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    Wise County, VA Commercial Real Estate for Sale

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    Richmond, VA Fredericksburg, VA Roanoke, VA
    31 results
    Mixed-Use Property in Wise, Virginia
    $350,000
    4,482 SF

    Mixed-Use Property in Wise, Virginia

    528 W Main Street, Wise, VA 24293

    Retail space with apartments in the heart of Wise.

    • Established business location with approximately 2000 sq ft of retail/storage space and income potential from day one.
    • Two occupied apartments generate approximately $2500/month in rental income.
    • Prime location in the heart of Wise, VA, with abundant traffic and convenient access to amenities.
    • Potential to add a studio apartment with a private entrance for additional income.
    • Large storefront windows ideal for retail displays.
    Updated: Jan 29
    View details
    Car Wash Investment Opportunity
    $775,000
    3,822 SF

    Car Wash Investment Opportunity

    123 WOODLAND DR, Wise, VA 24293

    Car wash with income potential in Wise, Virginia.

    • High Traffic Location on Woodland Drive near Norton Rd & Orby Cantrell Hwy, with 26,937 combined traffic count.
    • Strong Income Potential: Gross income exceeds $160,000 per year.
    • Existing Membership Base: 210 annual digital memberships already in place.
    • Multiple Wash Options, featuring 5 self‑serve bays and 1 automatic wash bay.
    • On‑site coin changer for customer convenience.
    Updated: Mar 4
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    Commercial Land in Opportunity Zone
    $325,000
    1.07 Acres

    Commercial Land in Opportunity Zone

    Prime commercial land in Wise, VA, with development potential.

    SW Woodland Drive, Wise, VA 24293
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    Coeburn Multifamily Investment Opportunity
    $1,000,000
    10,000 SF

    Coeburn Multifamily Investment Opportunity

    Four properties with immediate income and significant upside potential.

    207 NE Diagonal Avenue, Coeburn, VA 24230
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    Award-Winning Restaurant with Rental Income
    $229,000
    4,000 SF

    Award-Winning Restaurant with Rental Income

    Turn-key restaurant with rental income in historic Appalachia, Virginia.

    516 W Main Street, Appalachia, VA 24216
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    Wise, VA Opportunity Zone Land
    $325,000

    Wise, VA Opportunity Zone Land

    Land in Wise's retail corridor, ideal for retail/flex development.

    SW Woodland Drive, Wise, VA 24293
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    Mixed-Use Property in Wise, Virginia
    $350,000
    2,462 SF

    Mixed-Use Property in Wise, Virginia

    Commercial space with apartments in the heart of Wise.

    528 W Main Street, Wise, VA 24293
    View details
    Turnkey Commercial Space in Coeburn
    $275,000
    3,600 SF

    Turnkey Commercial Space in Coeburn

    Versatile 3,600 sqft commercial space suitable for various businesses.

    118 NE Grand Avenue, Coeburn, VA 24230
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    Refreshed Commercial Building in St. Paul
    $59,900
    1,000 SF

    Refreshed Commercial Building in St. Paul

    Newly refreshed commercial building in the heart of St. Paul.

    16557 Broad Street, Saint Paul, VA 24283
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    Private Mountain Land for Outdoor Enthusiasts
    $110,000
    78.96 Acres

    Private Mountain Land for Outdoor Enthusiasts

    78.96 acres of private mountain land in Coeburn, VA.

    Bull Run Road, Coeburn, VA 24230
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    Appalachia, VA Commercial Property
    $90,000
    2,874 SF

    Appalachia, VA Commercial Property

    One-story country church with potential for residential or commercial use.

    817 Oakdale Street, Appalachia, VA 24216
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    Versatile Commercial Building, Big Stone Gap
    $269,900
    6,768 SF

    Versatile Commercial Building, Big Stone Gap

    Spacious commercial building in Big Stone Gap with endless potential.

    510 E Wood Avenue, Big Stone Gap, VA 24219
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    Commercial Property in Downtown Wise
    $475,000
    8,900 SF

    Commercial Property in Downtown Wise

    2.088 acres with retail space and development potential.

    119 NW Independence Avenue, Wise, VA 24293
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    Mixed-Use Property in Appalachia, VA
    $115,000
    7,164 SF

    Mixed-Use Property in Appalachia, VA

    Commercial and residential spaces with rental income potential in Appalachia.

    106 Kentucky Avenue unit: A, Appalachia, VA 24216
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    26 Acres in Coeburn, VA
    $265,000
    26.06 Acres

    26 Acres in Coeburn, VA

    26-acre parcel with development potential in Coeburn, Virginia.

    11210 Riverview Road, Coeburn, VA 24230
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    Turnkey Restaurant in Prime Location
    $199,000
    960 SF

    Turnkey Restaurant in Prime Location

    Well-equipped restaurant for sale in high-traffic area.

    314 E Front Street, Coeburn, VA 24230
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    Coeburn Commercial Unit For Sale
    $35,500
    675 SF

    Coeburn Commercial Unit For Sale

    675 SF commercial unit in Coeburn Business Building.

    340 E Front Street, Coeburn, VA 24230
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    Coeburn Business Building Commercial Unit
    $40,500
    675 SF

    Coeburn Business Building Commercial Unit

    675 sq ft commercial unit in Coeburn, Virginia.

    340 Front Street, Coeburn, VA 24230
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    Land in Pound, Virginia
    $40,000
    178,596 SF

    Land in Pound, Virginia

    Approximately 4 acres of land suitable for retail business.

    10007 Orby Cantrell Highway, Unit 6566, Pound, VA 24279
    View details
    Established Animal Hospital For Sale
    $450,000
    2,752 SF

    Established Animal Hospital For Sale

    Veterinary practice in business for 39 years, building only.

    404 NE Hurricane Road, Wise, VA 24293
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    Family Dollar Leased Investment Property
    $1,491,750
    8,400 SF

    Family Dollar Leased Investment Property

    NNN leased investment property with long-term tenant.

    202 FRONT ST, Coeburn, VA 24230
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    Turnkey Restaurant in Prime Location
    $199,000
    0.09 Acres

    Turnkey Restaurant in Prime Location

    Profitable, fully equipped restaurant with loyal customer base and exterior seating.

    314 E Front Street, Coeburn, VA 24230
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    Big Stone Gap Corner Property
    $350,000
    9,400 SF

    Big Stone Gap Corner Property

    Prominent corner location suitable for retail or light industrial.

    1809 2nd Ave E, Big Stone Gap, VA
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    Coeburn Historic Mixed-Use Gem
    $485,000

    Coeburn Historic Mixed-Use Gem

    Three-story building with commercial and residential spaces in historic downtown.

    501 Front Street, Coeburn, VA 24230
    View details

    Wise County, VA Commercial Real Estate Investment Opportunities Market Analysis

    Explore 31 commercial real estate for sale in Wise County, VA, showcased through 31 active listings on our real estate platform. These investment opportunities span a total of 7,194,370 square feet of properties for sale, with an estimated market value of $6,830,050.

    Sale prices for business properties in Wise County, VA start at $35,500, averaging $359,476, and reaching up to $1,491,750 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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