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    Palmdale, CA
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    Palmdale, CA Office Spaces for Lease

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    Lancaster, CA Agua Dulce, CA Santa Clarita, CA
    12 results
    Palmdale Office Space For Rent
    $550/Mo
    1,100 SF
    Palmdale Office Space For Rent

    533 E Palmdale Boulevard, Palmdale, CA 93550

    Office space for rent in Palmdale shopping center.
    • Storefront desk space in a well‑established shopping center.
    • Prime location on Palmdale Blvd.
    • Suitable for Real Estate, Real Estate Loans, Insurance, Legal Desk, Immigration, etc.
    • Central heating (Natural Gas) and Central Air cooling.
    • Concrete construction.
    Updated: Aug 15, 2025
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    Move-In Ready Palmdale Office Space
    $1.00 SF/Yr
    2,072 SF
    Move-In Ready Palmdale Office Space

    4621 S Avenue, Palmdale, CA 93552

    Multiple suites available in Palmdale, CA, ready for occupancy.
    • Move‑in ready office space.
    • Multiple vacant suites available.
    • Variety of suite sizes available, from 1,400sf to 21,500sf.
    • Former Realty office.
    • Includes bullpen, offices, and restroom.
    Updated: Mar 27
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    SIERRA HIGHWAY BUSINESS PLAZA FOR OFFICES, FLEX
    $1.00 SF/Yr
    SIERRA HIGHWAY BUSINESS PLAZA FOR OFFICES, FLEX

    Sierra Highway Plaza

    190 Sierra Ct, Palmdale, CA 93550

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    Office Space in Palmdale Center
    $450/Mo
    1,000 SF
    Office Space in Palmdale Center

    Desk for rent in Palmdale shopping center, internet included.

    533 E Palmdale Boulevard, Palmdale, CA 93550

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    Palmdale Medical Office Space
    $2.00 SF/Yr
    10,000 SF
    Palmdale Medical Office Space

    New medical office space for lease in Palmdale, CA.

    635 Commerce Avenue, Palmdale, CA 93551

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    Palmdale Office Building For Lease
    Contact for pricing
    2,755 SF
    Palmdale Office Building For Lease

    Office building with 2,755 SF available for lease.

    847 Auto Center Dr, Palmdale, CA 93551

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    Medical Office Space Available
    Contact for pricing
    Medical Office Space Available

    New medical office building in Antelope Valley, Los Angeles.

    42155 11th Street West, Palmdale, CA 93551

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    Palmdale Office Space Available
    Contact for pricing
    59,577 SF
    Palmdale Office Space Available

    Office suites available for lease in Palmdale, California.

    38660 Medical Center Dr., Palmdale, CA 93551

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    Commercial Space in Palmdale, CA
    $22 SF/Yr
    Commercial Space in Palmdale, CA

    Commercial space available in growing Palmdale, Los Angeles County.

    520 - 540 Palmdale, Palmdale, CA 93551

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    Palmdale Office Suite For Rent
    $2.00 SF/Yr
    1,400 SF
    Palmdale Office Suite For Rent

    Move-in ready office suite in Palmdale Business Park.

    38700 W 5th Street, Palmdale, CA 93551

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    Move-in Ready Office Suite
    $1.50 SF/Yr
    1,400 SF
    Move-in Ready Office Suite

    Professional office suite for rent in Palmdale Business Park.

    38700 W 5th Street E, Palmdale, CA 93551

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    Suburban Office Complex For Rent
    Contact for pricing
    Suburban Office Complex For Rent

    Two-story office complex with modern glass façade and landscaping.

    39959 Sierra Hwy, Palmdale, CA 93550

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    Based on your search, we've compiled 33 Potential Opportunities for your consideration. Besides 12 Active listings in Palmdale, CA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 13 Properties for Sales.

    Office Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Lancaster Commercial Flex Space Available
    $1.00 SF/Yr
    5,000 SF
    Lancaster Commercial Flex Space Available

    Flex space with shop and office, convenient freeway access.

    42425 E 5th Street, Lancaster, CA 93535

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    Lancaster Office/Flex Space Available
    $2.00 SF/Yr
    3,298 SF
    Lancaster Office/Flex Space Available

    Move-in ready office with roll-up door in Lancaster Business Park.

    42913 Capital Drive, Lancaster, CA 93535

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    Move-In Ready Office Space
    $1.25 SF/Yr
    Move-In Ready Office Space

    Office space featuring a lobby, reception area, and private offices.

    42311 10th St W, Lancaster, CA 93534

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    Freestanding Building in Mid-Cities Location
    Contact for pricing
    6,500 SF
    Freestanding Building in Mid-Cities Location

    Freestanding building with convenient freeway access and modern amenities.

