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    Jefferson County, KY Medical Office Space for Lease

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    St. Matthews Class A Office
    Updated: Mar 25
    St. Matthews Class A Office

    4500 Bowling Boulevard, Louisville, KY 40207

    $26 SF/Yr
    12,710 sqft · $27,538/Mo
    Prime "Plug & Play" office space available immediately with furniture included.
    Unparalleled access to downtown and the East End with convenient access to I‑64 and I‑264.
    Located in the Dupont Medical District, less than a half mile from three major hospitals.
    Lowest vacancy rate in the market.
    Abundant amenities within a mile, including restaurants, hospitality, fitness centers, and shopping.
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    Office Space Near Holiday Manor
    Updated: Nov 22, 2025
    Office Space Near Holiday Manor

    4912 U.S. 42, Louisville, KY 40222

    $25 SF/Yr
    8,385 sqft · $17,468/Mo
    Excellent visibility and access
    Suites from 1,011± SF to 6,936± SF available
    Across US Hwy 22 from the new VA Hospital
    Located near the US 42 / I‑264 Interchange
    Medical and traditional office space available
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    Retail and Office Center
    Retail and Office Center

    7280 Dixie Hwy, Louisville, KY 40258

    Contact for pricing

    Redeveloped center offers multiple first-floor retail suites and second-floor office space with flexible build-out options.

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    Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center
    Prime Commercial Space in Fern Creek
    Prime Commercial Space in Fern Creek

    5700 Bardstown Rd, Louisville, KY

    Contact for pricing
    4,980 sqft

    4980 sqft C1 zoned space available December 2025.

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    Eastwood Mixed-Use Development Opportunity
    Eastwood Mixed-Use Development Opportunity

    16223 Shelbyville Rd, Louisville, KY 40245

    $25 SF/Yr
    124,160 sqft · $258,666/Mo

    Mixed-use development near Publix with office, retail, and medical space.

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    Downtown Louisville Medical Office Space
    Downtown Louisville Medical Office Space

    645 Roy Wilkins Ave, Louisville, KY 40203

    $15 SF/Yr

    Medical office space in Downtown Louisville's Central Business District.

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    Freestanding Retail and Medical Building
    Freestanding Retail and Medical Building

    8715 3rd Street Road, Louisville, KY 40272

    Contact for pricing
    9,290 sqft

    Freestanding 2010-built facility with 24-space parking and flexible open floor plan for service, medical, or retail use.

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    Medical Office Suite in Office Building
    Medical Office Suite in Office Building

    4036 Dutchmans Lane, Louisville, KY 40207

    Contact for pricing
    1,800 sqft

    1,800 SF office space behind Pro Scan Imaging, formerly a home health agency, across from Norton Women’s and Children’s.

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    New Mixed-Use Development, Louisville
    New Mixed-Use Development, Louisville

    1041 Zorn Ave, Louisville, KY 40207

    Contact for pricing

    New Class A mixed-use development coming in 2026.

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    Medical Clinic & Office Building
    Medical Clinic & Office Building

    9616 Dixie Hwy, Louisville, KY 40272

    Contact for pricing
    10,500 sqft

    Medical clinic and office building in high-traffic area.

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    Retail Space in Fern Creek
    Retail Space in Fern Creek

    7931 Bardstown Rd, Louisville, KY 40291

    Contact for pricing
    6,000 sqft

    Class-A retail space in high-growth Fern Creek trade area.

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    Based on your search, we've compiled 25 Potential Opportunities for your consideration. Besides 11 Active listings in Jefferson County, KY, we suggest exploring alternatives. Similar 10 Properties for Sales.

    Similar Spaces for Sale in Jefferson County, KY

    Consider Similar Space for Sale. We found 10 Spaces matching your search parameters.

    Four-Unit Office Condominium
    Four-Unit Office Condominium

    3401 Stony Spring Circle, Louisville, KY 40220

    $825,000
    5,600 sqft · 52.90 AC lot

    All-brick two-story office condominium with four individual suites for professional and medical uses, plus ample parking.

