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    Southlake, TX Medical Office Space for Lease

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    Grapevine, TX Colleyville, TX Keller, TX
    15 results
    Southlake Office Space Available
    $23 SF/Yr

    Southlake Office Space Available

    325 Miron Drive, Southlake, TX 76092

    Professional office suite for rent in Southlake, Texas.

    • Prime Location: Minutes from restaurants, retail, and DFW Airport
    • Ample Parking: Dedicated parking lot for tenants and visitors
    • Excellent Visibility: High visibility location within Miron Place
    • Convenient Access: Easy access to State Highways 114, 26, and 121
    • Versatile Use: Ideal for both office and medical tenants
    Updated: Feb 23
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    Medical/Physical Therapy Space Available
    $21 SF/Yr
    7,047 SF

    Medical/Physical Therapy Space Available

    1220 N Kimball Ave, Southlake, TX 76092

    Sublease available in Southlake near Hwy 114 & DFW Airport.

    • Built‑out Medical/Physical Therapy Space
    • Convenient Location: Faces Kimball Ave, near Hwy 114 & DFW Airport
    • Ample Parking
    • Sublease Available: 2,824 SF
    • Sublease Term: 11/1/25 through 11/30/2030
    Updated: Nov 26, 2025
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    Southlake Office Suite Available
    $23 SF/Yr
    1,000 SF

    Southlake Office Suite Available

    Professional office suite for lease in Southlake, Texas.

    325 Miron Drive, Southlake, TX 76092
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    Southlake Medical Office Space Available
    Contact for pricing
    5,263 SF

    Southlake Medical Office Space Available

    Class A medical office space in Southlake, Texas for rent.

    431 E State Highway 114, Southlake, TX
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    Southlake Medical Office Space Available
    Contact for pricing
    2,942 SF

    Southlake Medical Office Space Available

    Class A medical office space with signage available for lease.

    731 E Southlake Blvd, Southlake, TX
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    Southlake Medical/Office Condo Available
    Contact for pricing
    3,205 SF

    Southlake Medical/Office Condo Available

    Medical/office condo with signage and tenant improvement allowance in Southlake.

    3065 W Southlake Blvd, Southlake, TX
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    Southlake Medical/Office Condo Available
    Contact for pricing
    2,914 SF

    Southlake Medical/Office Condo Available

    Medical/Office condo with signage and tenant improvement allowance.

    3055 W Southlake Blvd, Southlake, TX
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    Medical Office Space For Rent
    Contact for pricing
    2,040 SF

    Medical Office Space For Rent

    Office space connected to Texas Health Harris Methodist Hospital Southlake.

    1545 E Southlake Boulevard, Southlake, TX
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    Move-In Ready Medical Office Space
    $24 SF/Yr
    1,545 SF

    Move-In Ready Medical Office Space

    Turnkey medical office space with building signage and ample parking.

    2813 W Southlake Blvd, Southlake, TX
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    Medical/Office Space Near Southlake Blvd
    Contact for pricing

    Medical/Office Space Near Southlake Blvd

    Medical/office space near shopping and residential areas.

    1100 E Southlake Blvd, Southlake, TX 76092
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    Southlake Medical Office Space Available
    Contact for pricing

    Southlake Medical Office Space Available

    Class A medical office space in thriving Southlake, Texas.

    245 W State Hwy 114, Southlake, TX 76092
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    Medical Office Building For Lease
    Contact for pricing

    Medical Office Building For Lease

    Multi-tenant medical office building for lease in Southlake, TX.

    2435 E Southlake Blvd, Southlake, TX 76092
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    Southlake Office Space For Sublease
    Contact for pricing
    8,052 SF

    Southlake Office Space For Sublease

    Former dental office with highway exposure and ample parking.

    2600 E State 114 Hwy, Southlake, TX
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    Medical Office Space in Southlake
    Contact for pricing

    Medical Office Space in Southlake

    Class A medical office space available for lease in Southlake.

    925 E Southlake Blvd, Southlake, TX 76092
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    Move-In Ready Office Space Available
    $19 SF/Yr
    2,080 SF

    Move-In Ready Office Space Available

    Professional/Medical office space available for lease, move-in ready.

    2485 E Southlake Blvd, Southlake, TX
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    Based on your search, we've compiled 32 Potential Opportunities for your consideration. Besides 15 Active listings in Southlake, TX, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 9 Properties for Sales.

