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    Santa Ana, CA
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    Santa Ana, CA Office Buildings for Lease

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    Tustin, CA Laguna Niguel, CA Orange, CA
    22 results
    Premier Medical/Professional Office Building
    $2.00 SF/Yr
    107,190 SF
    Premier Medical/Professional Office Building

    1600 N Broadway, Santa Ana, CA 92701

    Renovated medical and professional office building with modern amenities.
    • Complete renovation planned to create a state‑of‑the‑art medical and professional office building.
    • Prime location in the heart of Orange County with easy access to the 5 and 55 Freeways.
    • Abundant free structured parking.
    • Approximately 50% of the building allocated for build‑to‑suit medical office suites.
    • Enjoy floor‑to‑ceiling windows with panoramic views.
    Updated: Nov 21, 2025
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    Turn-Key Class A Office Space
    $1.00 SF/Yr
    12,999,999 SF
    Turn-Key Class A Office Space

    2900 S. Harbor Blvd., Santa Ana, CA 92704

    High-image, fully renovated office space on Harbor Boulevard.
    • Turn‑key Class A Space
    • Fully Renovated with High‑End Finishes
    • High Image Space
    • Entire Building Recently Renovated
    • Fronting on Harbor Blvd.
    Updated: Apr 3
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    Professional Office Park in Santa Ana
    $1.00 SF/Yr
    173,025 SF
    Professional Office Park in Santa Ana

    Four professional office buildings in a prime Orange County location.

    515/525 Cabrillo Park & 1901/1971 E 4th St, Santa Ana, CA 92705

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    Prominent Office Building Near Freeways
    Contact for pricing
    321,836 SF
    Prominent Office Building Near Freeways

    High-visibility office building with immediate freeway access and modern amenities.

    1851 East 1st Street, Santa Ana, CA 92705

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    Class A Office Towers
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    111,721 SF
    Class A Office Towers

    Prestigious office towers with flexible floor plans and freeway access.

    5 & 6 Hutton Centre Drive, Santa Ana, CA 92707

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    Freestanding Industrial Building For Rent
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    97,967 SF
    Freestanding Industrial Building For Rent

    97,967 SF industrial building on 4.7 acres for lease.

    300 East Dyer Road, Santa Ana, CA 92707

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    Orange County Office Space Available
    $1.65 SF/Yr
    29,201 SF
    Orange County Office Space Available

    Centrally located office building with ample parking in Santa Ana.

    640 N Tustin Ave, Santa Ana, CA 92701

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    Class A Office Building
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    159,499 SF
    Class A Office Building

    10-story office building with city and mountain views.

    200 West Santa Ana Boulevard, Santa Ana, CA 92701

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    Flexible Office Space in Santa Ana
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    150,000 SF
    Flexible Office Space in Santa Ana

    Modern office building with large, versatile floor plans for rent.

    2801 North Main Street, Santa Ana, CA 92705

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    Santa Ana Office Space Available
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    Santa Ana Office Space Available

    Office space for rent with convenient freeway access.

    1551 North Tustin Avenue, Santa Ana, CA 92705

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    Santa Ana Office Space Available
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    30,000 SF
    Santa Ana Office Space Available

    Office space for rent, close to freeways and airport.

    1570 Brookhollow Drive, Santa Ana, CA 92705

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    Single Tenant Office Space
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    8,132 SF
    Single Tenant Office Space

    8,132 SqFt single tenant office space available for rent.

    501 N Parkcenter Dr, Santa Ana, CA 92705

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    Renovated Freestanding Office Building
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    Renovated Freestanding Office Building

    Four-story office building with recent renovations and high-end finishes.

    611 W Civic Center Dr, Santa Ana, CA 92701

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    Freestanding Building Near John Wayne
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    4,500 SF
    Freestanding Building Near John Wayne

    30,000 SF building near the 5 and 55 freeways.

    2000 East McFadden Avenue, Santa Ana, CA 92705

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    Office Building Near John Wayne
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    20,509 SF
    Office Building Near John Wayne

    Two-story office building conveniently located near the 55 freeway.

    2500 Red Hill Avenue, Santa Ana, CA 92705

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    Freestanding Office Building For Rent
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    6,719 SF
    Freestanding Office Building For Rent

    Freestanding office building on a large lot available for rent.

    1327 N Broadway, Santa Ana, CA

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    Santa Ana Office Building
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    Santa Ana Office Building

    Fully leased office building in Santa Ana, California.

    3730 S Susan St, Santa Ana, CA

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    Professional Office Building in Santa Ana
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    Professional Office Building in Santa Ana

    Two-story office building with elevator, close to major freeways.

    2001 East 4th Street, Santa Ana, CA 92705

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    Class A Twin Office Towers
    $34 SF/Yr
    555,993 SF
    Class A Twin Office Towers

    Prestigious office towers in South Metro, close to John Wayne Airport.

    5 & 6 Hutton Centre Dr, Santa Ana, CA 92707

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    Leased Office Building in Santa Ana
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    Leased Office Building in Santa Ana

    100% leased office building in Santa Ana, California.

    3720 S Susan St, Santa Ana, CA

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    Leased Office Building in Santa Ana
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    Leased Office Building in Santa Ana

    Fully leased office building in Santa Ana, California.

    1600 E Saint Andrew Pl, Santa Ana, CA

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    Leased Office Building in Santa Ana
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    Leased Office Building in Santa Ana

    Fully leased office building in Santa Ana, California.

    1620-1628 E 17th St, Santa Ana, CA

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    Based on your search, we've compiled 36 Potential Opportunities for your consideration. Besides 22 Active listings in Santa Ana, CA, we suggest exploring alternatives. Similar 14 Properties for Sales.

    Similar Spaces for Sale in Santa Ana, CA

    Consider Similar Space for Sale. We found 14 Spaces matching your search parameters.

    Freestanding Commercial Building in Santa Ana
    $4,295,000
    16,290 SF
    Freestanding Commercial Building in Santa Ana

    Two-story, 16,290 SF building on 0.81-acre lot.

    2215 N Broadway, Santa Ana, CA 92706

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    Santa Ana Office Building For Sale
    $14,500,000
    152,705 SF
    Santa Ana Office Building For Sale

    Nine-story office building in Downtown Santa Ana with parking garage.

    1200 N. Main St., Santa Ana, CA 92701

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    Santa Ana, CA Office buildings Leasing Opportunities Market Analysis

    Explore Office buildings leasing options in Santa Ana, CA with 22 listings featured on our commercial real estate exchange. The current inventory includes 865,409 square feet of properties with an estimated lease value of $38 SF/Yr.

    Estimated lease rates for Office buildings in Santa Ana, CA begin at $1.00 SF/Yr, with an average of $9 SF/Yr and extend to $34 SF/Yr.
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