Advertise
    Missouri
    Office

    Lafayette County, MO Office Spaces for Lease

    Notify Me
    List
    Map
    Saint Louis, MO Kansas City, MO Springfield, MO Saint Charles, MO Chesterfield, MO Joplin, MO Louis, MO Independence, MO
    Two-Story Medical Office Suites
    Updated: Dec 18, 2025
    Two-Story Medical Office Suites

    316 W US Hwy 40, Odessa, MO 64076

    Contact for pricing
    1,750 sqft
    11,000 SF, two‑story building on a 1.75‑acre lot
    Lower‑level office spaces for rent: 1,750 SF and 2,200 SF
    Street level is 100% occupied by a Medical Group and a Nail Salon
    Ample on‑site parking plus room to add an additional building
    View details
    Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
    Based on your search, we've compiled 24 Potential Opportunities for your consideration. Besides 1 Active listings in Lafayette County, MO, we suggest exploring alternatives. Similar 19 Properties for Sales.

    Similar Spaces for Sale in Lafayette County, MO

    Consider Similar Space for Sale. We found 19 Spaces matching your search parameters.

    Multi-Room Office Space
    Multi-Room Office Space

    213 S 2nd Street, Odessa, MO 64076

    $200,000
    0.07 AC lot

    Flexible office layout with multiple rooms, plus off-street parking and recent HVAC and roof updates.

    View details
    Updated Commercial Building in Lexington
    Updated Commercial Building in Lexington

    206 S 12th Street, Lexington, MO 64067

    $90,000
    900 sqft 0.05 AC lot

    Charming updated commercial building in historic downtown Lexington, Missouri.

    View details
    Renovated Medical Office Building
    Renovated Medical Office Building

    1717 N Main Street, Higginsville, MO 64037

    Contact for pricing
    7,100 sqft

    Fully renovated medical office building with multiple exam rooms, reception, staff workspaces, and four bathrooms.

    View details
    Historic Storefront Building with Freight Elevator
    Historic Storefront Building with Freight Elevator

    1802 Franklin Avenue, Lexington, MO 64067

    $70,000
    0.24 AC lot

    Historic storefront building with freight elevator, 12-foot ceilings, brick courtyard, and C zoning.

    View details
    Higginsville Office Building For Sale
    Higginsville Office Building For Sale

    3401 Pine Street & 810 W. 35th Street, Higginsville, MO 64037

    Contact for pricing
    11,200 sqft

    Office building with 11,200 square feet of space.

    View details
    Two-Level Flex Space with Loading Docks
    Two-Level Flex Space with Loading Docks

    116 W 19TH Street, Higginsville, MO 64037

    $350,000
    0.78 AC lot

    Adjoined buildings combine front offices, rear warehouse space, loading access, and on-site parking.

    View details
    Brick Live-Work Property
    Brick Live-Work Property

    101 W Walnut Street, Waverly, MO 64096

    $140,000
    0.19 AC lot

    Flexible live-work setting with on-site parking and available water service in Waverly.

    View details
    Retail Building with Interstate Exposure
    Retail Building with Interstate Exposure

    202 N Main, Concordia, MO 64020

    Contact for pricing
    1.28 AC lot

    Retail building adjacent to an Interstate 70 down-ramp with on-site signage and strong visibility from west- and east-bound traffic.

    View details
    47,740 SF Mixed-Use Building
    47,740 SF Mixed-Use Building

    1340 E Old Hwy 40, Odessa, MO 64076

    Contact for pricing
    31,060 sqft

    47,740 SF building suitable for industrial, office, retail.

    View details
    Versatile 30,000 SF Multi-Use Building
    Versatile 30,000 SF Multi-Use Building

    1304 E Old Hwy 40, Odessa, MO 64076

    Contact for pricing
    30,000 sqft

    30,000 SF building suitable for industrial, warehouse, office, retail.

    View details
    37,700 SF Mixed-Use Building
    37,700 SF Mixed-Use Building

    1212 U.S. Hwy 40, Odessa, MO 64076

    Contact for pricing
    37,000 sqft

    37,700 SF building suitable for industrial, office, retail, etc.

    View details
    29,700 SF Mixed-Use Building
    29,700 SF Mixed-Use Building

    1252 E Old Hwy 40, Odessa, MO 64076

    Contact for pricing
    29,700 sqft

    29,700 SF building suitable for retail, office, or industrial.

    View details
    Professional Office Space
    Professional Office Space

    213 S 2nd Street, Odessa, MO 64076

    Contact for pricing

    Functional office layout with multiple rooms, plus off-street parking and recent AC and roof updates.

    View details
    Industrial, Mixed Use, Office, Retail, Self Storage
    Industrial, Mixed Use, Office, Retail, Self Storage

    1276 E Old Hwy 40, Odessa, MO 64076

    Contact for pricing
    47,740 sqft

    Mixed-use properties · 47,740 SF

    View details
    Historic Mixed-Use Retail Building
    Historic Mixed-Use Retail Building

    1802 Franklin Avenue, Lexington, MO 64067

    Contact for pricing

    Historic neighborhood store building with a high-ceiling first floor suitable for retail and additional second-floor living or office space.

    View details
    Two-Story Brick Medical Office Building
    Two-Story Brick Medical Office Building

    316 W US Hwy 40, Odessa, MO 64076

    Contact for pricing
    11,000 sqft

    All-brick two-story building with available first-floor office space and an occupied second floor.

    View details
    Maintenance-Free Retail Office Space
    Maintenance-Free Retail Office Space

    408 W 19th St, Higginsville, MO 64037

    Contact for pricing

    Maintenance-free exterior with central heating and A/C in a multi-use office and retail space listing.

    View details
    Odessa Mixed-Use Building For Sale
    Odessa Mixed-Use Building For Sale

    1232 Old U.S. 40, Odessa, MO 64076

    Contact for pricing
    23,000 sqft

    23,000 SF building suitable for retail, office, or industrial.

    View details
    Odessa Office Building For Sale
    Odessa Office Building For Sale

    316 W. Old 40 Highway, Odessa, MO 64076

    Contact for pricing
    11,000 sqft

    Office building available for purchase in Odessa, Missouri.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Joplin Commercial Land For Lease
    Joplin Commercial Land For Lease

    2914&2920 E 22nd Street, Joplin, MO 64804

    $20 SF/Yr
    5,000 sqft

    Versatile commercial land with potential for customized building.

    View details
    Waukee Pad Site For Lease
    Waukee Pad Site For Lease

    405 E Hickman Rd, Waukee, IA 50263

    Contact for pricing

    1.1-acre pad site available for ground lease or build-to-suit.

    View details
    Office Units with Modern Build-Out
    Office Units with Modern Build-Out

    1902 Vandalia Street, Collinsville, IL 62234

    $5,000/Mo

    Recently built office space with private offices, an open bullpen, and an accessible ramp approach for entry.

    View details
    Office Development Land For Lease
    Office Development Land For Lease

    1323 Strawfloor Drive, Jonesboro, AR 72401

    Contact for pricing
    4,000 sqft

    2.43 acres for office development with build-to-suit opportunity.

    View details

    Lafayette County, MO Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in Lafayette County, MO with 1 listings featured on our commercial real estate exchange. The current inventory includes 1,750 square feet of properties.
    List
    Map

    Browse Office Spaces for Lease Near Lafayette, MO

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!