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Move-in Ready Medical Office Space
    $24 SF/Yr
    2,482 SF

    Move-in Ready Medical Office Space

    Furnished medical office space ready for immediate operation.

    2321 Ira E Woods Avenue #Suite 120, Grapevine, TX 76051
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    Colleyville Office/Medical Suites Available
    $18 SF/Yr
    5,683 SF

    Colleyville Office/Medical Suites Available

    Move-in ready office/medical suites with signage and tenant improvement allowance.

    6221 Colleyville Blvd, Colleyville, TX
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    Move-In Ready Office/Medical Suites
    $18 SF/Yr
    3,885 SF

    Move-In Ready Office/Medical Suites

    Second-generation office/medical suites with tenant improvement allowance.

    6211 Colleyville Blvd, Colleyville, TX
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    Former Medical Office Space Available
    Contact for pricing

    Former Medical Office Space Available

    Turnkey medical office space in Grapevine, near Hwy 114.

    2011 W Northwest Hwy, Grapevine, TX 76051
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    Similar Spaces for Sale in Southlake, TX

    Consider Similar Space for Sale. We found 9 Spaces matching your search parameters.

    Class A Medical Development
    $2,310,000
    6,000 SF

    Class A Medical Development

    Class A medical development with spaces available for sale.

    731 Zena Rucker Road B, Southlake, TX 76092
    View details
    Southlake Class A Medical Development
    $640,000
    2.25 Acres

    Southlake Class A Medical Development

    Class A medical development in Southlake, delivering Spring 2025.

    731 Zena Rucker Road, Southlake, TX 76092
    View details
    Southlake Class A Medical Development
    $2,310,000
    6,000 SF

    Southlake Class A Medical Development

    Class A medical office development in Southlake, delivering Spring 2025.

    731 Zena Rucker Road, Southlake, TX 76092
    View details
    Class A Medical Development
    $4,370,000
    2.25 Acres

    Class A Medical Development

    Class A medical development in Southlake, TX, delivering Spring 2025.

    731 Zena Rucker Road, Southlake, TX 76092
    View details
    Class A Medical Development
    $1,755,000
    2.25 Acres

    Class A Medical Development

    Class A medical office development in Southlake, TX. Delivering Spring 2025.

    731 Zena Rucker Road, Southlake, TX 76092
    View details
    Southlake Class A Medical Development
    $1,185,000
    2.25 Acres

    Southlake Class A Medical Development

    Class A medical office development in Southlake, delivering Spring 2025.

    731 Zena Rucker Road, Southlake, TX 76092
    View details
    Class A Medical Development
    $2,310,000
    6,000 SF

    Class A Medical Development

    Medical office space for sale, delivering Spring 2025.

    731 Zena Rucker Road #B, Southlake, TX 76092
    View details
    Medical Office Portfolio in Southlake
    Contact for pricing
    9,400 SF

    Medical Office Portfolio in Southlake

    Six-building medical office portfolio with high visibility in Southlake, TX.

    2520 E State Hwy 114, Southlake, TX
    View details
    Southlake Medical Office Portfolio
    Contact for pricing
    9,400 SF

    Southlake Medical Office Portfolio

    Medical office space for lease in Southlake, Texas.

    2560 E State Hwy 114, Southlake, TX
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    El Paso Commercial Land Lease
    $3,600/Mo

    El Paso Commercial Land Lease

    Commercial land for lease in a strategic El Paso location.

    5538 E Paisano Drive, El Paso, TX 79905
    View details
    Highway 72 Corner Lot
    $6,500/Mo
    1,875 SF

    Highway 72 Corner Lot

    1.6 acre commercial lot for rent on Highway 72.

    30472 Highway 72, Madison, AL 35756
    View details
    Grand Junction Commercial Land Lease
    $9,656/Mo

    Grand Junction Commercial Land Lease

    0.74 acre commercial land for lease in Grand Junction.

    Highway 6&50, Grand Junction, CO 81505
    View details
    Grand Junction Commercial Land Opportunity
    $17,728/Mo

    Grand Junction Commercial Land Opportunity

    1.36 acre commercial land for lease in Grand Junction.

    Sanford Drive, Grand Junction, CO 81505
    View details

    Southlake, TX Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Southlake, TX with 15 listings featured on our commercial real estate exchange. The current inventory includes 11,672 square feet of properties with an estimated lease value of $87 SF/Yr.

    Estimated lease rates for Medical Office Space in Southlake, TX begin at $19 SF/Yr, with an average of $21 SF/Yr and extend to $24 SF/Yr.
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