Greenville, NC Medical Office Space for Lease & Rent: Medical Spaces Near You

Updated: Apr 23

Medical Office Building

905 Johns Hopkins Dr, Greenville, NC 27834

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20,458 sqft 4.35 AC lot

20,458 SF medical office building built in 1989 on a 4.35‑acre site in Greenville, NC.
Adjacent to ECU Health Medical Center and the Brody School of Medicine.
Fully leased to ECU Physicians with State of North Carolina rent‑backed credit (AA-).
Lease provides 2% annual rent escalations through Feb. 2028.
Projected 2026 gross rental income of $465,243.78 and estimated operating expenses of $107,973.12 for NOI of $357,270.66.

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Updated: May 5

Medical Office Suite with Exam Rooms

1970 W Arlington Blvd, Greenville, NC 27834

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1,852 sqft

1,852 SF Class B office space available for lease
Medical office layout with four (4) dedicated exam rooms
Reception/lobby area plus break room
Includes restrooms within the suite
Designed for medical, wellness, or professional office use with minimal buildout required

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Renovated Medical Office Building

2450 Emerald Place, Greenville, NC 27834

$22 SF/Yr

Stand-alone medical building with 11 exam rooms, reception area, and six offices, fully renovated in 2026.

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Medical Office Space with Clinical Build-Out

2711 E 10th St, Greenville, NC 27858

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Multi-suite medical space includes exam rooms, offices, lab facilities, waiting areas, and on-site parking.

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Based on your search, we've compiled 16 Potential Opportunities for your consideration. Besides 4 Active listings in Greenville, NC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 8 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Second-Floor Office Units

105 Douglas Street E, Wilson, NC 27893

$3,334/Mo

2,900 sqft 0.12 AC lot

Dedicated elevator and separate stair access serve the upper-level office layout.

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Second-Floor Office Units

105 Douglas Street E, Wilson, NC 27893

$3,334/Mo

3,000 sqft

Elevator and stair access serve flexible office space in downtown Wilson.

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Medical Office Space

2400 Wayne Memorial Drive, Goldsboro, NC 27534

$3,500/Mo

2,417 sqft 0.10 AC lot

Established medical office property with electric heating and O&I-I zoning.

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Medical Office Suite

2400 Wayne Memorial Drive, Goldsboro, NC 27534

$3,500/Mo

2,096 sqft

Office suite in a medical pavilion with vinyl and carpet flooring and O&I zoning.

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Similar Spaces for Sale in Greenville, NC

Consider Similar Space for Sale. We found 8 Spaces matching your search parameters.

Single-Tenant Office Building on Corner

601 Greenville Blvd SE, Greenville, NC 27858

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5,220 sqft 0.56 AC lot

5,220 SF office building with on-site parking and direct access on a high-visibility corner retail corridor.

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Single-Tenant Corner Office Building

601 Greenville Blvd SE, Greenville, NC 27858

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5,225 sqft 0.56 AC lot

5,220 SF single-tenant office on a corner with on-site parking and direct access to Greenville Blvd.

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Fully Leased Medical Office Building

905 Johns Hopkins Dr, Greenville, NC 27834

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20,458 sqft 4.35 AC lot

20,458 SF medical office on 4.35-acre site, leased to ECU Physicians with lease expiring Feb. 29, 2028.

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Standalone Medical Office Space

2303 Executive Circle, Greenville, NC 27834

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6,000 sqft

Vacant single-story property positioned in Greenville’s medical district.

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Freestanding Office Building

2305 Executive Circle, Greenville, NC 27834

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10,872 sqft

Vacant single-story property across from ECU Health Medical Center in Greenville’s medical district.

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Medical Office Investment with Metal Roof

2150 Herbert Court, Greenville, NC 27834

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11,441 sqft 1.24 AC lot

Fully leased medical office with standing seam metal roof and a lease extending through December 31, 2031.

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Medical Office Suite with Exam Rooms

2340 Hemby Ln, Greenville, NC 27834

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3,220 sqft

Medical office suite includes six exam rooms with sinks, nurse stations, and ample parking.

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Medical Office Pad Sites

2420 Emerald Place, Greenville, NC 27834

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16,988 sqft

Foundation-ready medical office sites in Greenville's medical district.

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Greenville, NC Medical Office Space Lease Rates & Market Statistics

Browse 4 Medical Office Space listings for lease in Greenville, NC on Realmo, a commercial real estate marketplace serving the Greenville area. The current inventory totals 22,310 square feet of properties.

Medical Office Space lease rates in Greenville range from $22 SF/Yr at the entry level to $22 SF/Yr at the top of the market, averaging $22 SF/Yr. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $22 SF/Yr is in line with the North Carolina state average.

Greenville accounts for 80% of the 5 medical office space listings currently available across Pitt County, where a nearby market includes Farmville. Medical Office Space is one of the more limited space types in Greenville, with just 4 listings currently available — a scarcity worth factoring into lease negotiations. Tenants comparing options may also consider Office Units (18 listings) elsewhere in the Greenville market.