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    Independence, MO Office Properties & Spaces for Lease

    16 results
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    Office Spaces Available in 2025
    $13 SF/Yr
    1,237 SF

    Office Spaces Available in 2025

    3675 S Noland Rd, Independence, MO

    Office spaces for rent with ample parking and updates.

    • Excellent Interstate 70 access
    • Abundant on‑site parking
    • New ownership updating interiors with HVAC, thermostats, paint, flooring, and LED lights
    • Traffic counts over 20,000 cars per day
    • 740 SF and 3,004 SF office spaces available
    Updated: Sep 8, 2025
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    Retail/Medical Space on Highway 40
    Contact for pricing
    1,600 SF

    Retail/Medical Space on Highway 40

    17000 E US Hwy 40, Independence, MO

    Retail or medical spaces available for lease on Highway 40.

    • Located less than 1‑mile from Hwy 291/I‑470 Interchange.
    • Ample Parking: 3.7/1000 SF.
    • 1,600 - 5,372 SF available for lease.
    • Ideal for medical, special use, or retail users.
    • Under new ownership.
    Updated: Nov 4, 2025
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    Office Space Near I-70/I-470
    Contact for pricing
    2,616 SF

    Office Space Near I-70/I-470

    Centrally located office space with good highway visibility.

    4721-4731 S Cliff Ave, Independence, MO
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    Retail Endcap Space Available
    Contact for pricing
    3,150 SF

    Retail Endcap Space Available

    3,150 SF endcap space near major retailers.

    18931 E Valley View Pkwy, Independence, MO 64055
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    Built-Out Office Space Available
    $14 SF/Yr
    1,650 SF

    Built-Out Office Space Available

    Office space with private offices, restroom, and reception area.

    19401 Us-40 E, Independence, MO 64055
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    Medical Office Space Available
    $1,900 /Mo
    1,200 SF

    Medical Office Space Available

    2700 SF medical office with multiple exam/office rooms.

    3800 S Elizabeth St, Independence, MO
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    Medical Office Space For Rent
    Contact for pricing
    5,276 SF

    Medical Office Space For Rent

    Medical office space with hospital access and ample parking.

    19550-19600 E 39th St S, Independence, MO
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    Renovated Office Space Available
    $12 SF/Yr
    7,575 SF

    Renovated Office Space Available

    3,000-7,575 SF office space for lease after 2021 renovations.

    201 E Partridge Ave, Independence, MO
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    Office Space with Private Restroom
    $10 SF/Yr
    1,361 SF

    Office Space with Private Restroom

    Office space featuring private offices, restroom, and designated storage.

    14405 E 42nd St S, Independence, MO
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    Highway Frontage Office/Retail Space
    Contact for pricing
    5,952 SF

    Highway Frontage Office/Retail Space

    2,712 sq ft office/retail space with highway frontage.

    13801 E US Hwy 40, Independence, MO 64055
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    Renovated Office Space Available
    Contact for pricing

    Renovated Office Space Available

    Newly renovated office space with conference room and cubicles.

    13801A E US Hwy 40, Independence, MO 64055
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    Scottsdale Center Retail Opportunity
    Contact for pricing
    4,800 SF

    Scottsdale Center Retail Opportunity

    Retail space available in Scottsdale Center, Independence, Missouri.

    17020 E US Hwy 40, Independence, MO 64055
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    Office Building with Private Suites
    Contact for pricing
    10,195 SF

    Office Building with Private Suites

    Office building featuring private suites and restrooms available for lease.

    14401 E 42nd St S, Independence, MO 64055
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    Office Space for Lease
    Contact for pricing

    Office Space for Lease

    Office space available for lease in Independence, Missouri.

    4911 S Arrowhead Dr, Independence, MO 64055
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    Prime Location in Independence, Missouri
    Contact for pricing

    Prime Location in Independence, Missouri

    Strategically located at the crossroads of I-70 and I-470.

    18777 East 39th St S, Independence, MO 64057
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    Retail Spaces Available For Rent
    Contact for pricing
    1,400 SF

    Retail Spaces Available For Rent

    Retail spaces available, ranging from 1,200 to 1,400 SqFt.

    3600 S Noland Rd, Independence, MO 64055
    View details
    Based on your search, we've compiled 40 Potential Opportunities for your consideration. Besides 16 Active listings in Independence, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 16 Properties for Sales.

