La Crosse, WI Retail Properties & Spaces for Lease

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Updated: Mar 25

Historic Landmark Mixed-Use Development

401 2nd Street North, La Crosse, WI 54601

$8 SF/Yr

22,000 sqft $14,666/Mo

Prime downtown LaCrosse location in the historic Landmark by the Rivers.
Mixed‑use development attracting diverse clientele.
Leasing opportunities for various business types.
Close proximity to hotels and the convention center.
Character‑filled space with vintage brick, reclaimed industrial components, oversized windows, and soaring ceiling heights.

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Updated: Nov 22, 2025

Riverfront Commercial Space Available

104 Causeway Boulevard, La Crosse, WI 54603

$25 SF/Yr

12,518 sqft $26,079/Mo

Unmatched river views
Flexible commercial space from 737 to 12,518 SF
Located in La Crosse’s vibrant, new River Point District
Easy accessibility
51 residential units above, creating built‑in customer base

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Historic Landmark Mixed-Use Development

525 2nd St, La Crosse, WI 54601

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24,000 sqft

Mixed-use development in downtown La Crosse with leasing opportunities.

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Retail Space on Main Street

515 Main St, La Crosse, WI 54601

$15.50 SF/Yr

1,007 sqft $1,300/Mo

Single tenant retail space available for rent.

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Premium Retail Space in La Crosse

341 River Bend Rd |, La Crosse, WI 54603

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2,500 sqft

2,500 SF retail space in growing River Point District.

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Prime Downtown La Crosse Sublease

310 4th Street South, La Crosse, WI 54601

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3,500 sqft

Sublease opportunity in downtown La Crosse with high visibility.

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Downtown La Crosse Retail/Office Space

221 3rd St S, La Crosse, WI 54601

$13 SF/Yr

2,400 sqft $2,600/Mo

Renovated retail/office space in downtown La Crosse with storage.

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Retail Center Near University Campuses

4242-4340 Mormon Coulee Rd, La Crosse, WI

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1,951 sqft

Retail spaces available in La Crosse near universities.

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Mixed-Use Development Leasing Opportunity

401 2nd St N, La Crosse, WI 54601

$14 SF/Yr

Mixed-use development suitable for restaurant, retail, office, or medical tenants.

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Retail Strip Center For Lease

4202 Mormon Coulee Rd, La Crosse, WI 54601

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76,000 sqft

76,000 SF retail strip center in La Crosse, Wisconsin.

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Based on your search, we've compiled 25 Potential Opportunities for your consideration. Besides 10 Active listings in La Crosse, WI, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 7 Properties for Sales.

Retail properties & Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Versatile Office Space For Lease

206 S Roosevelt Road, Black River Falls, WI 54615

$650/Mo

350 sqft $22.29 SF/Yr

650 sq ft office space suitable for various business types.

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Versatile Office Space For Lease

206 S Roosevelt Road, Black River Falls, WI 54615

$770/Mo

695 sqft $13.29 SF/Yr

695 sq ft office space suitable for various businesses.

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Retail Space Near Walmart

37885 Selch Ave, Prairie Du Chien, WI

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2,400 sqft

Retail space available in shadow-anchored shopping center.

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Retail/Restaurant Space for Lease

37885 Selch Rd, Prairie Du Chien, WI 53821

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Retail and restaurant spaces available for lease.

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Similar Spaces for Sale in La Crosse, WI

Consider Similar Space for Sale. We found 7 Spaces matching your search parameters.

Retail Building with Drive-Through

1817 Jackson St, La Crosse, WI 54601

$310,000

2,250 sqft 0.19 AC lot

Retail building with drive-through access and convenient parking in a Commercial-zoned location on a high-traffic corner.

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Historic Mixed-Use Building with Storefronts

423 Main St, La Crosse, WI 54601

$1,150,000

9,000 sqft 0.12 AC lot

Historic downtown mixed-use property with multiple street-level storefront leases and four apartments with established tenants.

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Downtown Auto Service Building

227 3rd St S, La Crosse, WI 54601

Contact for pricing

1,200 sqft 0.24 AC lot

Corner commercial building with a garage wash bay, office and reception space, and onsite parking.

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Historic Mixed-Use Downtown Building

423 Main St Unit 425 & 427, La Crosse, WI 54601

$1,150,000

3,000 sqft

Built in 1880, the property combines street-level storefronts with leased apartments above for an all-leased operating setup.

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High-Visibility Retail Space Available

1601 Jackson Street, La Crosse, WI 54601

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2,700 sqft

2,700 sq ft retail space with excellent exposure.

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Renovated Downtown Retail Storefront

221 3rd St S, La Crosse, WI 54601

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2,000 sqft 0.24 AC lot

Newly renovated storefront includes updated HVAC, electrical, insulation, drywall, and new display windows with ADA bathroom.

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Highway Retail Opportunity Available

3900 Wisconsin Highway 16 |, La Crosse, WI 54601

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Land available for purchase, ground lease, or build-to-suit development.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Development Site Available For Lease

4107 Mormon Coulee Rd |, La Crosse, WI 54601

Contact for pricing

0.7 AC development site available for lease or sale.

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Retail/Office Space For Lease

1501 Johnson St NE |, Minneapolis, MN 55413

$40 SF/Yr

Retail/office space for lease or build to suit.

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Waukee Pad Site For Lease

405 E Hickman Rd, Waukee, IA 50263

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1.1-acre pad site available for ground lease or build-to-suit.

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Plainfield Commercial Land For Rent

SW corner of Rte 59 & Fraser Road, Plainfield, IL 60586

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6.491 acre commercial land available for rent in Plainfield, IL.

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La Crosse, WI Retail properties & Spaces Market Trends and Statistics

Explore Retail properties & Spaces leasing options in La Crosse, WI with 10 listings featured on our commercial real estate exchange. The current inventory includes 37,925 square feet of properties with an estimated lease value of $61.50 SF/Yr.

Estimated lease rates for Retail properties & Spaces in La Crosse, WI begin at $8 SF/Yr, with an average of $15.38 SF/Yr and extend to $25 SF/Yr.

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