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    Greenwood County, SC Office Properties & Spaces for Sale

    8 results
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    Versatile Commercial Flex Property
    $799,900
    6,000 SF

    Versatile Commercial Flex Property

    463 Calhoun Ave, Greenwood, SC 29646

    6,000 sq ft commercial flex property in Greenwood, SC.

    • 6,000 sq ft commercial flex property in a thriving commercial district.
    • Potential to reconfigure into 4 units for increased rental income.
    • Currently divided into 3 units (3,000 sq ft, two 1,500 sq ft units) offering immediate income potential.
    • Recently resurfaced parking lot providing ample parking.
    • Ideal for a mix of office, retail, or light industrial use.
    Updated: Mar 17
    View details
    Historic Uptown Greenwood Commercial Property
    $749,000
    4,684 SF

    Historic Uptown Greenwood Commercial Property

    206 Main St, Greenwood, SC 29649

    Versatile commercial space in a vibrant historic district with unique features.

    • Prime Location: Situated in the heart of Uptown Greenwood with high visibility and foot traffic.
    • Versatile Space: Just under 5,000 sqft with a flexible layout suitable for retail, office, or mixed‑use purposes. Includes seven private office suites, a shared kitchenette, and a large basement.
    • Historic Charm: Features original hardwood floors, ghost murals (including a vintage Coca‑Cola mural), and architectural details reflecting its 1917 origins.
    • Ample Parking: Benefits from an expansive city‑owned front lot providing abundant parking.
    • Turnkey Opportunity: Includes all remaining furnishings upstairs, making it ready for a new business/owner.
    Updated: Sep 9, 2025
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    Greenwood Commercial Building with Warehouse
    $395,000
    10,000 SF

    Greenwood Commercial Building with Warehouse

    Office, showroom, and warehouse on a large corner lot.

    1201 Cambridge Ave, Greenwood, SC 29649
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    Versatile Commercial Building, Greenwood SC
    $159,000
    1,722 SF

    Versatile Commercial Building, Greenwood SC

    Adaptable commercial building with high visibility and flexible build-out options.

    1601 E Cambridge Ave, Greenwood, SC 29646
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    Iconic Mixed-Use Property, Greenwood SC
    $479,000
    4,753 SF

    Iconic Mixed-Use Property, Greenwood SC

    Mixed-use property in vibrant Uptown Greenwood, ideal for live/work.

    204 Main St, Greenwood, SC 29649
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    Greenwood Commercial Acreage For Sale
    $350,000
    1.80 Acres

    Greenwood Commercial Acreage For Sale

    1.8 acre commercial lot with high visibility and traffic.

    1421 Cambridge Ave, Greenwood, SC 29646
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    Greenwood Historic Building Fifth Floor
    $50,000
    1,817 SF

    Greenwood Historic Building Fifth Floor

    Fifth floor of historic building suitable for commercial or residential.

    327 Main St, Greenwood, SC 29646
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    Uptown Greenwood Multi-Use Corner Building
    $750,000
    5,308 SF

    Uptown Greenwood Multi-Use Corner Building

    Three-level commercial building with retail, office, and storage space.

    202 Main St, Greenwood, SC 29646
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    Based on your search, we've compiled 12 Potential Opportunities for your consideration. Besides 8 Active listings in Greenwood County, SC, we suggest exploring several alternatives: plus 4 Land Listings that present a potential for development.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Greenwood Commercial Acreage Opportunity
    $4,300,000
    11.46 Acres

    Greenwood Commercial Acreage Opportunity

    11.46 acres zoned C2 in prime Greenwood location.

    508 Old Abbeville Hwy, Greenwood, SC 29646
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    Greenwood Commercial Land For Sale
    $375,000
    1.97 Acres

    Greenwood Commercial Land For Sale

    1.97 acre commercial tract with road frontage.

    1230 Montague Avenue Ext, Greenwood, SC 29649
    View details
    Greenwood Commercial Corner Lot Opportunity
    $174,000
    0.54 Acres

    Greenwood Commercial Corner Lot Opportunity

    Prime commercial corner lot in Greenwood's active corridor.

