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    Hyannis, MA Commercial Real Estate for Lease

    20 results
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    Main Street Retail and Residence
    $46,200
    2,112 SF

    Main Street Retail and Residence

    547 Main St, Hyannis, MA 02601

    Prime Hyannis location with retail space and on-site residence.

    • Prime Main Street Hyannis location with high year‑round foot traffic and strong summer tourism.
    • Completely rebuilt from the studs out with new walls, ceilings, flooring, plumbing, electrical, HVAC, and finishes.
    • Rare combination of ground‑floor retail space with an on‑site, modern apartment.
    • Open, flexible retail layout with high ceilings and large display windows.
    • Ideal for owner‑operator with living space above the retail business.
    Updated: Jan 7
    View details
    Main Street Retail Opportunity
    $49,020
    2,228 SF

    Main Street Retail Opportunity

    615 Main St, Hyannis, MA 02601

    Prime retail or restaurant space in Hyannis, Massachusetts.

    • Prime location on historic Main Street in Hyannis, Cape Cod, with high car and foot traffic.
    • Versatile 2,200 sq ft space suitable for restaurant, retail, or office use.
    • Located in the Hyannis Main Street Business Improvement District (BID), promoting a clean, safe, and economically developed environment.
    • Walking distance to Nantucket Sound beaches and the Melody Tent.
    • Close proximity to Main Street attractions, Cape Cod Hospital, and ferry service to the islands.
    Updated: Dec 23, 2025
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    Downtown Hyannis Retail Space Available
    $2,325 / Mo
    16,184 SF

    Downtown Hyannis Retail Space Available

    900 SF open retail space on Main Street.

    357 Main St, Hyannis, MA 02601
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    Restaurant Space in Hyannis
    $82,800
    4,259 SF

    Restaurant Space in Hyannis

    Turnkey restaurant space with full commercial kitchen in Hyannis.

    615 Main St, Hyannis, MA 02601
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    Prime Hyannis Retail Space Available
    $2,475 / Mo
    1,188 SF

    Prime Hyannis Retail Space Available

    1,200 sq ft retail space in meticulously maintained complex.

    11 Enterprise Rd, Hyannis, MA 02601
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    Prime Retail Space in Hyannis
    $21 SF/Yr
    3,300 SF

    Prime Retail Space in Hyannis

    Spacious 3,300 SF retail space in downtown Hyannis.

    426 Main St, Hyannis, MA 02601
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    Hyannis Office and Showroom Space
    $23 SF/Yr
    7,792 SF

    Hyannis Office and Showroom Space

    Expansive unit with office, showroom, and gym potential.

    1047 Falmouth Rd, Hyannis, MA 02601
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    Hyannis Office Space Available
    $1,900 / Mo
    7,792 SF

    Hyannis Office Space Available

    Office space for rent in Hyannis, Massachusetts.

    1047 Falmouth Rd, Hyannis, MA 02601
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    Hyannis Office Space For Rent
    $900 / Mo
    7,792 SF

    Hyannis Office Space For Rent

    Office space available in Hyannis, Massachusetts.

    1047 Falmouth Rd, Hyannis, MA 02601
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    Hyannis Restaurant Space For Lease
    $0.02 SF/Yr
    1,860 SF

    Hyannis Restaurant Space For Lease

    High-traffic corner, 1860 sq ft, approved site plan.

    215 Main Street Hyannis, MA 02601, Hyannis, MA 02601
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    Retail Space Available For Lease
    $5,999 / Mo
    4,200 SF

    Retail Space Available For Lease

    Retail space available for lease, totaling 4,200 square feet.

    431 Yarmouth Rd, Hyannis, MA 02601
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    Retail Space in Hyannis
    Contact for pricing
    25,208 SF

    Retail Space in Hyannis

    Retail property for lease in high-traffic Cape Cod location.

    65 Independence Dr, Hyannis, MA
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    Prime Retail Space on Main
    $3,998 / Mo
    2,175 SF

    Prime Retail Space on Main

    Retail space in bustling Hyannis 400 Block on Main.