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    Former JCPS Childcare Education Center
    Former JCPS Childcare Education Center

    7401 Riverport Dr, Louisville, KY 40258

    $995,000
    8,935 sqft · 3.00 AC lot

    Well-maintained 8,900 SF building on 3+ acres, suitable for various uses.

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    Medical Center on Healthcare Corridor
    Medical Center on Healthcare Corridor

    4730 CHAMPIONS TRACE LN, Louisville, KY 40218

    $4,565,614
    7,907 sqft

    Located on a major East Louisville medical and retail corridor with fast interstate access for outpatient and dialysis services.

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    Freestanding Medical Office in St. Matthews
    Freestanding Medical Office in St. Matthews

    217 Breckenridge Ln, Louisville, KY 40207

    $700,000
    2,183 sqft

    Two-story medical office with basement and on-site parking.

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    Single-Level Office Building with Patio
    Single-Level Office Building with Patio

    908 Minoma Avenue, Louisville, KY 40217

    $625,000
    3,061 sqft

    Single-level office with private patio, abundant natural light, and multiple offices suited for professional and specialty uses.

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    Move-in Ready Office Condominium
    Move-in Ready Office Condominium

    1300 Gardiner Lane, Louisville, KY

    $125,000
    1.60 AC lot

    Well-maintained office condo in Gardiner Lane Professional Office Park.

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    Turnkey Dental Office Suite
    Turnkey Dental Office Suite

    3046 Breckenridge Ln, Louisville, KY 40220

    $150,000

    Well-maintained dental office suite with multiple treatment rooms and reception, located within a professional office complex.

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    Medical/Office Building Near UofL Hospital
    Medical/Office Building Near UofL Hospital

    1700 Old Bluegrass Ave, Louisville, KY 40215

    $2,100,000
    21,286 sqft

    Well-located medical/office building near UofL Hospital, available for sale or lease.

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    Two-Tenant Oral Surgery Investment
    Two-Tenant Oral Surgery Investment

    2800 Cannons Ln, Louisville, KY 40205

    $6,634,621
    11,787 sqft

    Two-tenant oral surgery property with a 7.22% cap rate.

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    Medical Office in Outpatient Center
    Medical Office in Outpatient Center

    225 Abraham Flexner Way, Louisville, KY 40202

    $595,000
    3,005 sqft

    Medical office space within UofL Health - Abraham Flexner Center.

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Beaumont Centre Outparcel Opportunity
    Beaumont Centre Outparcel Opportunity

    3199 Beaumont Centre Circle, Lexington, KY 40513

    Contact for pricing

    Outparcel opportunity in established shopping center for ground lease.

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    Prime Lexington Outlot Opportunity
    Prime Lexington Outlot Opportunity

    3330 Partner Place, Lexington, KY 40503

    Contact for pricing

    Outlot for ground lease or build-to-suit in South Lexington.

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    Corner Lot on Highway 72
    Corner Lot on Highway 72

    30472 Highway 72, Madison, AL 35756

    $5,000/Mo
    1,875 sqft · $32 SF/Yr

    1.7 acre corner lot zoned for commercial, medical, residential.

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    Prime Development Opportunity in Greenville
    Prime Development Opportunity in Greenville

    39 Airpark Ct, Greenville, SC 29607

    Contact for pricing

    1.27 acre interstate-visible land for ground lease or build-to-suit.

    View details

    Jefferson County, KY Medical Office Space Market Trends and Statistics

    Explore Medical Office Space leasing options in Jefferson County, KY with 11 listings featured on our commercial real estate exchange. The current inventory includes 20,637 square feet of properties with an estimated lease value of $68 SF/Yr.

    Estimated lease rates for Medical Office Space in Jefferson County, KY begin at $18 SF/Yr, with an average of $22 SF/Yr and extend to $26 SF/Yr.
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