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    Yankton County, SD Office Properties & Spaces for Sale

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    Industrial Building on Highway 50
    $1,395,000
    11.99 Acres

    Industrial Building on Highway 50

    3704 E. SD Hwy 50, Yankton, SD 57078

    23,115 sq. ft. industrial building on 11.99 acres.

    • Substantial 23,115 sq. ft. industrial building
    • Large 11.99 +/- acre property
    • Excellent location on a heavily traveled highway
    • Ample truck access with 11 overhead doors
    • Large 13,000 sq. ft. warehouse featuring a 22‑foot clear height
    Updated: Sep 26, 2025
    View details
    Downtown Yankton Mixed-Use Opportunity
    $295,000
    5,336 SF

    Downtown Yankton Mixed-Use Opportunity

    321 Douglas Ave, Yankton, SD 57078

    Two-story building with retail and residential/commercial potential.

    • Prime downtown Yankton location with high visibility and walkable access to the commercial core.
    • Over 5,300 sq ft of flexible space suitable for retail, office, studio, or residential use.
    • Mixed‑use opportunity for investors or owner‑operators with income potential from upper level.
    • Adaptable 3,800+ sq ft main floor previously used as a dance studio, ready for customization.
    • Value‑add potential for redevelopment or continued studio‑style use.
    Updated: Mar 12
    View details
    Based on your search, we've compiled 120 Potential Opportunities for your consideration. Besides 2 Active listings in Yankton County, SD, we suggest exploring several alternatives: similar 114 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Elk Point Commercial Lot
    $87,352
    0.51 Acres

    Elk Point Commercial Lot

    Half-acre commercial lot with high visibility in Elk Point.

    2001 Jack Nicklaus Dr., Elk Point, SD 57025
    View details
    Commercial Lot in Growing Tea
    $220,000
    0.68 Acres

    Commercial Lot in Growing Tea

    High-visibility commercial lot in a high-growth Sioux Falls metro area.

    500 N Heritage Pkwy, Tea, SD 57064
    View details
    Undeveloped Land in Sioux Falls
    $7,960,000
    45.53 Acres

    Undeveloped Land in Sioux Falls

    Large land parcel with development potential in expanding Sioux Falls.

    27002 S Louise Ave, Sioux Falls, SD 57108
    View details
    Prime Commercial Space in Sioux City
    Contact for pricing
    2.08 Acres

    Prime Commercial Space in Sioux City

    Blank canvas in downtown Sioux City with high visibility.

    130 Nebraska St, Suite A, Sioux City, IA 51101
    View details

    Explore Off-Market Properties in Yankton County, SD

    Consider similar Off-Market properties in Yankton County, SD. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    420 Broadway Ave

    420 Broadway Ave

    OFFICE BUILDING • 2,640 SF
    Value Estimation by Request
    420 Broadway Ave, Yankton, SD 57078-4305
    View details
    918 Hwy 50

    918 Hwy 50

    OFFICE BUILDING • 1,050 SF
    Value Estimation by Request
    918 Hwy 50, Yankton, SD 57078
    View details
    101 2nd St

    101 2nd St

    OFFICE BUILDING • 11,400 SF
    Value Estimation by Request
    101 2nd St, Yankton, SD 57078-4314
    View details
    319 Walnut St

    319 Walnut St

    OFFICE BUILDING • 14,614 SF
    Value Estimation by Request
    319 Walnut St, Yankton, SD 57078-4344
    View details
    31105 436th Ave

    31105 436th Ave

    PROFESSIONAL BUILDING • 864 SF
    Value Estimation by Request
    31105 436th Ave, Yankton, SD 57078-5960
    View details
    603 21st St

    603 21st St

    OFFICE BUILDING • 1,584 SF
    Value Estimation by Request
    603 21st St, Yankton, SD 57078-2086
    View details
    201 Broadway Ave

    201 Broadway Ave

    OFFICE BUILDING • 1,700 SF
    Value Estimation by Request
    201 Broadway Ave, Yankton, SD 57078-4211
    View details
    610 23rd St

    610 23rd St

    OFFICE BUILDING • 15,084 SF
    Value Estimation
    $1,405,000
    610 23rd St, Yankton, SD 57078-1218
    View details
    2006 Locust St

    2006 Locust St

    OFFICE BUILDING • 936 SF
    Value Estimation by Request
    2006 Locust St, Yankton, SD 57078-2031
    View details
    402 3rd St

    402 3rd St

    OFFICE BUILDING • 2,640 SF
    Value Estimation by Request
    402 3rd St, Yankton, SD 57078-4513
    View details
    1603 Locust St

    1603 Locust St

    OFFICE BUILDING • 5,100 SF
    Value Estimation by Request
    1603 Locust St, Yankton, SD 57078-2017
    View details
    606 Goeden Dr

    606 Goeden Dr

    OFFICE BUILDING • 3,584 SF
    Value Estimation by Request
    606 Goeden Dr, Yankton, SD 57078-2083
    View details
    800 Burleigh St

    800 Burleigh St

    OFFICE BUILDING • 982 SF
    Value Estimation by Request
    800 Burleigh St, Yankton, SD 57078-3197
    View details
    904 23rd St

    904 23rd St

    OFFICE BUILDING • 20,388 SF
    Value Estimation by Request
    904 23rd St, Yankton, SD 57078-1216
    View details
    2300 15th St

    2300 15th St

    OFFICE BUILDING • 1,344 SF
    Value Estimation by Request
    2300 15th St, Yankton, SD 57078-6543
    View details
    614 Broadway Ave

    614 Broadway Ave

    OFFICE BUILDING • 5,772 SF
    Value Estimation by Request
    614 Broadway Ave, Yankton, SD 57078-3516
    View details
    216 3rd St

    216 3rd St

    OFFICE BUILDING • 2,256 SF
    Value Estimation by Request
    216 3rd St, Yankton, SD 57078-4323
    View details
    3608 Hwy 50

    3608 Hwy 50

    OFFICE BUILDING • 7,000 SF
    Value Estimation
    $795,000
    3608 Hwy 50, Yankton, SD 57078-6526
    View details
    809 Belfast St

    809 Belfast St

    MEDICAL BUILDING • 2,482 SF
    Value Estimation by Request
    809 Belfast St, Yankton, SD 57078-3324
    View details
    207 Douglas Ave

    207 Douglas Ave

    OFFICE BUILDING • 7,560 SF
    Value Estimation by Request
    207 Douglas Ave, Yankton, SD 57078-4338
    View details
    202 2nd St

    202 2nd St

    OFFICE BUILDING • 2,821 SF
    Value Estimation by Request
    202 2nd St, Yankton, SD 57078-4317
    View details
    2001 Broadway Ave

    2001 Broadway Ave

    MEDICAL BUILDING • 2,000 SF
    Value Estimation by Request
    2001 Broadway Ave, Yankton, SD 57078-2032
    View details

    Yankton County, SD Office Properties & Spaces Investment Opportunities Market Analysis

    Explore 116 office properties & spaces for sale in Yankton County, SD on our real estate platform. These investment opportunities span a total of 6,242,442 square feet of properties for sale, with an estimated market value of $29,070,000.

    Sale prices for office spaces in Yankton County, SD start at $55,000, averaging $358,888, and reaching up to $1,500,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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