    388-408 Main St, Hyannis, MA 02668
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    Commercial Condominium For Lease
    $525,000
    972 SF

    Commercial Condominium For Lease

    Commercial condominium for lease with option to purchase.

    68 Ctr St, Hyannis, MA
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    Downtown Hyannis Commercial Property
    $3,500 / Mo

    Downtown Hyannis Commercial Property

    Versatile commercial property in downtown Hyannis with multiple use potential.

    17 School St, Hyannis, MA 02601
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    Hyannis Retail Space Available
    $950 / Mo
    1,200 SF

    Hyannis Retail Space Available

    Retail space in busy strip mall off the highway.

    696-700 Yarmouth Rd, Hyannis, MA
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    Professional Office Space For Rent
    $1,900 / Mo

    Professional Office Space For Rent

    2,380 SF office space in dynamic commercial corridor.

    5 Mark Ln, Hyannis, MA 02601
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    Class A Business Bay
    $18 SF/Yr
    3,640 SF

    Class A Business Bay

    Immaculate industrial bay with high visibility and modern amenities.

    155 Rosary Ln, Hyannis, MA
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    Hyannis Plaza Retail Space
    $19 SF/Yr
    1,500 SF

    Hyannis Plaza Retail Space

    Retail unit in Hyannis Plaza with open floor plan.

    489 Bearses Way, Hyannis, MA
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    Hyannis Office Suite For Rent
    $1,500 / Mo
    1,800 SF

    Hyannis Office Suite For Rent

    1800 sq ft office suite with recent renovations.

    5 Mark Ln, Hyannis, MA
    View details
    Based on your search, we've compiled 39 Potential Opportunities for your consideration. Besides 20 Active listings in Hyannis, MA, we suggest exploring alternatives. Similar 19 Properties for Sales.

    Explore Similar Spaces for Sale in Hyannis, MA

    Consider Similar Space for Sale. We found 19 Spaces in Nearby Locations matching your search parameters.

    Turn-Key Investment in Hyannis, MA
    $2,000,000
    3,415 SF

    Turn-Key Investment in Hyannis, MA

    Fully renewed mixed-use property with immediate income potential.

    712 Main St, Hyannis, MA 02601
    View details
    Downtown Hyannis Mixed-Use Property
    $1,285,000
    4,032 SF

    Downtown Hyannis Mixed-Use Property

    Turnkey mixed-use property with buildable lot in downtown Hyannis.

    574 Main St, Hyannis, MA 02601
    View details
    Versatile Commercial Property in Hyannis
    $899,000
    4,033 SF

    Versatile Commercial Property in Hyannis

    High-visibility commercial property with flexible space in a vibrant location.

    307 Falmouth Rd, Hyannis, MA 02601
    View details
    Hyannis Retail Property For Sale
    $599,000
    2,822 SF

    Hyannis Retail Property For Sale

    Retail property in Hyannis, MA, with redevelopment potential.

    181 Spring St, Hyannis, MA 02601
    View details

    Hyannis, MA Commercial Real Estate Leasing Opportunities Market Analysis

    Explore Commercial Real Estate leasing options in Hyannis, MA with 39 listings featured on our commercial real estate exchange. The current inventory includes 2,614,776,120 square feet of properties with an estimated lease value of $3,671 /Mo.

    Estimated lease rates for Commercial Real Estate in Hyannis, MA begin at $1.39 SF/Yr, with an average of $282 SF/Yr and extend to $3,500 /Mo.

    In Hyannis, MA, current lease rates show:

    • Individual retail properties positioned at $17
    • Retail properties measuring $17
    • Retail space assessed at $16
    • Office Properties & Spaces calculated at $707
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    Browse Commercial real estate for Lease Near Hyannis, MA

    Popular Searches in Hyannis, MA

    Most Searched ZIP Codes in Hyannis, MA

    • 02601
    • 02668

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