    42142 7th St W, Lancaster, CA 93534

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    Similar Spaces for Sale in Palmdale, CA

    Consider Similar Space for Sale. We found 13 Spaces matching your search parameters.

    Versatile Palmdale Live/Work Property
    $595,000
    700 SF
    Versatile Palmdale Live/Work Property

    4.86 acre Palmdale property with live/work setup.

    38960 12th Street E, Palmdale, CA 93550

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    Palmdale Land with Development Potential
    $180,000
    1.00 Acre
    Palmdale Land with Development Potential

    Two adjacent parcels totaling 43,449 sq ft in Palmdale, CA.

    Sierra Highway, Palmdale, CA 93550

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    Palmdale Commercial Investment Opportunity
    $1,449,900
    13,100 SF
    Palmdale Commercial Investment Opportunity

    Three office buildings on one lot near Downtown Palmdale.

    1309 E Palmdale Boulevard, Palmdale, CA 93550

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    Palmdale Mixed-Use Investment Opportunity
    $567,000
    3,228 SF
    Palmdale Mixed-Use Investment Opportunity

    Mixed-use property with income potential in a prime location.

    38262 6th E, Palmdale, CA 93550

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    Versatile Live/Work Property in Palmdale
    $595,000
    4.86 Acres
    Versatile Live/Work Property in Palmdale

    Rare 4.86-acre live/work property with business potential.

    38960 12th Street E, Palmdale, CA 93550

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    Office/Warehouse Condo in Palmdale
    $435,000
    2,427 SF
    Office/Warehouse Condo in Palmdale

    2,430 SF office/warehouse condo in excellent condition, built in 2007.

    650 Commerce Avenue, Unit D, Palmdale, CA 93551

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    Medical Office Investment Opportunity
    $3,950,000
    13,200 SF
    Medical Office Investment Opportunity

    Two buildings near Palmdale Regional Medical Center for sale.

    450 W Palmdale, Palmdale, CA 93551

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    Palmdale Freestanding Office Building
    $1,100,000
    5,518 SF
    Palmdale Freestanding Office Building

    Freestanding office building with frontage on Palmdale Boulevard.

    921 East Palmdale Boulevard, Palmdale, CA 93550

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    Palmdale Freestanding Commercial Building
    $989,000
    3,500 SF
    Palmdale Freestanding Commercial Building

    Well-maintained commercial building in Palmdale, ideal for owner-users or investors.

    38423 9th St E, Palmdale, CA 93550

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    New Class A Medical Office
    Contact for pricing
    24,600 SF
    New Class A Medical Office

    New 24,600 SF Class A medical office building.

    42155 11th Street West, Palmdale, CA 93551

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    Palmdale DaVita For Sale
    $6,442,755
    13,750 SF
    Palmdale DaVita For Sale

    DaVita with long-term lease in Palmdale, California.

    38454 5th St W, Palmdale, CA 93551

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    Former Mortuary in High Visibility
    $780,000
    4,401 SF
    Former Mortuary in High Visibility

    Versatile commercial property with high visibility and diverse potential uses.

    8837 E Palmdale Boulevard, Palmdale, CA 93552

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Fontana Commercial Land Lease
    $0.01 SF/Yr
    1,565 SF
    Prime Fontana Commercial Land Lease

    4.33-acre commercial land for ground lease in Fontana, CA.

    16203 Foothill Boulevard, Fontana, CA 92335

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    Service Commercial Land For Rent
    Contact for pricing
    Service Commercial Land For Rent

    3-acre service commercial land in high-traffic Hanford location.

    1798 Hanford Armona Road, Hanford, CA 93230

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    Prime Commercial Land for Lease
    Contact for pricing
    75,000 SF
    Prime Commercial Land for Lease

    Highly visible 3.59-acre commercial land in San Luis Obispo.

    2040 Prado Road, San Luis Obispo, CA 93401

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    High Visibility Land For Lease
    Contact for pricing
    High Visibility Land For Lease

    1.41 acres at signalized intersection available for ground lease.

    1400 Willow Pass Rd, Concord, CA 94520

    View details

    Palmdale, CA Office Spaces Leasing Opportunities Market Analysis

    Explore Office Spaces leasing options in Palmdale, CA with 12 listings featured on our commercial real estate exchange. The current inventory includes 17,372 square feet of properties with an estimated lease value of $18 SF/Yr.

    Estimated lease rates for Office Spaces in Palmdale, CA begin at $1.00 SF/Yr, with an average of $2 SF/Yr and extend to $6 SF/Yr.
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    Most Searched ZIP Codes in Palmdale, CA

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