    Explore Office properties & Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Medical Office Space For Lease
    $25 SF/Yr
    6,560 SF

    Medical Office Space For Lease

    Class B medical office building with attractive clinic setting.

    3601 NE Ralph Powell Rd, Lees Summit, MO
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    Retail Space in Blue Vue
    Contact for pricing

    Retail Space in Blue Vue

    Retail space available in Blue Vue neighborhood center.

    Kansas City, MO 64133
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    Office Space in Kansas City
    Contact for pricing
    13,900 SF

    Office Space in Kansas City

    13,900 sq ft office space available for rent.

    12019 E 47th St, Kansas City, MO
    View details
    Medical Office Space Available
    Contact for pricing
    4,350 SF

    Medical Office Space Available

    Class A medical office space for lease with exam rooms.

    Lees Summit, MO 64064
    View details

    Explore Similar Spaces for Sale in Independence, MO

    Consider Similar Space for Sale. We found 16 Spaces matching your search parameters.

    Remodeled Commercial Space on High-Traffic Street
    $250,000
    0.20 Acres

    Remodeled Commercial Space on High-Traffic Street

    Affordable, remodeled commercial space with high visibility on 23rd Street.

    307 E 23rd Street, Independence, MO 64055
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    Independence Office Building For Sale
    $3,100,000
    1.60 Acres

    Independence Office Building For Sale

    Office building with freeway visibility and strong retail anchors.

    20101 E JACKSON Drive, Independence, MO 64057
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    Commercial Building with Nine Units
    $475,000
    0.43 Acres

    Commercial Building with Nine Units

    Commercial building with nine units on a busy corner.

    3501 S Sterling Avenue, Independence, MO 64052
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    Downtown Independence Commercial Building For Sale
    $1,300,000
    0.30 Acres

    Downtown Independence Commercial Building For Sale

    Well-maintained commercial building in Downtown Independence, suitable for various uses.

    120 S Liberty Street, Independence, MO 64050
    View details
    SINGLE_FAMILY - Independence, MO
    $730,000
    0.77 Acres

    SINGLE_FAMILY - Independence, MO

    Retail space · 0.77 Acres

    4541 S Noland Road, Independence, MO 64055
    View details
    Remodeled Office Building For Sale
    $950,000
    14,882 SF

    Remodeled Office Building For Sale

    Remodeled office building with highway access in Independence, Missouri.

    13720 E 42nd Ter S, Independence, MO
    View details
    Multi-Tenant Retail/Office Building For Sale
    $155,000
    2,184 SF

    Multi-Tenant Retail/Office Building For Sale

    2,184 SF multi-tenant retail/office building on 8,757 SF lot.

    3305 Blue Ridge Cutoff, Independence, MO 64055
    View details
    Independence Commercial Building For Sale
    $365,000
    0.28 Acres

    Independence Commercial Building For Sale

    3,456 SF commercial building in high-traffic area.

    13717 E 39th Street, Independence, MO 64055
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land For Rent
    Contact for pricing

    Commercial Land For Rent

    Commercial land available for rent with high traffic volume.

    14231 E US Hwy 40, Kansas City, MO
    View details
    Fenced Land for Lease
    $0.72 SF/Yr

    Fenced Land for Lease

    2.0 +/- acres of fenced outside storage for lease.

    Kansas City, MO 64133
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    Land in Independence Business District
    Contact for pricing

    Land in Independence Business District

    Land available for lease in established Independence, MO area.

    18901 East Us Highway 24, Independence, MO 64056
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    Prime Commercial Land for Lease
    $10,833 /Mo

    Prime Commercial Land for Lease

    Commercial land available for lease with high-traffic location.

    Lees Summit, MO
    View details

    Independence, MO Office properties & Spaces Leasing Opportunities Market Analysis

    Explore Office properties & Spaces leasing options in Independence, MO with 16 listings featured on our commercial real estate exchange. The current inventory includes 52,272,000 square feet of properties with an estimated lease value of $19 SF/Yr.

    Estimated lease rates for Office properties & Spaces in Independence, MO begin at $19 SF/Yr, with an average of $19 SF/Yr and extend to $19 SF/Yr.
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    Most Searched ZIP Codes in Independence, MO

    • 64055
    • 64057

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