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    Mission, TX Medical Office Space for Sale

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    Commercial Lot in Alton, Texas
    $395,000
    0.71 Acres

    Commercial Lot in Alton, Texas

    1425 W Main Ave, Mission, TX 78573

    Prime commercial lot suitable for various business uses.

    • Highly visible corner property at Main Avenue and Los Ebanos Road.
    • Fronts on Main Avenue, a substantially completed 5 lane roadway with sidewalks.
    • Suitable for a drive‑thru coffee shop, carwash, medical or professional office, pharmacy and retail uses.
    • Adjacent to an established commercial plaza and recently developed single family residential subdivisions.
    • New single family residential subdivision under construction immediately West of Los Ebanos Road.
    Updated: Dec 28, 2025
    View details
    Mission, TX Commercial Land
    $445,000
    3.95 Acres

    Mission, TX Commercial Land

    2210 W 5 Mile Line Rd, Mission, TX 78574

    High-traffic location suitable for commercial or multifamily development.

    • Prime location suitable for commercial or multi‑family development.
    • High traffic area, ideal for business visibility.
    • Potential for rezoning to commercial use (subject to city approval).
    • Suitable for medical clinic, offices, retail, or multi‑family units.
    • Existing structures on the property, with two currently leased.
    Updated: Feb 25
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    Mission Medical Office Investment
    Contact for pricing
    9,000 SF

    Mission Medical Office Investment

    9,000 SF Medical Office, 100% Occupied

    1200 St Claire Blvd, Mission, TX 78572
    View details
    Based on your search, we've compiled 150 Potential Opportunities for your consideration. Besides 3 Active listings in Mission, TX, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 142 Off-Market properties to explore as potential leads, plus 1 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Prime Commercial Tract on Ware
    $2,995,000
    7.15 Acres

    Prime Commercial Tract on Ware

    7+/- acre commercial tract in McAllen's high-growth corridor.

    S Ware Rd, McAllen, TX 78504
    View details
    McAllen Commercial Lots: Ready to Build
    Contact for pricing
    0.62 Acres

    McAllen Commercial Lots: Ready to Build

    Prime McAllen lots, seller financing available.

    0 29Th St, McAllen, TX 78504
    View details
    Medical Office in Edinburg
    $899,000
    4,800 SF

    Medical Office in Edinburg

    4,800 sq ft medical office in Cornerstone Medical Park.

    2401 Cornerstone Blvd, Edinburg, TX 78539
    View details
    Crosspoint Business Center: Edinburg, TX
    $550,000
    2,948 SF

    Crosspoint Business Center: Edinburg, TX

    Prime Office Building, 2,948 SF, High Traffic Area

    4162 Crosspoint Blvd, Edinburg, TX 78539
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Mission, TX Commercial Land
    $445,000
    3.95 Acres

    Mission, TX Commercial Land

    High-traffic location suitable for commercial or multifamily development.

    2210 W 5 Mile Line Rd, Mission, TX 78574
    View details

    Explore Off-Market Properties in Mission, TX

    Consider similar Off-Market properties in Mission, TX. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    910 Bryan Rd

    910 Bryan Rd

    MEDICAL BUILDING • 52,693 SF
    Value Estimation
    $2,405,000
    910 Bryan Rd, Mission, TX 78572-6658
    View details
    1912 Griffin Pkwy

    1912 Griffin Pkwy

    MEDICAL BUILDING • 3,000 SF
    Value Estimation by Request
    1912 Griffin Pkwy, Mission, TX 78572-3106
    View details
    1200 Dunlap Ave

    1200 Dunlap Ave

    Medical Office Space • 2,767 SF
    Value Estimation by Request
    1200 Dunlap Ave, Mission, TX 78572
    View details
    2025 Griffin Pkwy

    2025 Griffin Pkwy

    MEDICAL BUILDING • 3,284 SF
    Value Estimation by Request
    2025 Griffin Pkwy, Mission, TX 78572-3222
    View details
    2009 Griffin Pkwy

