Wise County, VA Commercial real estate for Rent & Lease

$249,000 SF/Yr

1,858 SF

Retail Storefront with Drive-Through

102 E 5th Street, Big Stone Gap, VA 24219

Downtown corner storefront with a drive-through window, brand-new roof and HVAC, plus walk-in coolers.

Corner location on Shawnee Ave and 5th St in downtown Big Stone Gap
Drive‑through window for customer service access
Brand new roof, plus new HVAC and heat pump heating and cooling
Super cold walk‑in coolers included for food storage needs
Large exterior raised programmable LED sign on the building

Updated: Jun 8

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$350,000 SF/Yr

1,400 SF

Commercial Property in Big Stone Gap

1809 E 2nd Avenue, Big Stone Gap, VA 24219

Prominent corner lot suitable for retail or light industrial use.

Prominent corner location visible to traffic entering town from US 19.
Nearly an acre of fenced land suitable for various uses.
Potential for re‑use as convenience retail or light industrial.
Existing buildings have utility for service and repair businesses.
Office building can be renovated for retail display.

Updated: Dec 29, 2025

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$400,000 SF/Yr

2,359 SF

Restaurant Opportunity in Big Stone Gap

Former Dairy Queen location with drive-thru in downtown Big Stone Gap.

516 E 5th St N, Big Stone Gap, VA 24219

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$25,000 SF/Yr

Outparcel for Lease or Sale

0.50 acre outparcel available for lease or sale.

16427 Wise Street, Saint Paul, VA 24283

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18,764 SF

Big Stone Gap Retail Center

Retail and office spaces available in Big Stone Gap, Virginia.

1937-1957 Neeley Rd, Big Stone Gap, VA

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3,200 SF

Retail Space in Stonewall Square

Retail space available in Lexington, Virginia's Stonewall Square shopping mall.

121-181 Plaza Rd SW, Wise, VA

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11,608 SF

Retail Space in Ridgeview Centre

Retail space available in a busy Wise, Virginia shopping center.

129 Ridge Circle, Wise, VA 24293

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$3,500/Mo

8,297 SF

Retail Warehouse Rental Space

A large open main room with extensive warehouse storage suited for flexible retail or indoor recreation concepts.

213 E Front Street, Coeburn, VA 24230

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$7 SF/Yr

4,400 SF

Retail Spaces Available on Main

Two retail spaces available for lease on Main Street.

730 W Main St, Appalachia, VA

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$3,500/Mo

Historic Retail Space in Coeburn

Unique retail space with historical significance in Coeburn, Virginia.

417 E Front Street, Coeburn, VA 24230

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20,000 SF

Powell Valley Shopping Center Space

Retail and office spaces available in Big Stone Gap, Virginia.

1941 Neeley Rd, Big Stone Gap, VA 24219

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Based on your search, we've compiled 44 Potential Opportunities for your consideration. Besides 11 Active listings in Wise County, VA, we suggest exploring alternatives. Similar 33 Properties for Sales.

Similar Spaces for Sale in Wise County, VA

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$764,500

3,822 SF

Car Wash Investment Opportunity

Car wash with income potential in Wise, Virginia.

123 WOODLAND DR, Wise, VA 24293

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$188,000

1,344 SF

Commercial Property in Wise, Virginia

Versatile commercial property on approximately 1 acre in Wise, Virginia.

118 Washington Road, Wise, VA 24293

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Award-Winning Restaurant with Rental Income

$229,000

4,000 SF

Award-Winning Restaurant with Rental Income

Turn-key restaurant with rental income in historic Appalachia, Virginia.

516 W Main Street, Appalachia, VA 24216

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$150,000

2,240 SF

Mixed-Use Store and Apartment

A downstairs small store or restaurant space with a separate 2-bed, 1-bath apartment upstairs in a Gen Commercial zone.

1225 Dante Road, Saint Paul, VA 24283

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$325,000

4,482 SF

Mixed-Use Property in Wise, VA

Retail space and apartments in the heart of Wise, Virginia.

528 W Main Street, Wise, VA 24293

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$325,000

2,462 SF

Mixed-Use Property in Wise, Virginia

Commercial space with apartments in the heart of Wise.

528 W Main Street, Wise, VA 24293

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$325,000

1.07 Acres

Commercial Land in Opportunity Zone

Prime commercial land in Wise, VA, with development potential.

SW Woodland Drive, Wise, VA 24293

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$179,000

21.22 Acres

Corner Development Land with Utilities

Level, partially cleared acreage with over 1,000 feet of road frontage and public water and sewer available.

Hurricane Road, Wise, VA 24293

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$325,000

Wise, VA Opportunity Zone Land

Land in Wise's retail corridor, ideal for retail/flex development.

SW Woodland Drive, Wise, VA 24293

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$149,000

0.20 Acres

Mixed-Use Investment Opportunity

Cash-flowing property with commercial space and apartments near amenities.

201 S 5th Street, Big Stone Gap, VA 24219

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$115,000

7,164 SF

Mixed-Use Property in Appalachia, VA

Commercial and residential spaces with rental income potential in Appalachia.

106 Kentucky Avenue, Appalachia, VA 24216

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$199,000

960 SF

Turnkey Restaurant in Prime Location

Profitable, fully equipped restaurant in high-traffic area, ready for new owner.

314 E Front Street, Coeburn, VA 24230

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Refreshed Commercial Building in St. Paul

$59,900

1,000 SF

Refreshed Commercial Building in St. Paul

Newly refreshed commercial building in the heart of St. Paul.

16557 Broad Street, Saint Paul, VA 24283

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