Lewes, DE Office Properties & Spaces for Rent & Lease

$23 SF/Yr

46,609 SF

Versatile Lewes Office Space

16529 N Coastal Hwy, Lewes, DE 19958

Professional office space ideal for medical or executive use.

Versatile layout ideal for medical, executive, or professional office use, featuring multiple private offices/exam rooms and flexible workspaces.
Excellent front‑facing visibility and convenient client access.
Strategically positioned near major healthcare destinations.
Opportunity to customize the layout based on operational needs.
Two potential reception areas at the main front entrance and a large lobby.

Updated: Feb 23

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$23 SF/Yr

46,609 SF

Versatile Professional Space in Lewes

16529 N Coastal Hwy, Lewes, DE 19958

Prime medical or executive office space with customizable layout.

Prime professional space ideal for medical, executive, or other professional use.
Versatile layout featuring multiple private offices/exam rooms and flexible workspaces.
Excellent front‑facing visibility and convenient client access.
Strategically positioned near major healthcare destinations.
Opportunity to customize the layout based on operational needs.

Updated: Feb 23

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$23 SF/Yr

46,609 SF

Versatile Executive Office Space

Professional office space ideal for medical, executive, or professional use.

16529 N Coastal Hwy, Lewes, DE 19958

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$23 SF/Yr

46,609 SF

Lewes, DE Professional Office Space

Versatile medical or executive office space in Lewes, Delaware.

16529 N Coastal Hwy, Lewes, DE 19958

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$20 SF/Yr

Lewes Office/Flex Space Available

Professional office/flex space in Lewes, DE, ideal for various uses.

32191 Nassau Rd, Lewes, DE 19958

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$6,000 / Mo

21,344 SF

Lewes Office Space For Lease

3,200 SF office building in desirable Nassau Commons location.

17503 Nassau Cmns Blvd, Lewes, DE 19958

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$4,000 / Mo

21,344 SF

Spacious Commercial Space in Lewes

Large commercial space with parking and flexible usage options available.

17569 Nassau Cmns Blvd, Lewes, DE 19958

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$575 / Mo

Professional Office Suite For Lease

Single-room office suite in Lewes, DE, includes CAM and utilities.

17527 Nassau Cmns Blvd, Lewes, DE 19958

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$525 / Mo

Single-Room Office Suite in Lewes

First-floor office suite with shared amenities in a prime location.

17527 Nassau Cmns Blvd, Lewes, DE 19958

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$3,000 / Mo

Route 1 Commercial Space Available

Prime commercial space on Route 1, available immediately.

18354 Coastal Hwy, Lewes, DE 19958

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$1,500 / Mo

Office Space in Nassau Commons

Office space available for lease starting October 1, 2025.

17577 Nassau Commons Blvd, Lewes, DE 19958

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$25 SF/Yr

6,340 SF

Lewes Office Building on Highway

Professional office building with direct highway frontage in Lewes, DE.

18344 Coastal Hwy, Lewes, DE 19958

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$30 SF/Yr

New Retail/Office Pad Sites

Two new construction pad sites in a vibrant community.

Zinfandel Ln, Lewes, DE 19958

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$4,000 / Mo

Spacious Commercial Space Available

Large commercial space with office, shop, and parking areas.

17569 Nassau Commons Blvd, Lewes, DE 19958

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Based on your search, we've compiled 22 Potential Opportunities for your consideration. Besides 14 Active listings in Lewes, DE, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 4 Properties for Sales.

Explore Office Properties & Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

$23 SF/Yr

Professional Office Space For Rent

Second-floor office space with existing fit-out near medical facilities.

19405 Plantations Rd, Rehoboth Beach, DE 19971

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$32 SF/Yr

Office Space For Rent

Office space available for lease.

19791 Coastal Hwy, Rehoboth Beach, DE 19971

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$22 SF/Yr

4,200 SF

Prime Milton Medical Office Space

4,200 SF Medical Office - Available Now

616 Mulberry St, Milton, DE 19968

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$18 SF/Yr

Prime Commercial Space For Rent

4,200 SF commercial space ideal for office, retail, or medical.

