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    York County, ME Commercial Real Estate for Lease

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    Portland, ME South Portland, ME Lewiston, ME
    74 results
    Medical Office Suite with Waiting Area
    $21 SF/Yr
    768 SF
    Medical Office Suite with Waiting Area

    62 Portland Rd, Kennebunk, ME 4043

    Well-appointed office spaces with a shared waiting area, suitable for therapist use and flexible suite configurations.
    • Well‑appointed office spaces with a common waiting area
    • Suitable for therapist use
    • Can be divided into a 500+ SF suite and a 268+ SF suite
    Updated: Jun 1
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    Renovated Office Space Available
    $875/Mo
    1,500 SF
    Renovated Office Space Available

    860 Main St, Sanford, ME

    Renovated office space for lease with flexible configurations.
    • Newly renovated space with elegant gloss flooring and new heating/AC pumps.
    • Flexible configurations possible for office or retail use (600, 800, or 1500 +/- SF).
    • Excellent street visibility and ample signage space.
    • On‑site and street parking available.
    • Includes private offices, bathrooms, and a large open area.
    Updated: Nov 24, 2025
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    Retail Space Available For Rent
    $14 SF/Yr
    4,000 SF
    Retail Space Available For Rent

    4,000 SF retail space available in October 2026.

    1458 Main Street, Sanford, ME 4073

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    Kennebunk Retail/Office Space Available
    $20 SF/Yr
    2,600 SF
    Kennebunk Retail/Office Space Available

    Retail and office suites available in Kennebunk's Lower Village.

    169 Port Rd, Kennebunk, ME

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    Prime Retail Space Available
    $2,400/Mo
    1,000 SF
    Prime Retail Space Available

    1,000 SF retail space in high-traffic Biddeford location.

    299 Main St, Biddeford, ME

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    Riverfront Retail Space in Biddeford
    $8 SF/Yr
    2,249 SF
    Riverfront Retail Space in Biddeford

    2,249± sf retail space along the Riverfront in Biddeford.

    28 Pearl Street, Biddeford, ME

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    Renovated Church Building Lower Level
    $11 SF/Yr
    7,651 SF
    Renovated Church Building Lower Level

    Renovated lower-level space with unique features available for lease.

    75 Bacon St, Biddeford, ME

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    Main Street Retail Space Available
    $14 SF/Yr
    1,100 SF
    Main Street Retail Space Available

    Retail space in a mini mall with ample parking.

    1299 Main St, Sanford, ME

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    Kittery Retail Space on Route 1
    $12 SF/Yr
    6,555 SF
    Kittery Retail Space on Route 1

    Retail units available in established Kittery retail corridor.

    283 Us Route 1, Kittery, ME 3904

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    Saco Medical Office Suite
    $13 SF/Yr
    10,000 SF
    Saco Medical Office Suite

    10,000± SF medical office suite for rent.

    655 Main St, Saco, ME

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    Flex/Office Building Near Route 1
    $1,750/Mo
    2,000 SF
    Flex/Office Building Near Route 1

    Multi-tenanted flex/office building with easy access to I-95.

    39 Limerick Rd, Arundel, ME

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    Downtown Biddeford Commercial Studio Space
    $1,300/Mo
    954 SF
    Downtown Biddeford Commercial Studio Space

    Commercial studio space in downtown Biddeford, ideal for manufacturing.

    22 Pearl St, Biddeford, ME

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    Medical Office Condo For Lease
    $2,100/Mo
    1,088 SF
    Medical Office Condo For Lease

    Single-story medical office condo adjacent to SMHC Hospital.

    2 Medical Center Dr, Biddeford, ME

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    Professional Office Suites For Rent
    $15 SF/Yr
    1,602 SF
    Professional Office Suites For Rent

    Professional office suites in high-traffic location near downtown Kennebunk.

    3-7 Webhannet Pl, Kennebunk, ME

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    Retail Space in Kittery, Maine
    Contact for pricing
    22,544 SF
    Retail Space in Kittery, Maine

    Retail space available in Kittery, Maine, near popular beaches.

    283 US Route 1, Kittery, ME 3904

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    Kennebunk Office Space For Rent
    $27 SF/Yr
    3,134 SF
    Kennebunk Office Space For Rent

    Office space with open floor plan and architectural details.

    4 Main St, Kennebunk, ME

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    York Office Space For Lease
    Contact for pricing
    3,200 SF
    York Office Space For Lease

    3,200 SF office space in the heart of York Town.

    16 Long Sands Rd, York, ME 3909

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    York, ME Office Space
    $1,950/Mo
    900 SF
    York, ME Office Space

    Office space for lease in York, ME with parking.

    226 York Street, York, ME

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    Retail/Office Space on Route 202
    $12 SF/Yr
    2,688 SF
    Retail/Office Space on Route 202

    Two-story retail or office space available for rent.

    400 Narragansett Trl, Buxton, ME

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    Retail Space in Colonial Square
    $17 SF/Yr
    1,500 SF
    Retail Space in Colonial Square

    Commercial space for lease with high traffic and visibility.

    952 Post Rd, Wells, ME

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    Kennebunk Retail Development Opportunity
    $45 SF/Yr
    15,000 SF
    Kennebunk Retail Development Opportunity

    Proposed retail development with drive-thru and shop space available.

    70-72 Portland Rd, Kennebunk, ME

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    Historic Mill Campus Commercial Space
    $16 SF/Yr
    630 SF
    Historic Mill Campus Commercial Space

    Revitalized mill campus offering flexible commercial suites for lease.

    2 Main St Ste 37-101, Biddeford, ME

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    Biddeford Warehouse with Grow Rooms
    $10 SF/Yr
    5,250 SF
    Biddeford Warehouse with Grow Rooms

    5,250 SF warehouse space suitable for various uses.

    10 Arctic Circle, Biddeford, ME

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    Downtown Saco Office Space Available
    $18 SF/Yr
    1,772 SF
    Downtown Saco Office Space Available

    Office/studio space for rent in downtown Saco.

    209 Main Street, Saco, ME

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    York County, ME Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in York County, ME with 74 listings featured on our commercial real estate exchange. The current inventory includes 656,969 square feet of properties with an estimated lease value of $725 /Mo.

    Estimated lease rates for Commercial real estate in York County, ME begin at $6 SF/Yr, with an average of $16 SF/Yr and extend to $45 SF/Yr.
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