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    Southlake, TX Medical Office Space for Lease

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    12 properties
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    Medical/Physical Therapy Space Available
    Updated: Nov 26, 2025
    Medical/Physical Therapy Space Available

    1220 N Kimball Ave, Southlake, TX 76092

    $21 SF/Yr
    7,047 sqft
    Built‑out Medical/Physical Therapy Space
    Convenient Location: Faces Kimball Ave, near Hwy 114 & DFW Airport
    Ample Parking
    Sublease Available: 2,824 SF
    Sublease Term: 11/1/25 through 11/30/2030
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    Class A Medical Office Space
    Updated: Jun 2
    Class A Medical Office Space

    731 E Southlake Blvd, Southlake, TX 76092

    Contact for pricing
    13,827 sqft
    Class A medical office space
    Large block of contiguous space
    2nd generation medical space
    Generous tenant improvement allowance available
    Opportunity for personalized signage
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    Move-In Ready Office Suite
    Move-In Ready Office Suite

    2111 Kirkwood Blvd., Southlake, TX 76092

    Contact for pricing
    2,020 sqft

    Premium office/medical suite is fully built out with high-end finishes, including granite countertops and tile and wood flooring.

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    Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
    Newly Constructed Medical Office Space
    Newly Constructed Medical Office Space

    731 Zena Rucker Rd, Southlake, TX 76092

    Contact for pricing
    11,181 sqft

    Newly constructed modern office and medical space offering 22,581 SF.

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    Medical Office Suite
    Medical Office Suite

    2915 E Southlake Blvd, Southlake, TX 76092

    Contact for pricing
    2,635 sqft

    Medical office suite features six treatment rooms, reception and waiting area, patient restrooms, and private consultation space.

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    Class A Medical Office Suite
    Class A Medical Office Suite

    731 E Southlake Blvd, Southlake, TX 76092

    Contact for pricing
    3,413 sqft

    Class A medical office space with a large contiguous layout and monument signage, including a tenant improvement allowance.

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    Class A Medical Office Suite
    Class A Medical Office Suite

    731 E Southlake Blvd, Southlake, TX 76092

    Contact for pricing
    8,828 sqft

    Class A medical office space offering a large contiguous block and monument signage.

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    Class A Medical Office Suite
    Class A Medical Office Suite

    731 E Southlake Blvd, Southlake, TX 76092

    Contact for pricing
    1,586 sqft

    Class A medical office space with monument signage and generous tenant improvement allowance.

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    Class A Medical Office Sublease
    Class A Medical Office Sublease

    245 W State Highway 114, Southlake, TX 76092

    Contact for pricing
    2,095 sqft

    2,095 SF Class A medical office sublease with 40 months remaining on the underlying lease.

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    Move-In Ready Medical Office Space
    Move-In Ready Medical Office Space

    2813 W Southlake Blvd, Southlake, TX

    Contact for pricing
    1,545 sqft

    Turnkey medical office space with building signage and ample parking.

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    Southlake Medical Office Space Available
    Southlake Medical Office Space Available

    245 W State Hwy 114, Southlake, TX 76092

    Contact for pricing

    Class A medical office space in thriving Southlake, Texas.

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    Medical Office Building For Lease
    Medical Office Building For Lease

    2435 E Southlake Blvd, Southlake, TX 76092

    Contact for pricing

    Multi-tenant medical office building for lease in Southlake, TX.

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    Based on your search, we've compiled 34 Potential Opportunities for your consideration. Besides 12 Active listings in Southlake, TX, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 14 Properties for Sales.

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Furnished Medical Office Space
    Furnished Medical Office Space

    2321 Ira E Woods Avenue Suite 120, Grapevine, TX 76051

    $21 SF/Yr
    2,482 sqft

    Clinical suite includes furnishings, treatment equipment, and beds for immediate practice operations.

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    Class A Professional Office Suite
    Class A Professional Office Suite

    1120 Glade Road, Colleyville, TX 76034

    Contact for pricing
    1,056 sqft

    Move-in-ready office suite with dedicated conference room in a Colleyville business corridor location.

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    Professional Office Suites
    Professional Office Suites

    1706 Tennison Parkway, Colleyville, TX 76034

    Contact for pricing
    3,377 sqft

    Well-maintained office building with two available suites and updated interiors, supported by private offices and restrooms.

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    Medical Office Suite with Signage
    Medical Office Suite with Signage

    2321 Ira E. Woods, Grapevine, TX 76051

    Contact for pricing

    Medical-oriented office space suited for a primary or secondary practice with reconfiguration options.