    2009 Griffin Pkwy

    MEDICAL BUILDING • 3,138 SF
    Value Estimation by Request
    2009 Griffin Pkwy, Mission, TX 78572-3222
    View details
    2130 Griffin Pkwy

    2130 Griffin Pkwy

    MEDICAL BUILDING • 4,680 SF
    Value Estimation by Request
    2130 Griffin Pkwy, Mission, TX 78572-3225
    View details
    2112 Griffin Pkwy

    2112 Griffin Pkwy

    MEDICAL BUILDING • 3,447 SF
    Value Estimation by Request
    2112 Griffin Pkwy, Mission, TX 78572-3225
    View details
    1904 Griffin Pkwy

    1904 Griffin Pkwy

    MEDICAL BUILDING • 3,300 SF
    Value Estimation by Request
    1904 Griffin Pkwy, Mission, TX 78572-3106
    View details
    2013 Griffin Pkwy

    2013 Griffin Pkwy

    MEDICAL BUILDING • 3,138 SF
    Value Estimation by Request
    2013 Griffin Pkwy, Mission, TX 78572-3222
    View details
    2134 Griffin Pkwy

    2134 Griffin Pkwy

    MEDICAL BUILDING • 2,970 SF
    Value Estimation by Request
    2134 Griffin Pkwy, Mission, TX 78572-3225
    View details
    600 Griffin Pkwy

    600 Griffin Pkwy

    MEDICAL BUILDING • 7,429 SF
    Value Estimation by Request
    600 Griffin Pkwy, Mission, TX 78572-2980
    View details
    1512 Griffin Pkwy

    1512 Griffin Pkwy

    MEDICAL BUILDING • 3,600 SF
    Value Estimation by Request
    1512 Griffin Pkwy, Mission, TX 78572-2416
    View details
    1022 Griffin Pkwy

    1022 Griffin Pkwy

    MEDICAL BUILDING • 2,400 SF
    Value Estimation by Request
    1022 Griffin Pkwy, Mission, TX 78572-2400
    View details
    1022 Griffin Pkwy

    1022 Griffin Pkwy

    MEDICAL BUILDING • 3,000 SF
    Value Estimation by Request
    1022 Griffin Pkwy, Mission, TX 78572-2400
    View details
    910 8th St, Unit 2

    910 8th St, Unit 2

    MEDICAL BUILDING • 3,200 SF
    Value Estimation by Request
    910 8th St, Mission, TX 78572
    View details
    1300 Bryan Rd

    1300 Bryan Rd

    MEDICAL BUILDING • 3,000 SF
    Value Estimation by Request
    1300 Bryan Rd, Mission, TX 78572-6626
    View details
    1300 Bryan Rd

    1300 Bryan Rd

    MEDICAL BUILDING • 9,000 SF
    Value Estimation
    $660,000
    1300 Bryan Rd, Mission, TX 78572-6626
    View details
    1300 Bryan Rd

    1300 Bryan Rd

    MEDICAL BUILDING • 3,000 SF
    Value Estimation by Request
    1300 Bryan Rd, Mission, TX 78572-6626
    View details
    1317 Bryan Rd

    1317 Bryan Rd

    MEDICAL BUILDING • 4,860 SF
    Value Estimation by Request
    1317 Bryan Rd, Mission, TX 78572
    View details
    308 Bryan Rd

    308 Bryan Rd

    MEDICAL BUILDING • 3,781 SF
    Value Estimation by Request
    308 Bryan Rd, Mission, TX 78572-6222
    View details
    3003 Conway Ave

    3003 Conway Ave

    MEDICAL BUILDING • 2,000 SF
    Value Estimation by Request
    3003 Conway Ave, Mission, TX 78574-2103
    View details

    Mission, TX Medical Office Space Investment Opportunities Market Analysis

    Explore 145 medical office space for sale in Mission, TX, showcased through 3 active listings on our real estate platform. These investment opportunities span a total of 2,132,231 square feet of properties for sale, with an estimated market value of $40,635,000.

    Sale prices for medical spaces in Mission, TX start at $280,000, averaging $335,826, and reaching up to $645,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Most Searched ZIP Codes in Mission, TX

    • 78572
    • 78573
    • 78574

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