in historic building with modern amenities.

    241 E 4th St #206, Frederick, MD 21701
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    Spacious Farmette on Nearly 4 Acres
    $695,000
    2,668 SF

    Spacious Farmette on Nearly 4 Acres

    Well-maintained farmette with equestrian facilities and recent updates.

    5519 Cindy Ct, Mount Airy, MD 21771
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    Commercial Property with National Tenant
    $650,000
    0.49 Acres

    Commercial Property with National Tenant

    High-visibility commercial real estate with a nationally recognized tenant.

    210 Seton Ave, Emmitsburg, MD 21727
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    Secluded Mountain Retreat Near Frederick
    $649,900
    1,152 SF

    Secluded Mountain Retreat Near Frederick

    Custom square-log home on 7 acres, 20 minutes from Frederick.

    13533 Catoctin Hollow, Thurmont, MD 21788
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    Leased Mixed-Use Frederick Property
    $1,500,000
    0.05 Acres

    Leased Mixed-Use Frederick Property

    Income-producing property in a desirable, walkable downtown location.

    23-25-27 S MARKET ST, Frederick, MD 21701
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    Retail Shop in Woodsboro
    $349,900
    0.28 Acres

    Retail Shop in Woodsboro

    Retail shop or other uses in the heart of Woodsboro.

    200 Main St S, Woodsboro, MD 21798
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    Historic Building with Updated Interior
    $749,000
    0.20 Acres

    Historic Building with Updated Interior

    Updated historic building suitable for a small business owner.

    3504 Urbana Pike, Urbana, MD 21704
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    Historic Downtown Mount Airy Retail
    $2,850,000
    9,613 SF

    Historic Downtown Mount Airy Retail

    Two retail buildings in historic Mount Airy downtown.

    233-239 South Main Street, Mount Airy, MD 21771
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    Freestanding Office/Medical Building For Sale
    $3,250,000
    10,600 SF

    Freestanding Office/Medical Building For Sale

    10,600 SF office/medical building with parking and natural light.

    195 Thomas Johnson Dr, Frederick, MD 21702
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    Mixed-Use Property on Route 27
    $1,750,000
    0.99 Acres

    Mixed-Use Property on Route 27

    Two-parcel commercial property suitable for mixed-use development.

    806 PARK AVENUE, Mount Airy, MD 21771
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    Downtown Frederick Commercial Opportunity
    $545,000
    0.10 Acres

    Downtown Frederick Commercial Opportunity

    Prime commercial property in downtown Frederick with versatile zoning.

    325 W 7th St, Frederick, MD 21701
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    Free Standing Retail Building
    $645,000
    2,730 SF

    Free Standing Retail Building

    Two-story retail building with open floor plan and parking.

    104 W Ridgeville Blvd, Mount Airy, MD
    View details

    Frederick County, MD Commercial Real Estate Investment Opportunities Market Analysis

    Explore 102 commercial real estate for sale in Frederick County, MD, showcased through 102 active listings on our real estate platform. These investment opportunities span a total of 13,916,113 square feet of properties for sale, with an estimated market value of $36,915,090.

    Sale prices for business properties in Frederick County, MD start at $99,990, averaging $1,605,003, and reaching up to $6,900,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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