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    Similar Spaces for Sale in Southlake, TX

    Consider Similar Space for Sale. We found 14 Spaces matching your search parameters.

    Class A Medical Development Two Buildings
    Class A Medical Development Two Buildings

    731 Zena Rucker Road, Southlake, TX 76092

    $2,310,000
    6,000 sqft 2.25 AC lot

    Class A medical development under construction, delivering Spring 2025, with space availability across two buildings.

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    Class A Medical Office Development
    Class A Medical Office Development

    731 Zena Rucker Road E, Southlake, TX 76092

    $640,000
    11,400 sqft

    Class A medical development featuring two buildings with suites available, delivering Spring 2025 adjacent to Rockenbaugh Elementary.

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    Class A Medical Office Development
    Class A Medical Office Development

    731 Zena Rucker Road D, Southlake, TX 76092

    $1,185,000
    11,400 sqft

    Two-building medical development with suites ranging from 2,900 to 11,400 sf delivering Spring 2025.

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    Class A Medical Office Development
    Class A Medical Office Development

    731 Zena Rucker Road #E, Southlake, TX 76092

    $640,000
    1,600 sqft

    Class A medical development with two building options delivering in Spring 2025.

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    Class A Medical Development
    Class A Medical Development

    731 Zena Rucker Road #B, Southlake, TX 76092

    $2,310,000
    6,000 sqft

    Medical office space for sale, delivering Spring 2025.

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    Two-Building Medical Office Development
    Two-Building Medical Office Development

    731 Zena Rucker Road, Southlake, TX 76092

    $640,000
    2.25 AC lot

    Two-building medical office development under construction, delivering Spring 2025 with available suites from 2,900 to 11,400 SF.

    View details
    Class A Medical Office Development
    Class A Medical Office Development

    731 Zena Rucker Road # A, Southlake, TX 76092

    $4,370,000
    11,400 sqft

    Two-building Class A medical development with suites ranging from 2,900 to 11,400 sf, delivering Spring 2025.

    View details
    Class A Medical Office Development
    Class A Medical Office Development

    731 Zena Rucker Road, Southlake, TX 76092

    $1,185,000
    2.25 AC lot

    Class A medical development with two buildings and multiple suite size options, under construction for Spring 2025 delivery.

    View details
    Class A Medical Development with Two Buildings
    Class A Medical Development with Two Buildings

    731 Zena Rucker Road, Southlake, TX 76092

    $1,755,000
    2.25 AC lot

    Class A medical development under construction next to Rockenbaugh Elementary School, delivering Spring 2025.

    View details
    Class A Medical Office Development
    Class A Medical Office Development

    731 Zena Rucker Road, Southlake, TX 76092

    $4,370,000
    2.25 AC lot

    Class A medical office development with two buildings under construction, delivering spring 2025 next to Rockenbaugh Elementary School.

    View details
    New Medical Office Building
    New Medical Office Building

    731 Zena Rucker Rd, Southlake, TX 76092

    Contact for pricing
    11,400 sqft

    Newly constructed 2025 modern building suited for office and medical users in Southlake.

    View details
    Class A Medical Development
    Class A Medical Development

    731 Zena Rucker Road C, Southlake, TX 76092

    $1,755,000

    Two-building medical development with suites available from 2,900 to 11,400 sf, delivering Spring 2025.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Office Development Land For Lease
    Office Development Land For Lease

    1323 Strawfloor Drive, Jonesboro, AR 72401

    Contact for pricing
    4,000 sqft

    2.43 acres for office development with build-to-suit opportunity.

    View details
    Commercial Land for Long-Term Lease
    Commercial Land for Long-Term Lease

    5538 E Paisano Drive, El Paso, TX 79905

    $5,950/Mo

    Lease a C4-zoned lot with easy interstate access, suited for a range of business and professional uses.

    View details
    Corner Office Unit
    Corner Office Unit

    30472 Highway 72, Madison, AL 35756

    $5,000/Mo
    1,875 sqft

    C4 zoning allows commercial, medical, and residential uses at this accessible corner property.

    View details
    Prime Lexington Outlot Opportunity
    Prime Lexington Outlot Opportunity

    3330 Partner Place, Lexington, KY 40503

    Contact for pricing

    Outlot for ground lease or build-to-suit in South Lexington.

    View details

    Southlake, TX Medical Office Space Market Trends and Statistics

    Explore Medical Office Space leasing options in Southlake, TX with 12 listings featured on our commercial real estate exchange. The current inventory includes 54,177 square feet of properties with an estimated lease value of $21 SF/Yr.

    Estimated lease rates for Medical Office Space in Southlake, TX average $21 SF/Yr.
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