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    Louisville, KY Medical Office Space for Lease

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    Lyndon, KY Hurstbourne, KY Hurstbourne Acres, KY Jeffersonville, IN Prospect, KY Jeff, IN Middletown, KY Jeffersontown, KY
    6 properties
    St. Matthews Class A Office
    Updated: Mar 25
    St. Matthews Class A Office

    4500 Bowling Boulevard, Louisville, KY 40207

    $26 SF/Yr
    12,710 sqft
    Prime "Plug & Play" office space available immediately with furniture included.
    Unparalleled access to downtown and the East End with convenient access to I‑64 and I‑264.
    Located in the Dupont Medical District, less than a half mile from three major hospitals.
    Lowest vacancy rate in the market.
    Abundant amenities within a mile, including restaurants, hospitality, fitness centers, and shopping.
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    Office Space Near Holiday Manor
    Updated: Nov 22, 2025
    Office Space Near Holiday Manor

    4912 U.S. 42, Louisville, KY 40222

    $25 SF/Yr
    8,385 sqft
    Excellent visibility and access
    Suites from 1,011± SF to 6,936± SF available
    Across US Hwy 22 from the new VA Hospital
    Located near the US 42 / I‑264 Interchange
    Medical and traditional office space available
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    Eastwood Mixed-Use Development Opportunity
    Eastwood Mixed-Use Development Opportunity

    16223 Shelbyville Rd, Louisville, KY 40245

    $25 SF/Yr
    124,160 sqft

    Mixed-use development near Publix with office, retail, and medical space.

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    Medical Office Suite in Office Building
    Medical Office Suite in Office Building

    4036 Dutchmans Lane, Louisville, KY 40207

    Contact for pricing
    1,800 sqft

    1,800 SF office space behind Pro Scan Imaging, formerly a home health agency, across from Norton Women’s and Children’s.

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    Downtown Louisville Medical Office Space
    Downtown Louisville Medical Office Space

    645 Roy Wilkins Ave, Louisville, KY 40203

    $15 SF/Yr

    Medical office space in Downtown Louisville's Central Business District.

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    Medical Clinic & Office Building
    Medical Clinic & Office Building

    9616 Dixie Hwy, Louisville, KY 40272

    Contact for pricing
    10,500 sqft

    Medical clinic and office building in high-traffic area.

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    Based on your search, we've compiled 23 Potential Opportunities for your consideration. Besides 6 Active listings in Louisville, KY, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 9 Properties for Sales.

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Flexible Office-Retail Space
    Flexible Office-Retail Space

    7225 Novas Lndg, Sellersburg, IN 47172

    $4,968/Mo
    4,968 sqft

    Flexible layout with large windows and ample parking, suited for office, retail, service, or medical use.

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    Finished Retail Space on Highway
    Finished Retail Space on Highway

    324-326 N Indiana Ave, Sellersburg, IN

    $15 SF/Yr
    6,350 sqft

    Finished and unfinished retail space on a high-traffic road.

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    Furnished Medical Office Space Available
    Furnished Medical Office Space Available

    4101 Technology Avenue, New Albany, IN 47150

    Contact for pricing

    Furnished medical office space for sublease in Purdue Research Park.

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    Medical Office Space in New Albany
    Medical Office Space in New Albany

    4000 Technology Ave, New Albany, IN 47150

    Contact for pricing

    Newly constructed medical office space in Purdue Research Park.

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    Similar Spaces for Sale in Louisville, KY

    Consider Similar Space for Sale. We found 9 Spaces matching your search parameters.

    Four-Unit Office Condominium
    Four-Unit Office Condominium

    3401 Stony Spring Circle, Louisville, KY 40220

    $825,000
    5,600 sqft 52.90 AC lot

    All-brick two-story office condominium with four individual suites for professional and medical uses, plus ample parking.

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    Medical Center on Healthcare Corridor
    Medical Center on Healthcare Corridor

    4730 CHAMPIONS TRACE LN, Louisville, KY 40218

    $4,565,614
    7,907 sqft

    Located on a major East Louisville medical and retail corridor with fast interstate access for outpatient and dialysis services.

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    Former JCPS Childcare Education Center
    Former JCPS Childcare Education Center

    7401 Riverport Dr, Louisville, KY 40258

    $995,000
    8,935 sqft 3.00 AC lot

    Well-maintained 8,900 SF building on 3+ acres, suitable for various uses.

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    Freestanding Medical Office in St. Matthews
    Freestanding Medical Office in St. Matthews

    217 Breckenridge Ln, Louisville, KY 40207

    $700,000
    2,183 sqft

    Two-story medical office with basement and on-site parking.

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    Medical/Office Building Near UofL Hospital
    Medical/Office Building Near UofL Hospital

    1700 Old Bluegrass Ave, Louisville, KY 40215

    $2,100,000
    21,286 sqft

    Well-located medical/office building near UofL Hospital, available for sale or lease.

    View details
    Two-Tenant Oral Surgery Investment
    Two-Tenant Oral Surgery Investment

    2800 Cannons Ln, Louisville, KY 40205

    $6,634,621
    11,787 sqft

    Two-tenant oral surgery property with a 7.22% cap rate.

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    Move-in Ready Office Condominium
    Move-in Ready Office Condominium

    1300 Gardiner Lane, Louisville, KY

    $125,000
    1.60 AC lot

    Well-maintained office condo in Gardiner Lane Professional Office Park.

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    Turnkey Dental Office Suite
    Turnkey Dental Office Suite

    3046 Breckenridge Ln, Louisville, KY 40220

    $150,000

    Well-maintained dental office suite with multiple treatment rooms and reception, located within a professional office complex.

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    Medical Office in Outpatient Center
    Medical Office in Outpatient Center

    225 Abraham Flexner Way, Louisville, KY 40202

    $595,000
    3,005 sqft

    Medical office space within UofL Health - Abraham Flexner Center.

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Lexington Outlot Opportunity
    Prime Lexington Outlot Opportunity

    3330 Partner Place, Lexington, KY 40503

    Contact for pricing

    Outlot for ground lease or build-to-suit in South Lexington.

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    Corner Lot on Highway 72
    Corner Lot on Highway 72

    30472 Highway 72, Madison, AL 35756

    $5,000/Mo
    1,875 sqft

    1.7 acre corner lot zoned for commercial, medical, residential.

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    Prime Development Opportunity in Greenville
    Prime Development Opportunity in Greenville

    39 Airpark Ct, Greenville, SC 29607

    Contact for pricing

    1.27 acre interstate-visible land for ground lease or build-to-suit.

    View details
    Office Development Land For Lease
    Office Development Land For Lease

    1323 Strawfloor Drive, Jonesboro, AR 72401

    Contact for pricing
    4,000 sqft

    2.43 acres for office development with build-to-suit opportunity.

    View details

    Louisville, KY Medical Office Space Market Trends and Statistics

    Explore Medical Office Space leasing options in Louisville, KY with 6 listings featured on our commercial real estate exchange. The current inventory includes 145,255 square feet of properties with an estimated lease value of $76 SF/Yr.

    Estimated lease rates for Medical Office Space in Louisville, KY begin at $25 SF/Yr, with an average of $25.33 SF/Yr and extend to $26 SF/Yr.
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    Most Searched ZIP Codes in Louisville, KY

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    • 40203
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