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    Florence, CO Commercial Real Estate for Sale

    20 results
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    Historic Downtown Florence Live-Work Space
    $675,000
    0.08 Acres

    Historic Downtown Florence Live-Work Space

    122 W Main St, Florence, CO 81226

    Live-work investment opportunity in historic downtown Florence, Colorado.

    • Live‑work investment opportunity in Historic Downtown Florence.
    • Includes commercial space (previously a wine bar) and a 2‑bedroom residential unit.
    • Prime location on Main Street, close to amenities.
    • Ample free customer parking.
    • Near outdoor recreation: Arkansas River, rafting, hiking, biking, rock climbing.
    Updated: Oct 31, 2025
    View details
    Mixed-Use Building in Florence, CO
    $300,000

    Mixed-Use Building in Florence, CO

    108 W Main St, Florence, CO 81226

    Classic mixed-use building with remodeling potential on Main Street.

    • Mixed‑use building on Main St. in Florence
    • Over 16,000 sq ft of space
    • Potential for apartment or condo units on the second floor
    • Partially remodeled bowling alley
    • Basement with opportunity for speakeasy or pool hall
    Updated: Nov 28, 2025
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    Historic Mixed-Use Building with Loft
    $480,000
    2,850 SF

    Historic Mixed-Use Building with Loft

    Main Street investment opportunity with business spaces and luxury loft.

    119 Main St, Florence, CO 81226
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    Main Street Commercial Opportunity
    $650,000
    15,519 SF

    Main Street Commercial Opportunity

    Mixed-use property with restaurant, retail, apartments, and development potential.

    102-106 Main St, Florence, CO 81226
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    Historic Building in Florence's Golden Block
    $399,400
    0.08 Acres

    Historic Building in Florence's Golden Block

    Turnkey business opportunity in Florence's thriving downtown retail area.

    111 W Main St, Florence, CO 81226
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    Mixed-Use Property on Main Street
    $225,000
    0.47 Acres

    Mixed-Use Property on Main Street

    Versatile property with residential and commercial potential in Florence, CO.

    305 W Main St, Florence, CO 81226
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    Profitable Mini-Storage Investment Opportunity
    $249,900
    4.20 Acres

    Profitable Mini-Storage Investment Opportunity

    Profitable mini-storage facility with expansion potential in Florence, Colorado.

    260 Moore Dr, Florence, CO 81226
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    Main Street Commercial Opportunity
    $650,000
    0.22 Acres

    Main Street Commercial Opportunity

    Mixed-use property with restaurant, retail, and residential potential.

    102-106 E Main St, Florence, CO 81226
    View details
    Historic Downtown Florence Mixed-Use Building
    $480,000
    0.08 Acres

    Historic Downtown Florence Mixed-Use Building

    Mixed-use building with business spaces and luxury loft in Florence.

    119 W Main St, Florence, CO 81226
    View details
    Mixed-Use Investment in Historic Downtown
    $675,000
    0.08 Acres

    Mixed-Use Investment in Historic Downtown

    Live-work investment opportunity in Florence's Historic Downtown on Main Street.

    122 W Main St, Florence, CO 81226
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    Mixed-Use Building in Florence, CO
    $300,000
    0.17 Acres

    Mixed-Use Building in Florence, CO

    Classic mixed-use building with remodeling potential on Main Street.

    108 W Main St, Florence, CO 81226
    View details
    Versatile Commercial Space in Florence
    $300,000

    Versatile Commercial Space in Florence

    5,600 sq ft commercial space with flexible zoning.

    117 S Petroleum Ave, Florence, CO 81226
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    Florence Main Street Mixed-Use Gem
    $350,000
    0.18 Acres

    Florence Main Street Mixed-Use Gem

    Historic building, high potential, 16,000+ sq ft.

    108 Main St, Florence, CO 81226
    View details
    Florence Industrial Property: Prime Location
    $550,000
    16,672 SF

    Florence Industrial Property: Prime Location

    1.64-acre lot, two buildings, rail spur.

    201 Robinson Ave, Florence, CO 81226
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    Prime Florence Main Street Mixed-Use
    $675,000
    15,519 SF

    Prime Florence Main Street Mixed-Use

    High-traffic location, multiple income streams.

    102-106 Main St, Florence, CO 81226
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    119 Main St, Florence, CO 81226
    $495,000
    0.08 Acres

    119 Main St, Florence, CO 81226

    Mixed-use properties • 0.08 Acres

    119 Main St, Florence, CO 81226
    View details
    Prime Florence Mixed-Use Opportunity
    $675,000
    0.22 Acres

    Prime Florence Mixed-Use Opportunity

    Main Street gem: 5 income streams!

    Main St, Florence, CO 81226
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    Florence Commercial Bar & Restaurant
    $329,900
    2,000 SF

    Florence Commercial Bar & Restaurant

    Thriving business, high visibility, turnkey operation.

    114 Main St, Florence, CO 81226
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    Central Florence Office Building
    Contact for pricing
    4,786 SF

    Central Florence Office Building

    Well-maintained office building in central Florence, Colorado.

    521 W 5Th St, Florence, CO 81226
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    Medical Office Building For Sale
    $460,000
    2,800 SF

    Medical Office Building For Sale

    Medical office building with new tenant improvements in central Florence.

    515 W 3Rd St, Florence, CO 81226
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    Based on your search, we've compiled Potential Opportunities for your consideration. Besides 20 Active Listings in Florence, CO, we suggest to view alternatives - similar 144 Off-Market properties to explore as potential leads.

    Explore Off-Market Properties in Florence, CO

    Consider similar Off-Market properties in Florence, CO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    Main St

    Main St

    Mixed-use properties • 0.22 Acres
    Value Estimation by Request
    Main St, Florence, CO 81226
    View details
    728 Crk 119

    728 Crk 119

    Commercial real estate • 3,079 SF
    Value Estimation by Request
    728 Crk 119, Florence, CO 81226
    View details
    122 Main St

    122 Main St

    Retail properties • 5,300 SF
    Value Estimation by Request
    122 Main St, Florence, CO 81226
    View details
    119 Main St

    119 Main St

    Mixed-use properties • 0.08 Acres
    Value Estimation by Request
    119 Main St, Florence, CO 81226
    View details

    Florence, CO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 132 commercial real estate investment opportunities in Florence, CO with 20 listings featured on our commercial real estate marketplace. The current inventory includes 29,624,886 square feet of properties with an estimated value of $46,359,998.

    Estimated prices for commercial real estate in Florence, CO begin at $34,000, with an average of $445,769 and extend to $2,635,000.

    In Florence, CO, current investment values show:

    • Retail properties positioned at $477,145
    • Individual retail properties measuring $467,058
    • Land assessed at $284,568
    • Retail space calculated at $348,823
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    • 81226

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