612 Mulberry St, Milton, DE 19968

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Explore Similar Spaces for Sale in Lewes, DE

Consider Similar Space for Sale. We found 4 Spaces in Nearby Locations matching your search parameters.

$499,000

900 SF

Lewes Office Space: Prime Location

Beachfront Office, Income Producing, Updated

110 Anglers Rd, Lewes, DE 19958

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$2,200,000

3,200 SF

Lewes Office Building - High ROI

Prime Lewes location, high rental income, recent upgrades.

1546 Savannah Rd, Lewes, DE 19958

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Contact for pricing

1.64 Acres

Coastal Highway Office Space Available

New Lewes Office, High Traffic Area

18422 Coastal Hwy, Lewes, DE 19958

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Lewes Office Building - Investment Opportunity

$1,400,000

2,600 SF

Lewes Office Building - Investment Opportunity

Prime Lewes location, 2600 sq ft office, 0.49 acre lot.

17493 Nassau Cmns Blvd, Lewes, DE 19958

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Lewes, DE Office Properties & Spaces Leasing Opportunities Market Analysis

Explore Office Properties & Spaces leasing options in Lewes, DE with 18 listings featured on our commercial real estate exchange. The current inventory includes 10,256,881,434 square feet of properties with an estimated lease value of $122 SF/Yr.

Estimated lease rates for Office Properties & Spaces in Lewes, DE begin at $2 SF/Yr, with an average of $17 SF/Yr and extend to $25 SF/Yr.

Lewes, DE Office Properties & Spaces for Lease

Versatile Lewes Office Space

Professional office space ideal for medical or executive use.

Versatile Professional Space in Lewes

Prime medical or executive office space with customizable layout.

Versatile Executive Office Space

Lewes, DE Professional Office Space

Lewes Office/Flex Space Available

Lewes Office Space For Lease

Spacious Commercial Space in Lewes

Professional Office Suite For Lease

Single-Room Office Suite in Lewes

Route 1 Commercial Space Available

Office Space in Nassau Commons

Lewes Office Building on Highway

New Retail/Office Pad Sites

Spacious Commercial Space Available

Explore Office Properties & Spaces for Lease in Nearby Cities

Professional Office Space For Rent

Office Space For Rent

Prime Milton Medical Office Space

Prime Commercial Space For Rent

Explore Similar Spaces for Sale in Lewes, DE

Lewes Office Space: Prime Location

Lewes Office Building - High ROI

Coastal Highway Office Space Available

Lewes Office Building - Investment Opportunity

Lewes, DE Office Properties & Spaces Leasing Opportunities Market Analysis

Browse Office Properties & Spaces for Lease Near Lewes, DE

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Lewes, DE Office Properties & Spaces for Lease

Versatile Lewes Office Space

Professional office space ideal for medical or executive use.

Versatile Professional Space in Lewes

Prime medical or executive office space with customizable layout.

Versatile Executive Office Space

Lewes, DE Professional Office Space

Lewes Office/Flex Space Available

Lewes Office Space For Lease

Spacious Commercial Space in Lewes

Professional Office Suite For Lease

Single-Room Office Suite in Lewes

Route 1 Commercial Space Available

Office Space in Nassau Commons

Lewes Office Building on Highway

New Retail/Office Pad Sites

Spacious Commercial Space Available

Explore Office Properties & Spaces for Lease in Nearby Cities

Professional Office Space For Rent

Office Space For Rent

Prime Milton Medical Office Space

Prime Commercial Space For Rent

Explore Similar Spaces for Sale in Lewes, DE

Lewes Office Space: Prime Location

Lewes Office Building - High ROI

Coastal Highway Office Space Available

Lewes Office Building - Investment Opportunity

Lewes, DE Office Properties & Spaces Leasing Opportunities Market Analysis

Browse Office Properties & Spaces for Lease Near Lewes, DE

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