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Los Altos, CA Office Spaces for Lease

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25 properties
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Expandable Office Unit
Updated: Aug 9
Expandable Office Unit

400 Main St, Suite 160, Los Altos, CA 94022

$3,386/Mo
3,386 sqft
3,386 SF office unit at 400 Main St, Suite 160
Suites 161, 200, and 250 may be combined
Combined configuration totals 24,832 SF
Available 04/01/27
Located in Los Altos, CA 94022
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Office Units with Suite Combination
Updated: Aug 9
Office Units with Suite Combination

400 Main St suite 200, Los Altos, CA 94022

$11,217/Mo
11,217 sqft
11,217 SF of office property area
Suites 161, 200, and 250 can be combined
Combined configuration totals 24,832 SF
Available beginning 04/01/27
Located at 400 Main St, Los Altos, CA 94022
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Office Units with Private Offices
Office Units with Private Offices

101-111 1st St, Los Altos, CA 94022

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3,299 sqft

Two-level office space combines open work areas, private offices, conference rooms, and abundant natural light.

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Improved Office Units
Improved Office Units

382 1st St, Los Altos, CA 94022

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4,200 sqft

Downtown office space includes upgraded interiors, monument signage, and on-site surface parking.

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Office Units with Conference Room
Office Units with Conference Room

400 Main St, Los Altos, CA 94022

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3,386 sqft

Professional workspace includes private offices, shared meeting space, and kitchen and breakroom amenities.

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Los Altos Office/Medical Space
Los Altos Office/Medical Space

1571 Carob Lane, Los Altos, CA 94024

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2,584 sqft

Office/Medical space for lease in Los Altos with on-site parking.

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Fully Furnished Office Units
Fully Furnished Office Units

4940 El Camino Real, Los Altos, CA 94022

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3,721 sqft

Office units available for lease can be delivered fully furnished, with future expansion potential on the second floor.

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Downtown Los Altos Office Space
Downtown Los Altos Office Space

300 Third Street, Los Altos, CA 94022

$5.25 SF/Yr

Office space available for lease in downtown Los Altos, CA.

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Office Space Available For Rent
Office Space Available For Rent

445 San Antonio Rd, S., #203, Los Altos, CA 94022

$61.80 SF/Yr

Office space for rent at 445 San Antonio Rd.

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Los Altos Office Space Available
Los Altos Office Space Available

108 1st Street, Los Altos, CA 94022

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4,257 sqft

Office space available for rent in Los Altos, California.

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Downtown Office Suite
Downtown Office Suite

334 STATE ST, Los Altos, CA 94022

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760 sqft

Office space measuring 760 SF is available for lease at 334 State St in Los Altos.

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Los Altos Office Space Available
Los Altos Office Space Available

300 San Antonio Road, Los Altos, CA 94022

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2,576 sqft

Office space available for lease in Los Altos, California.

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Medical Office Suite
Medical Office Suite

900 N San Antonio Rd, Los Altos, CA 94022

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950 sqft

Suite 100 offers approximately 950 square feet for medical uses, with two parking lots on site.

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Office Suite with Conference Room
Office Suite with Conference Room

4962 El Camino Real, Los Altos, CA 94022

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560 sqft

Office suite features an open layout with a glass conference room, kitchen/coffee bar, and natural light.

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Los Altos Office Space Available
Los Altos Office Space Available

4966 El Camino Real, Los Altos, CA

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1,310 sqft 0.43 AC lot

Open office space with natural light near amenities and transportation.

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Ambulatory Surgery Center
Ambulatory Surgery Center

4300 El Camino Real, Los Altos, CA 94022

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2,000 sqft

Ground-floor medical space with a private entrance, AAAHC accreditation, and a sublease term through 10/31/2028.

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Class A Office Space Available
Class A Office Space Available

779 Altos Oaks Drive, Los Altos, CA 94024

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3,643 sqft

Professional office space available for rent in Los Altos.

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Downtown Los Altos Office Space
Downtown Los Altos Office Space

167 S San Antonio Rd, Los Altos, CA

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7,227 sqft 0.84 AC lot

Class A office space with flexible configuration and parking.

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Office Units at Camino Altos
Office Units at Camino Altos

4300 El Camino Real, Suite 100, Los Altos, CA 94022

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Office units are available at 4300 El Camino Real, Suite 100, in Los Altos.

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Los Altos Office Space Available
Los Altos Office Space Available

779-785 Altos Oaks Dr, #Entire, Los Altos, CA 94022

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Office space for rent in Los Altos, California.

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Los Altos Office Space
Los Altos Office Space

167 San Antonio Rd S., Los Altos, CA 94022

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Office space available for rent in Los Altos, CA.

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Garden Level Office Suite
Garden Level Office Suite

4 Main St, Los Altos, CA 94022

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1,650 sqft

Garden level office suite with windows facing the courtyard, private offices, open area, conference room, and shared kitchen.

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Medical Space Sublease Opportunity
Medical Space Sublease Opportunity

Los Altos, CA 94022

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Sublease opportunity for a medical or ambulatory surgery center.

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Two-Story Standalone Office Building
Two-Story Standalone Office Building

4410 El Camino Real, Los Altos, CA 94022

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3,815 sqft

Two-entry, open-plan office building with upgraded HVAC systems and garage and surface parking.

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Los Altos, CA Office Spaces Lease Rates & Market Statistics

Browse 25 Office Spaces for lease in Los Altos, CA on Realmo, a commercial real estate marketplace serving the Los Altos area. The current inventory totals 63,125 square feet of properties — an average of ~2,550 SF per listing.

Office Spaces lease rates in Los Altos range from $5.25 SF/Yr at the entry level to $61.80 SF/Yr at the top of the market, averaging $22.76 SF/Yr. That's a 12x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. At $22.76 SF/Yr, the local average runs 8% below California's state average of $24.67 SF/Yr.

Los Altos accounts for 3% of the 802 office spaces currently available across Santa Clara County, where nearby markets include San Jose and Palo Alto. By space type, the market includes 19 office units and 4 medical office space listings.

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