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    Barnstable, MA Commercial Real Estate for Lease

    44 results
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    New Retail/Restaurant Space Available
    $33 SF/Yr
    4,533 SF

    New Retail/Restaurant Space Available

    378B Barnstable Rd, Barnstable, MA 02630

    New construction retail/restaurant space at Staples Plaza in Hyannis.

    • Prime location at the Airport Rotary (Rt 28, Rt 132, Barnstable Rd intersection) within a major retail hub.
    • New construction (2025) retail/restaurant space in Staples Plaza.
    • High traffic counts, exceptional frontage, and prominent signage opportunities.
    • Vanilla box delivery allows for customized tenant buildout.
    • Located across from Barnstable Municipal Airport and near US Route 6 exits, downtown Hyannis, and Island Ferry Service.
    Updated: Dec 29, 2025
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    Main Street Retail Opportunity
    $49,020
    2,228 SF

    Main Street Retail Opportunity

    615 Main St, Hyannis, MA 02601

    Prime retail or restaurant space in Hyannis, Massachusetts.

    • Prime location on historic Main Street in Hyannis, Cape Cod, with high car and foot traffic.
    • Versatile 2,200 sq ft space suitable for restaurant, retail, or office use.
    • Located in the Hyannis Main Street Business Improvement District (BID), promoting a clean, safe, and economically developed environment.
    • Walking distance to Nantucket Sound beaches and the Melody Tent.
    • Close proximity to Main Street attractions, Cape Cod Hospital, and ferry service to the islands.
    Updated: Dec 23, 2025
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    Downtown Hyannis Retail Space Available
    $2,325 / Mo
    16,184 SF

    Downtown Hyannis Retail Space Available

    900 SF open retail space on Main Street.

    357 Main St, Hyannis, MA 02601
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    Restaurant Space in Hyannis
    $82,800
    4,259 SF

    Restaurant Space in Hyannis

    Turnkey restaurant space with full commercial kitchen in Hyannis.

    615 Main St, Hyannis, MA 02601
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    Prime Hyannis Retail Space Available
    $2,475 / Mo
    1,188 SF

    Prime Hyannis Retail Space Available

    1,200 sq ft retail space in meticulously maintained complex.

    11 Enterprise Rd, Hyannis, MA 02601
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    Prime Retail Space in Hyannis
    $21 SF/Yr
    3,300 SF

    Prime Retail Space in Hyannis

    Spacious 3,300 SF retail space in downtown Hyannis.

    426 Main St, Hyannis, MA 02601
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    Hyannis Office and Showroom Space
    $23 SF/Yr
    7,792 SF

    Hyannis Office and Showroom Space

    Expansive unit with office, showroom, and gym potential.

    1047 Falmouth Rd, Hyannis, MA 02601
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    Hyannis Office Space Available
    $1,900 / Mo
    7,792 SF

    Hyannis Office Space Available

    Office space for rent in Hyannis, Massachusetts.

    1047 Falmouth Rd, Hyannis, MA 02601
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    Hyannis Office Space For Rent
    $900 / Mo
    7,792 SF

    Hyannis Office Space For Rent

    Office space available in Hyannis, Massachusetts.

    1047 Falmouth Rd, Hyannis, MA 02601
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    Main Street Retail and Residence
    $46,200
    2,112 SF

    Main Street Retail and Residence

    Prime Hyannis location with retail space and on-site residence.

    547 Main St, Hyannis, MA 02601
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    Barnstable Commercial Condominium For Lease
    $22 SF/Yr
    972 SF

    Barnstable Commercial Condominium For Lease

    Commercial condominium for lease in a Class A building.

    68 Ctr St, Barnstable, MA 02630
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    Retail Unit in Hyannis Plaza
    $2,438 / Mo
    1,500 SF

    Retail Unit in Hyannis Plaza

    Retail space for lease in Hyannis Plaza, Barnstable, MA.