    441/433 Calhoun Ave, Greenwood, SC 29649
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    Commercial Land on Montague Ave
    $135,000
    0.49 Acres

    Commercial Land on Montague Ave

    Half-acre commercial tract in high-traffic location, ready for business.

    1438 Montague Avenue Ext, Greenwood, SC 29649
    View details

    Explore Off-Market Properties in Greenwood County, SC

    Consider similar Off-Market properties in Greenwood County, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    167 Greenwood Ave

    167 Greenwood Ave

    MEDICAL BUILDING • 6.20 Acres
    Value Estimation by Request
    167 Greenwood Ave, Ware Shoals, SC 29692-1636
    View details
    109 Oak Ave

    109 Oak Ave

    OFFICE BUILDING • 7,618 SF
    Value Estimation by Request
    109 Oak Ave, Greenwood, SC 29646-2624
    View details
    1120 Reynolds Ave

    1120 Reynolds Ave

    OFFICE BUILDING • 6,225 SF
    Value Estimation by Request
    1120 Reynolds Ave, Greenwood, SC 29649-2736
    View details
    1013 Spg St

    1013 Spg St

    MEDICAL BUILDING • 12,541 SF
    Value Estimation by Request
    1013 Spg St, Greenwood, SC 29646
    View details
    1128 Spg St

    1128 Spg St

    MEDICAL BUILDING • 5,062 SF
    Value Estimation by Request
    1128 Spg St, Greenwood, SC 29646-3859
    View details
    17 Greenwood Ave

    17 Greenwood Ave

    MEDICAL BUILDING • 1,760 SF
    Value Estimation by Request
    17 Greenwood Ave, Ware Shoals, SC 29692-1529
    View details
    201 Hampton Ave Ste F

    201 Hampton Ave Ste F

    MEDICAL BUILDING • 1,344 SF
    Value Estimation by Request
    201 Hampton Ave Ste F, Greenwood, SC 29646-2271
    View details
    109 Liner Dr

    109 Liner Dr

    MEDICAL BUILDING • 9,107 SF
    Value Estimation by Request
    109 Liner Dr, Greenwood, SC 29646-2311
    View details
    340 Main St

    340 Main St

    OFFICE BUILDING • 25,376 SF
    Value Estimation
    $1,405,000
    340 Main St, Greenwood, SC 29646-2758
    View details
    1030 Edgefield St

    1030 Edgefield St

    OFFICE BUILDING • 3,354 SF
    Value Estimation by Request
    1030 Edgefield St, Greenwood, SC 29646-3207
    View details
    1823 Calhoun Rd

    1823 Calhoun Rd

    OFFICE BUILDING • 1,456 SF
    Value Estimation by Request
    1823 Calhoun Rd, Greenwood, SC 29649-9102
    View details
    150 Cambridge W Ave

    150 Cambridge W Ave

    MEDICAL BUILDING • 3,898 SF
    Value Estimation by Request
    150 Cambridge W Ave, Greenwood, SC 29646-2234
    View details
    111 Merriman Ave

    111 Merriman Ave

    OFFICE BUILDING • 1,750 SF
    Value Estimation by Request
    111 Merriman Ave, Greenwood, SC 29646-2136
    View details
    104 Venture Ct

    104 Venture Ct

    OFFICE BUILDING • 2,218 SF
    Value Estimation by Request
    104 Venture Ct, Greenwood, SC 29649-8558
    View details
    411 Roseland Dr

    411 Roseland Dr

    OFFICE BUILDING • 1,394 SF
    Value Estimation by Request
    411 Roseland Dr, Greenwood, SC 29649-1456
    View details
    108 Venture Ct

    108 Venture Ct

    OFFICE BUILDING • 2,218 SF
    Value Estimation by Request
    108 Venture Ct, Greenwood, SC 29649-8558
    View details

    Greenwood County, SC Office Properties & Spaces Investment Opportunities Market Analysis

    Explore 245 office properties & spaces for sale in Greenwood County, SC, showcased through 8 active listings on our real estate platform. These investment opportunities span a total of 4,934,390 square feet of properties for sale, with an estimated market value of $45,297,900.

    Sale prices for office spaces in Greenwood County, SC start at $50,000, averaging $924,446, and reaching up to $12,245,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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