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    Poplar Bluff, MO Mixed-use Properties for Lease

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    Downtown Mixed-Use Commercial Space
    $500 / Mo
    1,200 SF

    Downtown Mixed-Use Commercial Space

    106 S Main St, Poplar Bluff, MO 63901

    1,200 sq ft mixed-use space in historic downtown Poplar Bluff.

    • Prime downtown location in historic Poplar Bluff with high traffic and visibility.
    • Flexible 1,200 sq ft mixed‑use space suitable for office, retail, studio, or professional services.
    • Street‑level storefront with excellent overhead signage potential for branding.
    • Readily available on‑street parking and a private parking lot for convenience.
    • Functional layout with 2‑3 private offices, common area, and restroom.
    Updated: Jan 19
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    Versatile Commercial Space on Highway
    $4,000 / Mo
    8,000 SF

    Versatile Commercial Space on Highway

    2323 Cheshire Blvd, Poplar Bluff, MO 63901

    8,000 sq ft building for lease or sale.

    • High‑visibility location on high‑traffic Highway 53
    • Versatile 8,000 sq ft building suitable for various commercial uses
    • Spacious parking lot to accommodate high customer volume
    • Conveniently located near industrial park, shopping centers, and retail businesses
    • Tall ceilings and large display windows
    Updated: Jul 26, 2025
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    Based on your search, we've compiled 8 Potential Opportunities for your consideration. Besides 2 Active listings in Poplar Bluff, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 2 Properties for Sales.

    Explore Mixed-use properties for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Memphis Retail Space - Monroe Blvd
    Contact for pricing
    29,112 SF

    Memphis Retail Space - Monroe Blvd

    High-profile Memphis retail, 5 suites available

    421 Monroe Blvd, Memphis, TN 38103
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    Retail Space in Midtown Memphis
    Contact for pricing

    Retail Space in Midtown Memphis

    Retail space in new mixed-use development, Midtown Memphis.

    220 S Claybrook St, Memphis, TN 38104
    View details
    Winchester Plaza Retail Spaces
    $12 SF/Yr
    5,240 SF

    Winchester Plaza Retail Spaces

    West County retail spaces, high traffic area.

    14560 Manchester Rd, Ballwin, MO 63011
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    Manchester Flex/Warehouse Space Available
    Contact for pricing
    9,632 SF

    Manchester Flex/Warehouse Space Available

    Ballwin, MO industrial space for lease. Multiple suites, high-end finishes.

    401 Sovereign Ct, Ballwin, MO 63011
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    Explore Similar Spaces for Sale in Poplar Bluff, MO

    Consider Similar Space for Sale. We found 2 Spaces in Nearby Locations matching your search parameters.

    Renovated Mixed-Use Commercial Space
    $79,900
    975 SF

    Renovated Mixed-Use Commercial Space

    Renovated commercial space with high visibility, suitable for various businesses.

    1614 S Broadway St, Poplar Bluff, MO 63901
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    Mixed-Use Property in Rural Setting
    $220,000
    4,800 SF

    Mixed-Use Property in Rural Setting

    Live and work property bordering national forest near Poplar Bluff.

    5914 Highway W, Poplar Bluff, MO 63901
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    Poplar Bluff, MO Mixed-use properties Leasing Opportunities Market Analysis

    Explore Mixed-use properties leasing options in Poplar Bluff, MO with 4 listings featured on our commercial real estate exchange. The current inventory includes 400,752,000 square feet of properties with an estimated lease value of $11 SF/Yr.

    Estimated lease rates for Mixed-use properties in Poplar Bluff, MO begin at $5 SF/Yr, with an average of $5 SF/Yr and extend to $6 SF/Yr.
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    Popular Searches in Poplar Bluff, MO

    Most Searched ZIP Codes in Poplar Bluff, MO

    • 63901

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