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    Wise County, VA Commercial Real Estate for Lease

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    Richmond, VA Virginia Beach, VA Alexandria, VA
    10 results
    Commercial Property in Big Stone Gap
    $350,000 SF/Yr
    1,400 SF

    Commercial Property in Big Stone Gap

    1809 E 2nd Avenue, Big Stone Gap, VA 24219

    Prominent corner lot suitable for retail or light industrial use.

    • Prominent corner location visible to traffic entering town from US 19.
    • Nearly an acre of fenced land suitable for various uses.
    • Potential for re‑use as convenience retail or light industrial.
    • Existing buildings have utility for service and repair businesses.
    • Office building can be renovated for retail display.
    Updated: Dec 29, 2025
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    Restaurant Opportunity in Big Stone Gap
    $400,000 SF/Yr
    2,359 SF

    Restaurant Opportunity in Big Stone Gap

    516 E 5th St N, Big Stone Gap, VA 24219

    Former Dairy Queen location with drive-thru in downtown Big Stone Gap.

    • Ideal location for a restaurant, formerly a Dairy Queen.
    • High‑visibility downtown location with road frontage.
    • Ready‑to‑go building suitable for immediate occupancy.
    • Ample parking on both sides of the building.
    • Includes a designated drive‑thru area.
    Updated: Oct 13, 2025
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    Outparcel for Lease or Sale
    $25,000 SF/Yr

    Outparcel for Lease or Sale

    0.50 acre outparcel available for lease or sale.

    16427 Wise Street, Saint Paul, VA 24283
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    Retail Space in Stonewall Square
    Contact for pricing
    3,200 SF

    Retail Space in Stonewall Square

    Retail space available in Lexington, Virginia's Stonewall Square shopping mall.

    121-181 Plaza Rd SW, Wise, VA
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    Big Stone Gap Retail Center
    Contact for pricing
    18,764 SF

    Big Stone Gap Retail Center

    Retail and office spaces available in Big Stone Gap, Virginia.

    1937-1957 Neeley Rd, Big Stone Gap, VA
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    Retail Spaces Available on Main
    $7 SF/Yr
    4,400 SF

    Retail Spaces Available on Main

    Two retail spaces available for lease on Main Street.

    730 W Main St, Appalachia, VA
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    Commercial Space in Coeburn, VA
    $3,500/Mo
    8,297 SF

    Commercial Space in Coeburn, VA

    Large commercial space with warehouse storage in Coeburn, Virginia.

    213 E Front Street, Coeburn, VA 24230
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    Historic Retail Space in Coeburn
    $3,500/Mo

    Historic Retail Space in Coeburn

    Unique retail space with historical significance in Coeburn, Virginia.

    417 E Front Street, Coeburn, VA 24230
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    Retail and Office Space Available
    Contact for pricing
    32,236 SF

    Retail and Office Space Available

    Retail and office opportunities in growing Wise, Virginia.

    181 Plaza Rd SW, Wise, VA 24293
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    Powell Valley Shopping Center Space
    Contact for pricing
    20,000 SF

    Powell Valley Shopping Center Space

    Retail and office spaces available in Big Stone Gap, Virginia.

    1941 Neeley Rd, Big Stone Gap, VA 24219
    View details
    Based on your search, we've compiled 41 Potential Opportunities for your consideration. Besides 10 Active listings in Wise County, VA, we suggest exploring alternatives. Similar 31 Properties for Sales.

    Explore Similar Spaces for Sale in Wise County, VA

    Consider Similar Space for Sale. We found 31 Spaces matching your search parameters.

    Car Wash Investment Opportunity
    $775,000
    3,822 SF

    Car Wash Investment Opportunity

    Car wash with income potential in Wise, Virginia.

    123 WOODLAND DR, Wise, VA 24293
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    Commercial Land in Opportunity Zone
    $325,000
    1.07 Acres

    Commercial Land in Opportunity Zone

    Prime commercial land in Wise, VA, with development potential.

    SW Woodland Drive, Wise, VA 24293
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    Mixed-Use Property in Wise, VA
    $325,000
    4,482 SF

    Mixed-Use Property in Wise, VA

    Retail space and apartments in the heart of Wise, Virginia.

    528 W Main Street, Wise, VA 24293
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    Coeburn Multifamily Investment Opportunity
    $1,000,000
    10,000 SF

    Coeburn Multifamily Investment Opportunity

    Four properties with immediate income and significant upside potential.

    207 NE Diagonal Avenue, Coeburn, VA 24230
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    Award-Winning Restaurant with Rental Income
    $229,000
    4,000 SF

    Award-Winning Restaurant with Rental Income

    Turn-key restaurant with rental income in historic Appalachia, Virginia.

    516 W Main Street, Appalachia, VA 24216
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    Wise, VA Opportunity Zone Land
    $325,000

    Wise, VA Opportunity Zone Land

    Land in Wise's retail corridor, ideal for retail/flex development.

    SW Woodland Drive, Wise, VA 24293
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    Mixed-Use Property in Wise, Virginia
    $325,000
    2,462 SF

    Mixed-Use Property in Wise, Virginia

    Commercial space with apartments in the heart of Wise.

    528 W Main Street, Wise, VA 24293
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    Turnkey Commercial Space in Coeburn
    $275,000
    3,600 SF

    Turnkey Commercial Space in Coeburn

    Versatile 3,600 sqft commercial space suitable for various businesses.

    118 NE Grand Avenue, Coeburn, VA 24230
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    Refreshed Commercial Building in St. Paul
    $59,900
    1,000 SF

    Refreshed Commercial Building in St. Paul

    Newly refreshed commercial building in the heart of St. Paul.

    16557 Broad Street, Saint Paul, VA 24283
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    Private Mountain Land for Outdoor Enthusiasts
    $110,000
    78.96 Acres

    Private Mountain Land for Outdoor Enthusiasts

    78.96 acres of private mountain land in Coeburn, VA.

    Bull Run Road, Coeburn, VA 24230
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    Appalachia, VA Commercial Property
    $90,000
    2,874 SF

    Appalachia, VA Commercial Property

    One-story country church with potential for residential or commercial use.

    817 Oakdale Street, Appalachia, VA 24216
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    Versatile Commercial Building, Big Stone Gap
    $269,900
    6,768 SF

    Versatile Commercial Building, Big Stone Gap

    Spacious commercial building in Big Stone Gap with endless potential.

    510 E Wood Avenue, Big Stone Gap, VA 24219
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    Commercial Property in Downtown Wise
    $475,000
    8,900 SF

    Commercial Property in Downtown Wise

    2.088 acres with retail space and development potential.

    119 NW Independence Avenue, Wise, VA 24293
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    Mixed-Use Property in Appalachia, VA
    $115,000
    7,164 SF

    Mixed-Use Property in Appalachia, VA

    Commercial and residential spaces with rental income potential in Appalachia.

    106 Kentucky Avenue unit: A, Appalachia, VA 24216
    View details

    Wise County, VA Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Wise County, VA with 10 listings featured on our commercial real estate exchange. The current inventory includes 18,056 square feet of properties with an estimated lease value of $1,010,122.

    Estimated lease rates for Commercial real estate in Wise County, VA begin at $5 SF/Yr, with an average of $168,353 and extend to $400,000.
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    Browse Commercial real estate for Lease Near Wise, VA

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