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    Port St Lucie, FL Commercial Real Estate for Sale

    249 results
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    US-1 Frontage Commercial Lot
    Pending
    $999,888
    0.79 Acres

    US-1 Frontage Commercial Lot

    10720 S Us Highway 1, Port St Lucie, FL 34952

    Commercial lot with high traffic frontage on US-1.

    • 155 Foot Frontage on High‑Traffic US‑1 (Highest Traffic Volume in St. Lucie County)
    • Strategic Location on US‑1 Between Port St. Lucie Blvd and Lennard Road
    • General Commercial Zoning Offers a Wide Variety of Uses
    • Large 34,412 Square Foot Lot (Over 3/4 Acre)
    • Existing Shop with Large Covered Work Area and Additional Storage Sheds
    Updated: Jan 2
    View details
    Medical Office in Excellent Condition
    $499,000
    0.02 Acres

    Medical Office in Excellent Condition

    439 NW Prima Vista Blvd, Port St Lucie, FL 34983

    Well-located medical office with five exam rooms and ample space.

    • Medical office in excellent condition
    • Well located between I‑95 and US Highway One
    • Five exam rooms with sinks
    • Large waiting room
    • Large nurse workstation
    Updated: Nov 4, 2025
    View details
    Port St Lucie Industrial Duplex
    $2,895,000
    0.92 Acres

    Port St Lucie Industrial Duplex

    Fully leased, renovated industrial duplex near major highways.

    1725-1733 SW Biltmore St, Port St Lucie, FL 34984
    View details
    Profitable Jamaican Restaurant Opportunity
    $125,000

    Profitable Jamaican Restaurant Opportunity

    Turn-key Jamaican restaurant for sale in Port St. Lucie.

    3453 SW Darwin Blvd, Port St Lucie, FL 34953
    View details
    Medical Marijuana Business Opportunity
    $165,000
    1,816 SF

    Medical Marijuana Business Opportunity

    Established medical marijuana card clinic with recurring clients for sale.

    Port St Lucie, FL 34953
    View details
    Motorcoach Resort Lot with Tiki
    $244,900

    Motorcoach Resort Lot with Tiki

    Large lot in St. Lucie West resort with Tiki.

    13 NW Boundary Dr, Port St Lucie, FL 34986
    View details
    Established Restaurant Opportunity
    $699,000
    1,400 SF

    Established Restaurant Opportunity

    Profitable Italian restaurant for sale in Rivergate Plaza.

    1125-1193 SE Port St Lucie Blvd, Port St Lucie, FL 34952
    View details
    Medical Office Building For Sale
    $4,700,000

    Medical Office Building For Sale

    Medical office building with flexible space and modern amenities.

    451 SW Bethany Dr, Port St Lucie, FL 34986
    View details
    Prime Location Retail/Gas Station Opportunity
    $1,500,000

    Prime Location Retail/Gas Station Opportunity

    High-visibility property near major retailers, suitable for various commercial uses.

    00 Prima Vista Blvd, Port St Lucie, FL 34952
    View details
    Retail Space in Port St. Lucie
    Contact for pricing

    Retail Space in Port St. Lucie

    Retail space available in a fast-growing Port St. Lucie location.

    7121 S Us Hwy 1 Hwy, Port St Lucie, FL 34950
    View details
    Professional/Medical Office Space For Sale
    $300,000

    Professional/Medical Office Space For Sale

    Office space for sale near HCA Florida St. Lucie Hospital.

    1400 NE Goldtree Dr, Port St Lucie, FL 34952
    View details
    Commercial Laundry Service Business Opportunity
    $1,150,000
    5,250 SF

    Commercial Laundry Service Business Opportunity

    Established laundry service business with equipment, lease, clients, and vehicles.

    679 NW Enterprise Dr, Port St Lucie, FL
    View details
    St. Lucie West Landmark Building
    Contact for pricing
    41,753 SF

    St. Lucie West Landmark Building

    Professional and medical office space in a prominent four-story building.

    1660 Saint Lucie West Blvd, Port St Lucie, FL 34986
    View details
    Freestanding Building in Town Centre
    $750,000
    620 SF

    Freestanding Building in Town Centre

    Renovated building with ample lot space in regional shopping center.

    10425 South Hwy U.S, Port St Lucie, FL 34952
    View details
    Professional Office Space Available
    Contact for pricing

    Professional Office Space Available

    Class A office space with private offices and amenities.

    240 NW Peacock Blvd, Port St Lucie, FL 34986
    View details
    New Retail Center in Tradition
    $8,850,000
    14,175 SF

    New Retail Center in Tradition

    Class A retail center in a rapidly growing area.

    Crosstown Pkwy, Port St Lucie, FL
    View details
    Established Arcade Business For Sale
    $2,200,000
    4,000 SF

    Established Arcade Business For Sale

    Profitable arcade business in a high-traffic location.

    7121-7145 S Us Highway 1, Port St Lucie, FL 34952
    View details
    Luxury RV Resort Lot
    $150,000

    Luxury RV Resort Lot

    Lot in luxury RV resort with many amenities.

    17 NW Boundary Dr, Port St Lucie, FL 34986
    View details
    Port St. Lucie Retail Opportunity
    $3,750,000
    23,756 SF

    Port St. Lucie Retail Opportunity

    Tilt-wall construction retail property in a high-traffic Port St. Lucie location.

    529 NW Prima Vista Blvd, Port St Lucie, FL 34983
    View details
    Executive Office Suite For Sale
    Contact for pricing

    Executive Office Suite For Sale

    Class A office suite in Port St. Lucie medical corridor.

    2100 SE Hillmoor Dr, Port St Lucie, FL 34952
    View details
    Professional Office Suite in St. Lucie
    Contact for pricing

    Professional Office Suite in St. Lucie

    Well-maintained 3,500 SF office suite near Clover Park.

    544 NW University Blvd, Port St Lucie, FL 34986
    View details
    Move-in Ready RV Lot
    $249,000

    Move-in Ready RV Lot

    RV lot in gated community with amenities and outdoor kitchen.

    185 NW Hazard Way, Port St Lucie, FL 34986
    View details
    Leased Warehouse Unit For Sale
    $339,000

    Leased Warehouse Unit For Sale

    1,225 SF leased warehouse unit with double street access.

    1256 SW Biltmore St, Port St Lucie, FL 34953
    View details
    Motorcoach Resort Lot with Tiki
    $225,000

    Motorcoach Resort Lot with Tiki

    Back-in lot with tiki in gated resort community.

    497 NW Boundary Dr, Port St Lucie, FL 34986
    View details

    Port St Lucie, FL Commercial Real Estate Investment Opportunities Market Analysis

    Explore 89 commercial real estate investment opportunities in Port St Lucie, FL with 249 listings featured on our commercial real estate marketplace. The current inventory includes 1,804,490,625 square feet of properties with an estimated value of $49,886,582.

    Estimated prices for commercial real estate in Port St Lucie, FL begin at $55,000, with an average of $311,791 and extend to $2,895,000.

    In Port St Lucie, FL, current investment values show:

    • Land positioned at $275,394
    • Residential land & home lots measuring $286,599
    • Hospitality properties assessed at $243,908
    • Campgrounds calculated at $241,655
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    Browse Commercial real estate for Sale Near Port St Lucie, FL

    Popular Searches in Port St Lucie, FL

    Most Searched ZIP Codes in Port St Lucie, FL

    • 34986
    • 34953
    • 34952
    • 34983
    • 34984
    • 34987
    • 34950

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