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    Lewes, DE Commercial Real Estate for Lease

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    Newark, DE New Castle, DE Dover, DE
    14 results
    Versatile Lewes Office Space
    $23 SF/Yr

    Versatile Lewes Office Space

    16529 N COASTAL Highway, Lewes, DE 19958

    Professional office space ideal for medical or executive use.

    • Versatile layout ideal for medical, executive, or professional office use, featuring multiple private offices/exam rooms and flexible workspaces.
    • Excellent front‑facing visibility and convenient client access.
    • Strategically positioned near major healthcare destinations.
    • Opportunity to customize the layout based on operational needs.
    • Two potential reception areas at the main front entrance and a large lobby.
    Updated: Feb 23
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    Lewes Office Space For Lease
    $6,000 /Mo

    Lewes Office Space For Lease

    17503 NASSAU COMMONS Boulevard, Lewes, DE 19958

    3,200 SF office space in desirable Nassau Commons.

    • Located in the highly desirable Nassau Commons commercial corridor near Coastal Highway and Lewes‑Georgetown Highway.
    • 3,200‑square‑foot building suitable for a variety of commercial uses.
    • Features a reception area, kitchen, five offices, storage area, two bathrooms, and mechanical room.
    • Adjacent to Redner's grocery store and the bike trail.
    • Exterior features include landscaping, covered porch, and patio.
    Updated: Apr 17
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    Versatile Lewes Commercial Flex Space
    $22 SF/Yr

    Versatile Lewes Commercial Flex Space

    Adaptable 1,962 SF space suitable for various business types.

    32191 NASSAU Road, Lewes, DE 19958
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    Lewes Office/Flex Space Available
    $20 SF/Yr

    Lewes Office/Flex Space Available

    Professional office/flex space in Lewes, DE, ideal for various uses.

    32191 NASSAU Road, Lewes, DE 19958
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    Single-Room Office Suite in Lewes
    $575 /Mo

    Single-Room Office Suite in Lewes

    Second-floor office suite with shared amenities, utilities included.

    17527 NASSAU COMMONS Boulevard, Lewes, DE 19958
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    Retail Space in Nassau Commons
    $575 /Mo

    Retail Space in Nassau Commons

    Retail space available for rent in Lewes, Delaware.

    17527 Nassau Commons Blvd #209, Lewes, DE 19958
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    Retail Space in Nassau Commons
    $525 /Mo

    Retail Space in Nassau Commons

    Retail space available for rent in Lewes, Delaware.

    17527 Nassau Commons Blvd #113, Lewes, DE 19958
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    Retail Space For Rent
    $1,500 /Mo

    Retail Space For Rent

    Retail space available for rent in Lewes, Delaware.

    17577 Nassau Commons Blvd #206, Lewes, DE 19958
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    New Retail/Office Pad Sites
    $30 SF/Yr

    New Retail/Office Pad Sites

    Two new construction pad sites in a vibrant community.

    Zinfandel Lane, Lewes, DE 19958
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    Retail Space For Rent
    $6,000 /Mo

    Retail Space For Rent

    Retail space available for lease in Lewes, Delaware.

    17503 Nassau Commons Blvd, Lewes, DE 19958
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    Retail Space in Nassau Commons
    $4,000 /Mo

    Retail Space in Nassau Commons

    Retail space for rent in Lewes, Delaware.

    17569 Nassau Commons Blvd, Lewes, DE 19958
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    Coastal Highway Commercial Opportunity
    Contact for pricing

    Coastal Highway Commercial Opportunity

    Prime commercial parcel on Coastal Highway, available February 2026.

    18355 Coastal Hwy, Lewes, DE 19958
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    Lewes Office Building on Highway
    $25 SF/Yr
    6,340 SF

    Lewes Office Building on Highway

    Professional office building with direct highway frontage in Lewes, DE.

    18344 Coastal Hwy, Lewes, DE
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    Customizable Warehouse Space For Lease
    Contact for pricing
    3,500 SF

    Customizable Warehouse Space For Lease

    Flexible warehouse space available on Coastal Highway in Lewes, DE.

    16727 Coastal Hwy, Lewes, DE 19958
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    Based on your search, we've compiled 25 Potential Opportunities for your consideration. Besides 14 Active listings in Lewes, DE, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 7 Properties for Sales.

    Explore Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Coastal Highway Commercial Property Rental
    $2,500 /Mo

    Coastal Highway Commercial Property Rental

    Commercial property available for rent on Coastal Highway.

    30616, 30620 & 30627 Coastal Hwy, Milton, DE 19968
    View details
    Rehoboth Beach Office Space Available
    $23 SF/Yr

    Rehoboth Beach Office Space Available

    Office unit for rent, located off Route 24.

    19405 Plantations Road #2, Rehoboth Beach, DE 19971
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    Renovated Flex Space on Coastal
    Contact for pricing
    1,200 SF

    Renovated Flex Space on Coastal

    Newly renovated warehouse spaces available for lease on Coastal Highway.

    30620 Coastal Hwy, Milton, DE 19968
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    Rehoboth Beach Retail Space Available
    Contact for pricing
    10,125 SF

    Rehoboth Beach Retail Space Available

    Retail space for lease in Rehoboth Beach, Delaware.

    18914 Rehoboth Mall Blvd, Rehoboth Beach, DE
    View details

    Explore Similar Spaces for Sale in Lewes, DE

    Consider Similar Space for Sale. We found 7 Spaces matching your search parameters.

    Lewes Land For Sale
    $500,000
    0.11 Acres

    Lewes Land For Sale

    50x100 lot in the heart of Lewes, Delaware.

    N MULBERRY Street lot: 3, Lewes, DE 19958
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    Commercial Property with Residential Structure
    $975,000
    0.51 Acres

    Commercial Property with Residential Structure

    Half-acre commercial property with existing home and business potential.

    17548 SHADY ROAD, Lewes, DE 19958
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    Versatile Commercial Space For Sale
    Contact for pricing
    1,962 SF

    Versatile Commercial Space For Sale

    Adaptable 1,962 SF commercial space, ideal for various businesses.

    32191 Nassau Road, Lewes, DE 19958
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    Lewes Office Building on Coastal Highway
    Contact for pricing
    6,340 SF

    Lewes Office Building on Coastal Highway

    Professional office building with highway frontage and high visibility.

    18334 Coastal Highway, Lewes, DE 19958
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    Office/Flex Space For Sale
    Contact for pricing

    Office/Flex Space For Sale

    Professional office/flex space ideal for design, consulting, or fitness.

    32191 Nassau Road 2, Lewes, DE 19958
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    Lewes Harbor Canal Front Lot
    $1,975,000

    Lewes Harbor Canal Front Lot

    Premier canal front lot with deeded boat slips.

    201 Anglers Road, Lewes, DE 19958
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    Commercial Pad Sites For Sale
    Contact for pricing

    Commercial Pad Sites For Sale

    Two pad sites suitable for retail, restaurant, office, or medical.

    Zinfandel Lane, Lewes, DE 19958
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    Lewes, DE Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Lewes, DE with 14 listings featured on our commercial real estate exchange. The current inventory includes 2,306,467,118 square feet of properties with an estimated lease value of $48 SF/Yr.

    Estimated lease rates for Commercial real estate in Lewes, DE begin at $23 SF/Yr, with an average of $24 SF/Yr and extend to $25 SF/Yr.
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