Durham, CT Office Spaces for Rent & Lease

Updated: Apr 22

Durham Commercial Space on Main

350 Main Street #Building 354, Durham, CT 06422

$1,100/Mo

900 sqft

High‑traffic, central Main Street location in Durham Center offering excellent visibility.
Flexible 900 sq ft commercial space suitable for retail, office, studio, or creative workspace.
Customizable layout with optional build‑outs available.
Convenient access on Main Street.
Affordable lease at $1,100 per month plus utilities.

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Updated: Nov 24, 2025

Industrial Flex Space For Rent

42 Ozick Dr, Durham, CT

$9 SF/Yr

3,400 sqft

3,400± SF Industrial Flex Space
1,700± SF Office – Main Floor
1,700± SF – Warehouse – Lower Level
16' Ceiling Height in Warehouse
Electric Service: 480 v / 400 amps

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Versatile Commercial Space in Durham

350 Main Street #1, Durham, CT 06422

$5,000/Mo

5,000 sqft

Flexible commercial space in Durham Center, ideal for various businesses.

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Former Bank Building Office/Retail Space

376 Main St, Durham, CT

$20 SF/Yr

3,328 sqft

Office/retail space in a former bank building with parking.

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Based on your search, we've compiled 14 Potential Opportunities for your consideration. Besides 4 Active listings in Durham, CT, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 2 Properties for Sales.

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Professional Office Suite with Parking

1501 E Main Street, Meriden, CT 06450

$20 SF/Yr

1,400 sqft

Well-maintained office suite features three individual offices and ample on-site parking for convenient access.

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Professional Office Suite For Rent

1501 E Main St, Meriden, CT 06450

$20 SF/Yr

1,400 sqft

Modern 1,400 sq ft office suite with three individual offices.

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Wallingford Office/Flex Space For Rent

900 Northrop Road, Wallingford, CT 06492

$10.50 SF/Yr

11,725 sqft

Office/flex space available in Wallingford, CT with convenient highway access.

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Class A Office Building

35 Thorpe Ave, Wallingford, CT

$22.50 SF/Yr

6,637 sqft

83,654 SF Class A office building with highway access.

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Similar Spaces for Sale in Durham, CT

Consider Similar Space for Sale. We found 2 Spaces matching your search parameters.

Freestanding Commercial Building

980 New Haven Road, Durham, CT 06422

$1,300,000

2,256 sqft 2.30 AC lot

Freestanding building on Route 17 in Durham, currently under renovation with flexible space and ample on-site parking.

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Heavy Industrial Manufacturing Building

18 Airline Road, Durham, CT 06422

$700,000

14,210 sqft 2.20 AC lot

Block and steel industrial building with 14–16-foot ceilings, 1,000 SF office, and 1,600-amp 3-phase power on 2.2 acres.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Commercial Land on Montauk Highway

1467 Montauk Highway, Mastic, NY 11967

$2,500/Mo

0.55-acre commercial lot on busy Montauk Highway.

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Prime Land for Ground Lease

Shirley, NY 11967

Contact for pricing

20,245 sq ft land in high-traffic retail corridor.

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Prime Retail Corridor Land Lease

550 William Floyd Pkwy, Shirley, NY 11967

$10,000/Mo

20,245 sq ft land for lease in Shirley, NY.

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Commercial Land in High-Traffic Area

586 Montauk Highway, Shirley, NY 11967

$1,000/Mo

0.18 acre vacant lot with high visibility and traffic.

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Durham, CT Office Spaces Market Trends and Statistics

Explore Office Spaces leasing options in Durham, CT with 4 listings featured on our commercial real estate exchange. The current inventory includes 12,628 square feet of properties with an estimated lease value of $55.67 SF/Yr.

Estimated lease rates for Office Spaces in Durham, CT begin at $9 SF/Yr, with an average of $13.92 SF/Yr and extend to $20 SF/Yr.