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    Onondaga County, NY Commercial Real Estate for Lease

    192 results
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    East Syracuse Commercial Space Available
    $1,900 /Mo
    14,506 SF

    East Syracuse Commercial Space Available

    5710 Commons Park, East Syracuse, NY 13057

    Class A office space in desirable East Syracuse location.

    • Highly desirable location near Widewaters Parkway with easy access to major highways and downtown Syracuse.
    • Gross lease: Landlord pays for heat, air conditioning, and electricity.
    • Impeccably maintained Class A professional building with newly remodeled kitchen and recently painted exterior.
    • Excellent accessibility: One‑story building with no stairs and plenty of free parking.
    • Access to shared restrooms, conference room, and outdoor patio.
    Updated: Dec 30, 2025
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    Brewerton Commercial Building For Rent
    $4,600 /Mo
    4,416 SF

    Brewerton Commercial Building For Rent

    9168 Brewerton Road, Brewerton, NY 13029

    4400+ sq ft building in prime Cicero location.

    • Prime location in the heart of Cicero, close to Micron, 81 Freeway, and restaurants.
    • Large lot size: Over 1 acre of land.
    • Substantial building size: Over 4400 sq. ft.
    • Updated office/reception area with two bathrooms.
    • Individually zoned heating and cooling.
    Updated: Feb 3
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    Syracuse Retail Space For Rent
    $2,434 /Mo
    3,650 SF

    Syracuse Retail Space For Rent

    Large retail space on a busy corner, ready for your business.

    910 Park Street, Syracuse, NY 13208
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    Syracuse Office Space Sublease
    $5,000 /Mo
    37,112 SF

    Syracuse Office Space Sublease

    Office space for sublease, all-inclusive rent covers utilities and maintenance.

    422 W Onondaga Street, Syracuse, NY 13202
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    Downtown Syracuse Office Space Available
    $10,000 /Mo
    39,245 SF

    Downtown Syracuse Office Space Available

    Prime downtown Syracuse office space with parking available for lease.

    344 W Genesee Street, Syracuse, NY 13202
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    Retail Space on Busy Street
    $1,200 /Mo
    500 SF

    Retail Space on Busy Street

    Renovated retail space suitable for various business models.

    1211 Milton Avenue, Syracuse, NY 13204
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    Renovated Warehouse with Flexible Space
    $4,900 /Mo
    6,528 SF

    Renovated Warehouse with Flexible Space

    Stand-alone, renovated warehouse with potential for two separate units.

    6263 E Taft Road, Syracuse, NY 13212
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    Freestanding Retail Property on Brewerton Road
    $13 SF/Yr
    10,908 SF

    Freestanding Retail Property on Brewerton Road

    10,908 SF retail space with drive-thru and ample parking.

    2616 Brewerton Road, Mattydale, NY 13211
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    Medical Office Space Available
    $19 SF/Yr
    5,126 SF

    Medical Office Space Available

    5,126 SF medical office suite for lease.

    792 North Main Street, North Syracuse, NY 13212
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    Turnkey Commercial Space Available
    $14 SF/Yr
    4,890 SF

    Turnkey Commercial Space Available

    Versatile 1,200 sq ft space ideal for retail or office.

    634 Old Liverpool Rd, Liverpool, NY 13088
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    Development Opportunity Near Micron Site
    $2,200,000
    239,580 SF

    Development Opportunity Near Micron Site

    5.5 acre commercial land near Micron development with highway visibility.

    8860 Brewerton Road, Brewerton, NY 13029
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    Pioneer Business Park Office Suite
    $16 SF/Yr
    6,556 SF

    Pioneer Business Park Office Suite

    Build-to-suit office suite in a vibrant business park.

    5009 Campuswood Dr, East Syracuse, NY 13057
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    Creative Office Space in Syracuse
    $16 SF/Yr
    2,500 SF

    Creative Office Space in Syracuse

    Modern office space with natural light and flexible floor plans.

    200 S Geddes St, Syracuse, NY
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    2.11 Acre Commercial Building Lot
    $199,000
    8,000 SF

    2.11 Acre Commercial Building Lot

    Commercial building lot with road frontage near Route 31.

    0000 State Route 31, Clay, NY 13027
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    Redevelopment Opportunity with Warehouse
    $10 SF/Yr
    2,550 SF

    Redevelopment Opportunity with Warehouse

    Land for lease with warehouse and redevelopment potential.

    133 W. Seneca Street, Manlius, NY 13104
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    Prime Retail Space on Genesee
    Contact for pricing

    Prime Retail Space on Genesee

    Highly visible retail space in a busy Syracuse corridor.

    3514 W Genesee St, Syracuse, NY 13219
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    Retail Space in Madison Row
    Contact for pricing
    11,149 SF

    Retail Space in Madison Row

    11,149 SF retail space in a thriving suburban community.

    7660 Highbridge Rd, Manlius, NY 13104
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    East Syracuse Office Building For Rent
    $4,220 /Mo
    5,064 SF

    East Syracuse Office Building For Rent

    5,064 SF office building with yard and generator.

    6331 E Molloy Rd, East Syracuse, NY
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    Former KFC on Oswego Rd
    Contact for pricing

    Former KFC on Oswego Rd

    High-traffic location near Wegmans and Target, ideal for retail.

    7601 Oswego Rd, Liverpool, NY 13090
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    Class A Office Suites Available
    Contact for pricing
    7,092 SF

    Class A Office Suites Available

    Modern office suites with ample natural light near major highways.

    225 Greenfield Parkway, Liverpool, NY 13088
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    Professional Office Space Available
    $16 SF/Yr
    2,029 SF

    Professional Office Space Available

    2,029 SF office space with highway and university access.

    3125 East Genesee Street, Syracuse, NY 13224
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    Iconic Mixed-Use State Tower
    $18 SF/Yr
    23,201 SF

    Iconic Mixed-Use State Tower

    Mixed-use property with office, residential, and retail spaces available.

    109 South Warren Street, Syracuse, NY 13202
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    Syracuse Office Space Available
    $13 SF/Yr
    2,600 SF

    Syracuse Office Space Available

    Office space available for rent in Syracuse, New York.

    208 S Warren St, Syracuse, NY
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    Prime Armory Square Office Space
    $12 SF/Yr
    2,500 SF

    Prime Armory Square Office Space

    Commercial office space for lease in the heart of Armory Square.

    316 S Clinton St, Syracuse, NY
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    Onondaga County, NY Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Onondaga County, NY with 192 listings featured on our commercial real estate exchange. The current inventory includes 11,309,003,640 square feet of properties with an estimated lease value of $319 /Mo.

    Estimated lease rates for Commercial real estate in Onondaga County, NY begin at $1.57 SF/Yr, with an average of $12 SF/Yr and extend to $28 SF/Yr.
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