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    San Francisco, CA Office Buildings for Lease

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    85 properties
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    Two-Story Commercial Building
    Updated: Aug 1, 2025
    Two-Story Commercial Building

    729 Bush Street, San Francisco, CA 94108

    $8,000/Mo
    5,072 sqft $18.93 SF/Yr
    Two‑story commercial building plus basement, built in 1911
    Approx. 5,072 sq ft on a 3,781 sq ft lot
    RC‑4 zoning supports a wide range of commercial uses
    Includes basement and 3 bathrooms (Bathroom 1, Bathroom 2, Bathroom 3)
    Located in San Francisco’s Lower Nob Hill, blocks from Union Square and the Financial District
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    Office Suite for Lease
    Updated: Jun 8
    Office Suite for Lease

    42 Gough Street 308, San Francisco, CA 94103

    $3,300/Mo
    34,779 sqft $1.14 SF/Yr
    Office suite available for lease at 42 Gough Street in San Francisco
    Built in 1984
    Central heating and central air conditioning
    Parking with electric gate, enclosed/private access, and leased parking
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    Class A Office Space
    Class A Office Space

    71 Stevenson St, San Francisco, CA 94105

    $57 SF/Yr
    1,993 sqft $9,466/Mo

    Prime office space in San Francisco's vibrant South Financial district.

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    Steel Framed Office Building
    Steel Framed Office Building

    244-252 California St, San Francisco, CA

    $39 SF/Yr
    2,773 sqft $9,012/Mo

    Office building featuring a unique vertical composition.

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    Prime Jackson Square Office Space
    Prime Jackson Square Office Space

    414 Jackson Street, San Francisco, CA 94111

    $39 SF/Yr
    22,716 sqft $73,827/Mo

    Classic brick and timber building in Jackson Square, San Francisco.

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    Life Science Building with Rooftop Garden
    Life Science Building with Rooftop Garden

    1800 Owens Street, San Francisco, CA 94158

    Contact for pricing
    1,139 sqft

    Large-scale life science facility with skywalk connections and rooftop gathering space for modern tenant use.

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    Historic Redstone Building in Mission
    Historic Redstone Building in Mission

    2924-2948 16th St, San Francisco, CA 94103

    $19.83 SF/Yr
    55,560 sqft $91,812/Mo

    Three-story office building in San Francisco's vibrant Mission District.

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    SOMA Building with High Ceilings
    SOMA Building with High Ceilings

    130 9th Street, San Francisco, CA 94103

    $55 SF/Yr
    25,250 sqft $115,729/Mo

    Full building available for lease in Western SOMA.

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    Full Building Opportunity in SOMA
    Full Building Opportunity in SOMA

    40 Ringold Street, San Francisco, CA 94103

    $48 SF/Yr
    3,600 sqft $14,400/Mo

    Full building opportunity in Western SOMA, San Francisco.

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    Four-Story Office Building for Lease
    Four-Story Office Building for Lease

    333 Valencia Street, San Francisco, CA 94103

    Contact for pricing
    55,685 sqft

    Four-story office building in the Mission District, with NCT zoning supporting medical and design-oriented office uses.

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    Pioneer Building Office Space
    Pioneer Building Office Space

    300 4th Street, San Francisco, CA 94107

    $38 SF/Yr
    18,000 sqft $57,000/Mo

    18,000 SF office space in the Pioneer Building.

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    Standalone Creative Office Building
    Standalone Creative Office Building

    973 Mission St, San Francisco, CA 94103

    Contact for pricing
    17,220 sqft

    Standalone building features private ground-floor entry and 18-foot ceilings with on-site shower amenities.

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    Office Space with Long Window Line
    Office Space with Long Window Line

    645 Harrison St, San Francisco, CA 94107

    Contact for pricing
    19,587 sqft

    Office space featuring a long window line designed to bring abundant natural light to the workday.

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    Historic Office Building Renovation
    Historic Office Building Renovation

    55 New Montgomery St, San Francisco, CA 94105

    Contact for pricing
    10,168 sqft

    Historic building with modern upgrades and full renovation underway.

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    Class A Office Space Available
    Class A Office Space Available

    555 Mission St, San Francisco, CA 94105

    Contact for pricing
    3,721 sqft

    Prominent 34-story Class A office building in the South Financial District.

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    Class A Office Tower
    Class A Office Tower

    655 Montgomery Street, San Francisco, CA 94111

    Contact for pricing
    103,079 sqft

    Mixed-use office tower in San Francisco's North Financial District.

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    Distinctive High-Rise Office Space
    Distinctive High-Rise Office Space

    55 2nd Street, San Francisco, CA 94105

    Contact for pricing
    386,965 sqft

    Centrally located office building in San Francisco's South Financial District.

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    Panoramic City and Bay Views
    Panoramic City and Bay Views

    1 Post St, San Francisco, CA 94104

    Contact for pricing
    967 sqft

    Office tower with customizable suites and direct mass transit access.

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    Creative Office Space Available
    Creative Office Space Available

    365 5 St, San Francisco, CA

    $12,460/Mo
    4,450 sqft $33.60 SF/Yr

    Creative office space with open floor plan and mezzanine.

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    Historic Office Building in San Francisco
    Historic Office Building in San Francisco

    400 Montgomery Street, San Francisco, CA 94111

    Contact for pricing
    39,571 sqft

    Historic 12-story office building in the heart of San Francisco.

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    Brannan Street Office Sublease
    Brannan Street Office Sublease

    501-505 Brannan St, San Francisco, CA 94107

    Contact for pricing
    20,545 sqft

    Office space available for sublease in San Francisco.

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    San Francisco Office Space Available
    San Francisco Office Space Available

    981 Mission St, San Francisco, CA 94103

    Contact for pricing
    17,220 sqft

    Office space available for lease in San Francisco, CA.

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    Class A Office Space Available
    Class A Office Space Available

    388 Market Street, San Francisco, CA 94111

    Contact for pricing
    237,661 sqft

    27-story office building in San Francisco's Financial District.

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    Class A Office in Financial District
    Class A Office in Financial District

    180 Montgomery Street, San Francisco, CA 94104

    Contact for pricing
    121,930 sqft

    LEED Platinum certified office building in San Francisco's Financial District.

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    San Francisco, CA Office buildings Market Trends and Statistics

    Explore Office buildings leasing options in San Francisco, CA with 85 listings featured on our commercial real estate exchange. The current inventory includes 669,429 square feet of properties with an estimated lease value of $551 /Mo.

    Estimated lease rates for Office buildings in San Francisco, CA begin at $1.14 SF/Yr, with an average of $34 SF/Yr and extend to $60 SF/Yr.
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