    317 Falmouth Rd, Barnstable, MA 02630
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    Osterville Office Space For Rent
    $52,470
    1,600 SF

    Osterville Office Space For Rent

    Prime 1,600 SF office space in desirable Osterville location.

    804 Main St, Osterville, MA 02655
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    Downtown Hyannis Commercial Property For Rent
    $3,500 / Mo
    1,464 SF

    Downtown Hyannis Commercial Property For Rent

    Versatile commercial space in downtown Hyannis, suitable for various uses.

    17 School St, Hyannis, MA 02601
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    Former Craigville General Store Opportunity
    $1,900 / Mo
    1,736 SF

    Former Craigville General Store Opportunity

    Mixed-use property in Centerville, moments from beaches and high traffic.

    628 Craigville Beach Rd, Centerville, MA 02632
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    Barnstable Office Space For Rent
    Pending
    $650 / Mo
    418 SF

    Barnstable Office Space For Rent

    Newly renovated 418 SF office space in Barnstable, MA.

    1645 Falmouth Rd, Barnstable, MA 02630
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    Versatile Commercial Space in Hyannis
    $3,600 / Mo
    5,348 SF

    Versatile Commercial Space in Hyannis

    Flexible commercial space in downtown Hyannis, ready for customization.

    328 Main St, Hyannis, MA 02601
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    Hyannis Restaurant Space For Lease
    $0.02 SF/Yr
    1,860 SF

    Hyannis Restaurant Space For Lease

    High-traffic corner, 1860 sq ft, approved site plan.

    215 Main Street Hyannis, MA 02601, Hyannis, MA 02601
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    Retail Space Available For Lease
    $5,999 / Mo
    4,200 SF

    Retail Space Available For Lease

    Retail space available for lease, totaling 4,200 square feet.

    431 Yarmouth Rd, Hyannis, MA 02601
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    Osterville Office Space For Rent
    $1,800 / Mo
    1,000 SF

    Osterville Office Space For Rent

    Professional office suite in desirable Osterville, Cape Cod.

    5 Parker Rd, Barnstable, MA 02655
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    Medical Office Space Near Hospital
    $3,500 / Mo
    1,864 SF

    Medical Office Space Near Hospital

    Prime medical office space in Hyannis near Cape Cod Hospital.

    51 Main St, Barnstable, MA 02601
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    Prime Retail Space on Main
    $19 SF/Yr

    Prime Retail Space on Main

    Spacious retail space in the heart of downtown Hyannis.

    426 Main St, Barnstable, MA 02601
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    Centerville Office Space For Lease
    $0.10 SF/Yr
    2,189 SF

    Centerville Office Space For Lease

    Prime location, 2189 sq ft, single tenant.

    889 Main St, Barnstable, MA 02630
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    Prime Hyannis Office/Retail Space
    $16 SF/Yr
    7,420 SF

    Prime Hyannis Office/Retail Space

    7,420 SF, Drive-Thru, High Visibility

    749 Main St, Barnstable, MA 02601
    View details

    Barnstable, MA Commercial Real Estate Leasing Opportunities Market Analysis

    Explore Commercial Real Estate leasing options in Barnstable, MA with 83 listings featured on our commercial real estate exchange. The current inventory includes 4,538,864,880 square feet of properties with an estimated lease value of $111,228.

    Estimated lease rates for Commercial Real Estate in Barnstable, MA begin at $1.39 SF/Yr, with an average of $3,588 /Mo and extend to $52,470.

    In Barnstable, MA, current lease rates show:

    • Retail properties positioned at $3,199
    • Office Properties & Spaces measuring $3,555
    • Individual retail properties assessed at $3,623
    • Office space calculated at $4,060
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    Browse Commercial real estate for Lease Near Barnstable, MA

    Popular Searches in Barnstable, MA

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    Most Searched ZIP Codes in Barnstable, MA

    • 02601
    • 02630
    • 02655
    • 02668
    • 02632
    • 02648
    • 02675

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