Wythe County, VA Commercial real estate for Rent & Lease

Updated: Jun 18

Downtown Office Suite

285 S 6th Street Suite A, Wytheville, VA 24382

$2,900/Mo

3,000 sqft

3,000 square feet of office space
Multiple private offices plus a large conference room
Waiting area, kitchenette, and 2 bathrooms
Across from the Wythe Co. Court house in downtown Wytheville
Central air and heat pump heating

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Updated: Apr 7

Corner Storefront Space

200 E Monroe St, Wytheville, VA 24382

$2,550/Mo

2,400 sqft

2,400 SF corner storefront at 200 E Monroe St, Wytheville, VA
Located at E Monroe St and N 1st St
Classic brick building with high‑impact window display areas
Signage potential along a prominent corner position
Flexible layout described for office, retail, hospitality, studio, or restaurant use

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Professional Office Suite with Conference Room

285 S 6th Street Suite A, Wytheville, VA 24382

$2,900/Mo

3,000 sqft

Office suite with multiple private offices, a large conference room, waiting area, and kitchenette.

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Renovated Shopping Center Anchored by Big Lots

800 E Main St, Wytheville, VA 24382

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3,081 sqft 8.69 AC lot

Renovated retail shopping center anchored by Big Lots at a high-traffic crossroads with 9,718 VPD reported.

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Shopping Center Anchored by Food Lion

1370-1380 E Main St, Wytheville, VA 24382

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18,900 sqft

Lehy Plaza is anchored by Food Lion and Tractor Supply and sits just off Interstate 81 in Wytheville.

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Retail Space Near Interstate 81

1380 E Main St, Wytheville, VA 24382

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Retail space in shopping center anchored by Food Lion.

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Retail Space in High-Traffic Center

198 Commonwealth Dr, Wytheville, VA 24382

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End unit retail space in Starbucks-anchored center with high foot traffic.

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Renovated Shopping Center For Lease

800 E Main St, Wytheville, VA 24382

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1,065 sqft 8.69 AC lot

Renovated shopping center totaling 99,745 SF on 8.69 acres with 9718 VPD at the I-77 and I-81 crossroads.

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Renovated Retail Shopping Center

800 E Main St, Wytheville, VA 24382

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1,434 sqft 8.69 AC lot

Renovated shopping center offers 99,745 SF on 18.69 acres at a major interstate crossroads.

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Renovated Shopping Center

800 E Main St, Wytheville, VA 24382

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1,040 sqft 8.69 AC lot

Renovated shopping center on 8.69 acres with 9718 VPD exposure at the crossroads of Interstates 77 and 81.

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Based on your search, we've compiled 72 Potential Opportunities for your consideration. Besides 10 Active listings in Wythe County, VA, we suggest exploring alternatives. Similar 62 Properties for Sales.

Similar Spaces for Sale in Wythe County, VA

Consider Similar Space for Sale. We found 62 Spaces matching your search parameters.

Mixed-Use Building with Elevator

1340 W Main St, Wytheville, VA 24382

$600,000

14,519 sqft

M-1 zoning, brick construction, and public utilities support a versatile commercial layout.

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Mixed-Use Building with Open Layout

1340 W Main St, Wytheville, VA 24382

$600,000

14,519 sqft

Mixed-use building offering office and storefront space with an open floor plan and potential upstairs apartment conversion.

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Two-Story Mixed-Use Building

195 S 1st Street, Wytheville, VA 24382

$399,000

4,949 sqft

Downtown corner property with occupied main-level spaces and additional commercial area on the second floor.

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Grocery-Anchored Shopping Center

1380 E Main St, Wytheville, VA 24382

$8,060,550

87,964 sqft 9.20 AC lot

Grocery-anchored shopping center offering 87,964 square feet on 9.196 acres at the I-81/I-77 intersection.

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Two-Building Religious Facility

146 Cammellia Lane, Speedwell, VA 24374

$150,000

3,200 sqft

Rel-Comm zoning, public water, and septic service support the property’s existing commercial configuration.

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Single-Level Office Property

134 Needmore St, Wytheville, VA 24382

$249,500

2,422 sqft 0.70 AC lot

Brick office property with dual-street access, public water and sewer, and a flexible interior layout.

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Owner-Occupant Office with Parking

170 S 16th St, Wytheville, VA 24382

$170,000

1,080 sqft

Office property in Wytheville with its own parking lot and storage building, suited for owner-occupants or investors.

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Mixed-Use Property with Warehouse/Office

7907 W Lee Hwy, Rural Retreat, VA 24368

$165,000

3,860 sqft

Includes a two-bedroom single wide and a metal warehouse/office area configured for residential use.

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Mixed-Use Building with Apartment

515 E Main St, Wytheville, VA 24382

$60,000

2,340 sqft

Two-level property combining former retail space with an upstairs apartment in a B-2DT zoning district.

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Dollar General NNN Retail Property

6840 W Lee Hwy, Rural Retreat, VA 24368

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9,100 sqft 1.00 AC lot

Corporate-backed retail investment with an absolute NNN lease and limited landlord obligations.

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Grocery-Anchored Retail Center

1370-1380 E Main St, Wytheville, VA 24382

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87,964 sqft

100% occupied grocery-anchored center with contractual rent growth and national credit tenants across grocery, pharmacy, and lifestyle retail.

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Retail Property at Interstate Convergence

145 Commonwealth Drive, Wytheville, VA 24382

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4,696 sqft

Retail building positioned at the I-77 and I-81 convergence with visibility to more than 30,000 vehicles daily.

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Corner Commercial Land Parcel

Fort Chiswell Road, Austinville, VA 24312

$275,000

3.83 AC lot

C1-zoned commercial land with public water and sewer access near major regional routes.

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Commercial Land with Existing Structure

1160 W Lee Highway, Wytheville, VA 24382

$169,000

12.50 AC lot

B2-zoned commercial tract in town with water available and an older structure on site.

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