West Columbia, SC Office buildings for Rent & Lease

Updated: Nov 26, 2025

Medical Office Space Available

3221, 3223, 3225, & 3231 Sunset Blvd., West Columbia, SC 29169

$20 SF/Yr

39,722 sqft

Located in Columbia’s most attractive and fastest‑growing medical office corridor.
Extremely accessible location near I‑20 and I‑26.
High traffic counts** (77,500 VPD and 86,500 VPD) at I‑20/I‑26 intersections with Highway #378.
Less than 10 minutes from Columbia’s Central Business District and Lexington.
Fronts Hwy 378, making it a commercial landmark.**

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Updated: May 14

Standalone Office Building

3320 Platt Springs Road, West Columbia, SC 29170

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1,864 sqft

Approximately 1,864 SF standalone office building
Flexible layout with multiple large private offices and open work area
Large breakroom included
13 surface parking spaces
C2 zoning approved for office, medical, and general commercial use

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Medical Office Building with Monument Signage

101 Medical Cir, West Columbia, SC 29169

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6,300 sqft

Flexible commercial office space supports medical or traditional office use.

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Office Building with Attached Garage

1110 Charleston Hwy, West Columbia, SC 29169

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2,054 sqft 1.02 AC lot

Office building on a commercial corridor with 12 parking spaces and an attached garage, zoned C-2.

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Spacious Office Building For Lease

3245 Platt Springs Rd, West Columbia, SC 29170

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60,000 sqft

Single-level office space with flexible layout and ample parking.

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Based on your search, we've compiled 16 Potential Opportunities for your consideration. Besides 5 Active listings in West Columbia, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 7 Properties for Sales.

Office buildings for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Class-A Suburban Office Building

140 Stoneridge Dr., Columbia, SC 29210

$19.50 SF/Yr

108,000 sqft

108,000 SF office building near downtown Columbia for rent.

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Demised Office Building Suites

1202 Indigo Ave, Cayce, SC 29033

Contact for pricing

5,128 sqft

Office building is subdivided into multiple suites ranging from 533 to 3,165 sf, with space available to combine.

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Large Office Building in Columbia

101 Greystone Blvd, Columbia, SC 29210

Contact for pricing

242,444 sqft

242,444 SF office building for sale in Northwest Columbia.

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Cayce Class A Office Space

1300 12th St, Cayce, SC 29033

Contact for pricing

5,555 sqft

Two-story office building with Class A space for rent.

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Similar Spaces for Sale in West Columbia, SC

Consider Similar Space for Sale. We found 7 Spaces matching your search parameters.

Standalone Office Building

570 Chris Dr, West Columbia, SC 29169

$1,200,000

5,650 sqft

Freestanding headquarters-style office with interstate access and flexible workspace configuration.

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Office Property with Car Lot Rights

1930 Augusta Road, West Columbia, SC 29169

$499,000

1,500 sqft 0.82 AC lot

Two office buildings sit on a parcel with additional rear land currently used for parking.

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West Columbia Office Space Available

3245 Platt Springs Road, West Columbia, SC 29170

$5,900,000

72,140 sqft

60,000 SF office space in Cayce/West Columbia.

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Two-Story Medical Office Building

160 Medical Circle, West Columbia, SC 29169

$1,400,000

Multi-tenant office property with elevator service, ADA access, updated roof and HVAC systems, and separate tenant access points.

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West Columbia Office Building

1110 Charleston Hwy., West Columbia, SC 29169

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2,054 sqft

2,054 SF office building for sale, lease, or redevelopment.

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Office Building with Reception

150n 9th Street, West Columbia, SC 29169

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6,100 sqft

Configured for professional operations with perimeter offices, conference space, restrooms, break rooms, and on-site parking.

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Standalone Office Building

3320 Platt Springs Road, West Columbia, SC 29170

$325,000

Standalone office building available for sale or lease along Platt Springs Road in West Columbia.

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West Columbia, SC Office buildings Lease Rates & Market Statistics

Explore 5 Office buildings for lease in West Columbia, SC on Realmo, a commercial real estate exchange covering the West Columbia area. The current inventory totals 109,940 square feet of properties.

Office buildings lease rates in West Columbia range from $20 SF/Yr at the entry level to $20 SF/Yr at the top of the market, averaging $20 SF/Yr. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. At $20 SF/Yr, the local average runs 11% below South Carolina's state average of $22.40 SF/Yr.

West Columbia accounts for 20% of the 25 office buildings currently available across Lexington County, where nearby markets include Columbia and Lexington. Office buildings make up 25% of the 20 Office Spaces currently for lease in West Columbia, with asking rates averaging $20 SF/Yr — 29% above the citywide Office Spaces average of $15.50 SF/Yr. Tenants comparing options may also consider Office Units (13 listings) and Medical Office Space (5 listings) elsewhere in the West Columbia market.