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    West Columbia, SC
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    West Columbia, SC Office Buildings for Lease

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    Cayce, SC Columbia, SC Lexington, SC Irmo, SC Hopkins, SC Blythewood, SC Gaston, SC Elgin, SC
    Medical Office Space Available
    Updated: Nov 26, 2025
    Medical Office Space Available

    3221, 3223, 3225, & 3231 Sunset Blvd., West Columbia, SC 29169

    Contact for pricing
    39,722 sqft
    Located in Columbia’s most attractive and fastest‑growing medical office corridor.
    Extremely accessible location near I‑20 and I‑26.
    High traffic counts (77,500 VPD and 86,500 VPD) at I‑20/I‑26 intersections with Highway #378.
    Less than 10 minutes from Columbia’s Central Business District and Lexington.
    Fronts Hwy 378, making it a commercial landmark.
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    Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center
    Based on your search, we've compiled 15 Potential Opportunities for your consideration. Besides 1 Active listings in West Columbia, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 6 Properties for Sales.

    Office buildings for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Cayce Class A Office Space
    Cayce Class A Office Space

    1300 12th St, Cayce, SC 29033

    Contact for pricing
    5,555 sqft

    Two-story office building with Class A space for rent.

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    Office and Warehouse Space Available
    Office and Warehouse Space Available

    2010 Rockland Rd, Columbia, SC

    Contact for pricing
    6,185 sqft

    Office and warehouse space for lease near I-20 and I-26.

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    Cayce Office/Medical Space Available
    Cayce Office/Medical Space Available

    1105 State St, Cayce, SC

    Contact for pricing
    5,670 sqft

    5,670 SF building suitable for office or medical use.

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    Modern Office Space Available
    Modern Office Space Available

    121 Executive Ctr Dr, Columbia, SC

    Contact for pricing
    3,013 sqft

    Energy Star certified office space for rent in Columbia.

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    Similar Spaces for Sale in West Columbia, SC

    Consider Similar Space for Sale. We found 6 Spaces matching your search parameters.

    West Columbia Office Space Available
    West Columbia Office Space Available

    3245 Platt Springs Road, West Columbia, SC 29170

    $5,900,000
    72,140 sqft

    60,000 SF office space in Cayce/West Columbia.

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    Standalone Office Building
    Standalone Office Building

    3320 Platt Springs Rd, West Columbia, SC 29170

    Contact for pricing
    1,864 sqft

    Standalone office building available for sale or lease along Platt Springs Road in West Columbia.

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    West Columbia Office Building
    West Columbia Office Building

    1110 Charleston Hwy., West Columbia, SC 29169

    Contact for pricing
    2,054 sqft

    2,054 SF office building for sale, lease, or redevelopment.

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    Office Building with Meeting Hall
    Office Building with Meeting Hall

    566 Chris Dr, West Columbia, SC 29169

    Contact for pricing
    3,600 sqft 1.63 AC lot

    Single-level office building on a 1.63-acre parcel with five suites, lobby, meeting hall, and conference room.

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    Spacious Office Building For Lease
    Spacious Office Building For Lease

    3245 Platt Springs Rd, West Columbia, SC

    Contact for pricing
    60,000 sqft 4.95 AC lot

    Single-level office space with flexible layout and ample parking.

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    Multi-Tenant Office Building
    Multi-Tenant Office Building

    3935-3937 Sunset Blvd, West Columbia, SC 29169

    Contact for pricing

    Multi-tenant office building with 82% occupancy and monument signage along Sunset Blvd near I-20 and I-26.

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Development Opportunity in Greenville
    Prime Development Opportunity in Greenville

    39 Airpark Ct, Greenville, SC 29607

    Contact for pricing

    1.27 acre interstate-visible land for ground lease or build-to-suit.

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    Commercial Land Build-to-Suit Opportunity
    Commercial Land Build-to-Suit Opportunity

    2683 Henderson Drive, Jacksonville, NC 28546

    $4,000/Mo
    2,400 sqft

    Commercial land available for build-to-suit in Jacksonville, NC.

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    Prime Commercial Lot For Lease
    Prime Commercial Lot For Lease

    Tift Avenue N, Tifton, GA 31794

    $7,500/Mo

    0.66 acre commercial lot in high-traffic area.

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    Corner Lot on Highway 72
    Corner Lot on Highway 72

    30472 Highway 72, Madison, AL 35756

    $5,000/Mo
    1,875 sqft

    1.7 acre corner lot zoned for commercial, medical, residential.

    View details

    West Columbia, SC Office buildings Market Trends and Statistics

    Explore Office buildings leasing options in West Columbia, SC with 1 listings featured on our commercial real estate exchange. The current inventory includes 39,722 square feet of properties.
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