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    Matlacha Isles, FL

    Matlacha Isles, FL Commercial Real Estate for Lease

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    118 properties
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    Upstairs Office Unit with High Ceilings
    Updated: Sep 10
    Upstairs Office Unit with High Ceilings

    1322 SE 46th Lane, Cape Coral, FL 33904

    $1,150/Mo
    0.22 AC lot
    Upstairs office unit with high ceilings
    Separate office areas provide privacy
    Abundant natural light throughout the space
    Move‑in‑ready condition
    Located in Downtown Cape Coral
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    First-Floor Office Suite
    Updated: Aug 16
    First-Floor Office Suite

    1325 SE 47th Street, Cape Coral, FL 33904

    $2,750/Mo
    0.17 AC lot
    1,186 SF first‑floor office suite
    Open lobby and reception area with vaulted ceilings
    Three private offices and a conference room
    Kitchenette plus large storage closet/file station
    South‑facing windows overlooking the parking lot
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    8-Office Professional Suite
    8-Office Professional Suite

    2503 Del prado Boulevard, Cape Coral, FL 33904

    $5,200/Mo
    1.99 AC lot

    Sublease space includes a conference room, full kitchen, and upgraded interior finishes.

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    Retail Endcap with Office Suite
    Retail Endcap with Office Suite

    643 Cape Coral Pkwy E, Cape Coral, FL 33904

    $32 SF/Yr
    3,000 sqft

    Two lease configurations provide built-out offices or open commercial space for retail, service, restaurant, and office uses.

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    Flex Space with Office and Warehouse
    Flex Space with Office and Warehouse

    4519 SE 16th Place, Cape Coral, FL 33904

    $3,000/Mo
    0.41 AC lot

    Lease space combines an air-conditioned office, warehouse area, overhead loading door, and dedicated parking.

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    Renovated Office Unit
    Renovated Office Unit

    1314 Cape Coral Parkway E, Cape Coral, FL 33904

    $1,280/Mo
    0.09 AC lot

    Updated workspace with private restroom, kitchenette, central air, and efficient LED lighting.

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    Private-Office Coworking Space
    Private-Office Coworking Space

    4706 Chiquita Boulevard S, Cape Coral, FL 33914

    $585/Mo per office
    1.00 AC lot

    Business-center setting with 24/7 access, conference facilities, mail services, Wi-Fi, and on-site parking.

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    Renovated Flex Space with Private Restroom
    Renovated Flex Space with Private Restroom

    1416 Lafayette St Unit 2, Cape Coral, FL 33904

    $1,600/Mo
    3,750 sqft

    Unit 2 combines front reception space with a separate air-conditioned rear work area.

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    Second-Floor Office Unit
    Second-Floor Office Unit

    1031 Cape Coral Parkway E, Cape Coral, FL 33904

    $2,200/Mo
    0.16 AC lot

    The suite has a separate bathroom and parking at both the front and rear of the building.

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    Ground-Floor Office Suite
    Ground-Floor Office Suite

    4645 SE 15th Avenue, Cape Coral, FL 33904

    $1,805/Mo
    0.16 AC lot

    Three private offices, two bathrooms, and a full kitchen are complemented by included utilities.

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    Retail Space with New Finishes
    Retail Space with New Finishes

    1910 Del Prado Boulevard S, Cape Coral, FL 33990

    $22 SF/Yr
    2,850 sqft

    C1 Commercial zoning, alley service access, and convenient entry from Del Prado Boulevard support retail use.

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    Office Units with Two Bathrooms
    Office Units with Two Bathrooms

    131 Del Prado Boulevard S, Cape Coral, FL 33990

    $3,800/Mo
    0.34 AC lot

    Office space available for rent along Del Prado Boulevard with a two-bathroom layout.

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    Renovated Office Unit
    Renovated Office Unit

    1416 Lafayette Street, Cape Coral, FL 33904

    $1,600/Mo
    0.21 AC lot

    Unit 2 combines a reception area, private restroom, and separate air-conditioned rear workspace or storage area.

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    Remodeled Medical Office Space
    Remodeled Medical Office Space

    1224 Del Prado Boulevard S C, Cape Coral, FL 33990

    $16 SF/Yr
    3,352 sqft

    Updated professional space combines medical functionality, reception, storage, and dedicated parking.

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    Flex Space with Warehouse Doors
    Flex Space with Warehouse Doors

    954 Country Club Boulevard, Cape Coral, FL 33990

    $4,150/Mo
    0.42 AC lot

    Includes office rooms, a conference room, and open warehouse space.

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    Office Units Near Midpoint Bridge
    Office Units Near Midpoint Bridge

    2930 Del Prado Boulevard S, Cape Coral, FL 33904

    $1,575/Mo
    0.34 AC lot

    Cape Coral office space along Del Prado Boulevard S, positioned south of the Midpoint Bridge.

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    Renovated Flex Industrial Building
    Renovated Flex Industrial Building

    1002 SE 9th St, Cape Coral, FL 33990

    $18 SF/Yr
    4,500 sqft

    Light industrial space with updated offices, three-phase power, and a paved, fenced area for parking or outside storage.

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    Medical Office Space
    Medical Office Space

    822 Del Prado Boulevard S, Cape Coral, FL 33990

    $21 SF/Yr
    0.97 AC lot

    A medical office at Del Prado Boulevard and Viscaya Parkway is available for lease.

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    Second-Floor Office Unit
    Second-Floor Office Unit

    923 Del Prado Boulevard S Unit 203, Cape Coral, FL 33990

    $2,450/Mo
    1,015 sqft

    Configured with private offices, a conference room, reception area, kitchenette, and storage.

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    Second-Floor Office Units
    Second-Floor Office Units

    3613 Del Prado Boulevard S, Cape Coral, FL 33904

    $3,200/Mo
    0.34 AC lot

    Layout includes four enclosed offices and one large open area.

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    Office Suites with Canal Views
    Office Suites with Canal Views

    2804 Del Prado Boulevard S Unit 106, Cape Coral, FL 33904

    $1,975/Mo
    1,000 sqft

    Two professional office units offer distinct layouts across the first and second floors of a 1986 commercial building.

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    Retail Space with Open Layout
    Retail Space with Open Layout

    814 SW Pine Island Road, Cape Coral, FL 33991

    $2,500-$5,000/Mo
    3.65 AC lot

    Flexible retail or office premises with showroom space, two bathrooms, dual HVAC, signage options, and parking at a multi-tenant center.

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    Retail Space in Merchants Plaza
    Retail Space in Merchants Plaza

    159 Hancock Bridge Parkway 8-10, Cape Coral, FL 33990

    $22 SF/Yr
    3,200 sqft

    3,200 sq ft retail space available February 2026.

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    Retail Space with Parkway Frontage
    Retail Space with Parkway Frontage

    159 Hancock Bridge Parkway, Cape Coral, FL 33990

    $22 SF/Yr
    1.20 AC lot

    Open retail layout with private office, two restrooms, glass frontage, and multiple access points.

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    Matlacha Isles, FL Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in Matlacha Isles, FL with 118 listings featured on our commercial real estate exchange. The current inventory includes 538,234 square feet of properties with an estimated lease value of $908.43.

    Estimated lease rates for Commercial real estate in Matlacha Isles, FL begin at $1.77 SF/Yr, with an average of $20.65 SF/Yr and extend to $75 SF/Yr.
    Matlacha Isles, FL CRE market trends — vacancy, lease rates and price per SF, updated monthly
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    Most Searched ZIP Codes in Matlacha Isles, FL

    • 33990
    • 33904
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    • 33991
    • 33914
    • 33993
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