Durham, CT Office Spaces for Rent & Lease

Updated: Jul 29

Office Space with Optional Build-Outs

350 Main Street Building 354, Durham, CT 06422

$1,000/Mo

900 sqft

Approximately 900 SF office space with one bathroom
Optional build‑outs available to customize the space
Central Durham Center location along Main Street
BikeScore 33 (Somewhat Bikeable)
walkScore 42 (Car‑Dependent)

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Updated: Aug 1, 2025

Versatile Commercial Space in Durham

350 Main Street #1, Durham, CT 06422

$5,000/Mo

5,000 sqft

Prime location in the heart of Durham Center with high visibility and convenient Main Street access.
Flexible space options: 5,000 sq ft or two separate 2,500 sq ft bays.
Customizable build‑outs available to meet specific business needs.
Suitable for a variety of businesses including studio, office, or creative workspace.
Open layout with bright interior.

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Industrial Flex Space For Rent

42 Ozick Dr, Durham, CT

Contact for pricing

3,400 sqft 4.61 AC lot

3,400± SF industrial flex space with office and warehouse.

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Former Bank Building for Lease

376 Main St, Durham, CT 06422

Contact for pricing

3,328 sqft

Office/retail space in a former bank building.

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Based on your search, we've compiled 9 Potential Opportunities for your consideration. Besides 4 Active listings in Durham, CT, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 1 Properties for Sales.

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Wallingford Office/Flex Space For Rent

900 Northrop Road, Wallingford, CT 06492

$10.50 SF/Yr

11,725 sqft

Office/flex space available in Wallingford, CT with convenient highway access.

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Furnished Office Suites

145 Broad Street, #LL1 & LL2, Middletown, CT 06457

$1,750/Mo

800 sqft

Flexible workspace includes private offices, reception space, and conference furnishings for professional use.

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Middletown Office Space For Lease

440 Middlefield Street, Middletown, CT

Contact for pricing

6,250 sqft 5.32 AC lot

6,250 SF office space available in Middletown, Connecticut.

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Sublease Office Space

10 Research Pkwy, Wallingford, CT 06492

Contact for pricing

24,264 sqft

Sublease office space available at 10 Research Pkwy with 10,000 to 24,264 SF for flexible occupancy.

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Similar Spaces for Sale in Durham, CT

Consider Similar Space for Sale. We found 1 Spaces matching your search parameters.

Office Property

370 MAIN ST, Durham, CT 06422

Contact for pricing

4,678 sqft

Office space is available through either a sale or lease transaction.

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Durham, CT Office Spaces Lease Rates & Market Statistics

Explore 4 Office Spaces for lease in Durham, CT on Realmo, a commercial real estate exchange covering the Durham area. The current inventory totals 12,628 square feet of properties.

Asking lease rates for Office Spaces in Durham start at $12 SF/Yr, average $12.66 SF/Yr, and reach $13.33 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $12.66 SF/Yr is 40% below the Connecticut state average of $21.13 SF/Yr.

Durham accounts for 3% of the 150 office spaces currently available across Middlesex County, where nearby markets include Middletown and Old Saybrook.