Monroe County, PA Medical Office Space for Lease

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Updated: May 14

Freestanding Office Building

5226 Milford Road, East Stroudsburg, PA 18302

$2,995/Mo

1,855 sqft

Freestanding commercial building for lease with visibility to more than 19,000 vehicles per day
Includes reception/waiting area with natural stone fireplace plus open office area and restroom
Two glass‑walled conference rooms and three private offices
Outside features two large signs and 16 parking spaces
Utilities: well water and public sewer; heating includes electric and propane

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Updated: Oct 30, 2025

East Stroudsburg Professional Office Suite

507 Seven Bridge Road, East Stroudsburg, PA 18301

$3,250/Mo

2,165 sqft

Ideal location on busy Route 209 with high traffic count (18,000+ daily) for excellent visibility and convenience.
Professional and Medical Office Building suitable for office or medical use.
Convenient access to I‑80.
ADA accessibility and elevator enhance customer/patient experience.
Interior courtyard provides an elevated business image.

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East Stroudsburg Office Space Available

507 Seven Bridge Road, East Stroudsburg, PA 18301

$675/Mo

450 sqft

Professional/Medical office space for rent in East Stroudsburg, PA.

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COMMERCIAL - East Stroudsburg, PA

106 Shawnee Sq Dr, Unit FIRST, East Stroudsburg, PA 18301

$12 SF/Yr

Adaptable 4,610 SF space in high-traffic Shawnee Square.

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Commercial Units with Private Entrances

Brodheadsville, PA 18322

$1,600/Mo

Three updated units are available for build-to-suit leasing with private entrances, bathrooms, and separate electric meters.

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Stroudsburg Commercial Space For Rent

828 Monroe Street, Stroudsburg, PA 18360

$2,250/Mo

2,100 sqft

2,100 SF commercial space suitable for office, medical, or retail.

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Tobyhanna Professional/Medical Office Suite

100 Community Drive, Tobyhanna, PA 18466

$2,750/Mo

54,000 sqft

Professional/Medical office suite in Class A building for rent.

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Stroudsburg Medical Office Space

1845 W Main St, Stroudsburg, PA

$18 SF/Yr

6,000 sqft

Class A medical office space for lease in Stroudsburg.

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Partitionable Medical Office/Retail Space

106 Shawnee Square Dr, First Floor, East Stroudsburg, PA 18301

$12/Mo

4,610 sqft

First-floor space can be leased as one unit or partitioned into two, with ADA-compliant layout and on-site parking.

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East Stroudsburg Office/Medical Space

507 Seven Bridges Road, East Stroudsburg, PA 18301

$1,275/Mo

651 sqft

Professional office building near I-80 on Route 209.

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Based on your search, we've compiled 24 Potential Opportunities for your consideration. Besides 10 Active listings in Monroe County, PA, we suggest exploring alternatives. Similar 10 Properties for Sales.

Similar Spaces for Sale in Monroe County, PA

Consider Similar Space for Sale. We found 10 Spaces matching your search parameters.

Commercial Building in Mount Pocono

1355 Pocono Boulevard, Mount Pocono, PA 18344

$429,900

3,416 sqft 0.21 AC lot

Commercial office building suitable for various professional uses.

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Stroudsburg Commercial Investment Opportunity

1674 N 9th Street, Stroudsburg, PA 18360

$1,600,000

4,328 sqft 1.15 AC lot

Commercial investment property with diversified income stream and in-place tenancy.

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Commercial Building on Busy Route

2176 Route 115, Brodheadsville, PA 18322

$459,000

2,930 sqft 1.00 AC lot

Commercial building on Route 115, perfect for medical or professional services.

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Medical Office Building with Parking

371 E Brown Street, East Stroudsburg, PA 18301

$599,000

5,484 sqft 1.07 AC lot

Multi-unit medical and office building offers three suites, ample parking, and strong access for professional users.

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Live-Work Commercial Building

18 Fork Street, Mount Pocono, PA 18344

$649,900

4,700 sqft 0.11 AC lot

Mixed-use layout combines office space, a two-bedroom apartment, and an oversized garage with ample off-street parking.

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Professional/Medical Office Building For Sale

300 Community Drive, Tobyhanna, PA 18466

$2,950,000

18,444 sqft 2.56 AC lot

18,400 sq ft professional/medical office building in Tobyhanna, PA.

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Three-Story Office Building with Parking

1377 Pocono Boulevard, Mount Pocono, PA 18344

$399,800

3,956 sqft 0.32 AC lot

Three-story commercial building with off-street parking for 20+ vehicles, including an active third-floor tenant space.

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Corner Commercial Development Site