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    Jefferson County, KY Medical Office Space for Lease

    12 results
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    St. Matthews Class A Office
    $26 SF/Yr
    12,710 SF

    St. Matthews Class A Office

    4500 Bowling Boulevard, Louisville, KY 40207

    Prime office space in St. Matthews near medical district.

    • Prime "Plug & Play" office space available immediately with furniture included.
    • Unparalleled access to downtown and the East End with convenient access to I‑64 and I‑264.
    • Located in the Dupont Medical District, less than a half mile from three major hospitals.
    • Lowest vacancy rate in the market.
    • Abundant amenities within a mile, including restaurants, hospitality, fitness centers, and shopping.
    Updated: Mar 25
    View details
    Medical Office Freestanding Building
    $18 SF/Yr
    5,300 SF

    Medical Office Freestanding Building

    927 E. Broadway, Louisville, KY 40204

    5,300 SF medical office building for lease in Louisville.

    • 5,300 SF free‑standing building fully built out for medical office use.
    • Located on E. Broadway at the eastern edge of downtown Louisville, with easy access to downtown and the Highlands neighborhood.
    • NNN lease with a 60‑month initial term and renewal options.
    • Features ten exam rooms, multiple treatment areas, private offices, restrooms, storage, and a breakroom.
    • Off‑street parking available.
    Updated: Jan 26
    View details
    Medical Office Space For Rent
    $24 SF/Yr
    2,627 SF

    Medical Office Space For Rent

    Medical office space in high-traffic location near major retailers.

    9370 Cedar Center Way, Louisville, KY 40291
    View details
    Prime Commercial Space in Fern Creek
    $21 SF/Yr
    4,980 SF

    Prime Commercial Space in Fern Creek

    4980 sqft C1 zoned space available December 2025.

    5700 Bardstown Rd, Louisville, KY
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    Downtown Louisville Medical Office Space
    $15 SF/Yr

    Downtown Louisville Medical Office Space

    Medical office space in Downtown Louisville's Central Business District.

    645 Roy Wilkins Ave, Louisville, KY 40203
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    Prime Commercial Land in Jeffersontown
    Contact for pricing

    Prime Commercial Land in Jeffersontown

    High-traffic location suitable for ground lease or build-to-suit.

    9604 Taylorsville Rd, Jeffersontown, KY 40299
    View details
    Eastwood Mixed-Use Development Opportunity
    Contact for pricing
    124,160 SF

    Eastwood Mixed-Use Development Opportunity

    Mixed-use development near Publix with office, retail, and medical space.

    16223 Shelbyville Rd, Louisville, KY 40245
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    Medical Office Space For Rent
    Contact for pricing

    Medical Office Space For Rent

    Medical office space available in east Louisville near Paddock Shops.

    4201 Springhurst Blvd, Louisville, KY 40241
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    Former Dentist Office on Dixie
    Contact for pricing
    1,500 SF

    Former Dentist Office on Dixie

    Successful former dentist office with high traffic location.

    10303 Dixie Hwy, Louisville, KY 40272
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    New Mixed-Use Development, Louisville
    Contact for pricing

    New Mixed-Use Development, Louisville

    New Class A mixed-use development coming in 2026.

    1041 Zorn Ave, Louisville, KY 40207
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    Retail Space in Fern Creek
    Contact for pricing
    6,000 SF

    Retail Space in Fern Creek

    Class-A retail space in high-growth Fern Creek trade area.

    7931 Bardstown Rd, Louisville, KY 40291
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    Medical Clinic & Office Building
    Contact for pricing
    10,500 SF

    Medical Clinic & Office Building

    Medical clinic and office building in high-traffic area.

    9616 Dixie Hwy, Louisville, KY 40272
    View details
    Based on your search, we've compiled 23 Potential Opportunities for your consideration. Besides 12 Active listings in Jefferson County, KY, we suggest exploring alternatives. Similar 7 Properties for Sales.

    Explore Similar Spaces for Sale in Jefferson County, KY

    Consider Similar Space for Sale. We found 7 Spaces matching your search parameters.

    Former JCPS Childcare Education Center
    $995,000
    8,935 SF

    Former JCPS Childcare Education Center

    Well-maintained 8,900 SF building on 3+ acres, suitable for various uses.

    7401 Riverport Dr, Louisville, KY 40258
    View details
    Freestanding Medical Office in St. Matthews
    $700,000
    2,183 SF

    Freestanding Medical Office in St. Matthews

    Two-story medical office with basement and on-site parking.

    217 Breckenridge Ln, Louisville, KY 40207
    View details
    Move-in Ready Office Condominium
    $135,000
    1.60 Acres

    Move-in Ready Office Condominium

    Well-maintained office condo in Gardiner Lane Professional Office Park.

    1300 Gardiner Lane, Louisville, KY
    View details
    Shelbyville Road Commercial Opportunity
    $2,500,000
    5,566 SF

    Shelbyville Road Commercial Opportunity

    5566 SF building on 4.1 acres for sale.

    14001 Shelbyville Rd, Louisville, KY 40245
    View details
    Medical/Office Building Near UofL Hospital
    $2,300,000
    21,286 SF

    Medical/Office Building Near UofL Hospital

    Well-located medical/office building near UofL Hospital, available for sale or lease.

    1700 Old Bluegrass Ave, Louisville, KY 40215
    View details
    Two-Tenant Oral Surgery Investment
    $6,634,621
    11,787 SF

    Two-Tenant Oral Surgery Investment

    Two-tenant oral surgery property with a 7.22% cap rate.

    2800 Cannons Ln, Louisville, KY 40205
    View details
    Medical Office in Outpatient Center
    $595,000
    3,005 SF

    Medical Office in Outpatient Center

    Medical office space within UofL Health - Abraham Flexner Center.

    225 Abraham Flexner Way, Louisville, KY 40202
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Highway 72 Corner Lot
    $6,500 /Mo
    1,875 SF

    Highway 72 Corner Lot

    1.6 acre commercial lot for rent on Highway 72.

    30472 Highway 72, Madison, AL 35756
    View details
    Prime Land in Upper St Clair
    $50,000

    Prime Land in Upper St Clair

    Commercial land for lease in Upper St Clair, PA.

    2585 Maple Lane, Upper St Clair, PA 15241
    View details
    Prime Commercial Lot For Rent
    $7,500 /Mo

    Prime Commercial Lot For Rent

    0.66 acre commercial lot with high visibility.

    Tift Avenue N, Tifton, GA 31794
    View details
    Valdosta Commercial Land For Lease
    Contact for pricing
    43,560 SF

    Valdosta Commercial Land For Lease

    Prime commercial land in high-growth Valdosta corridor, suitable for various uses.

    0 Inner Perimeter Rd & Park Ave., Valdosta, GA 31602
    View details

    Jefferson County, KY Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Jefferson County, KY with 12 listings featured on our commercial real estate exchange. The current inventory includes 3,947,276,520 square feet of properties with an estimated lease value of $103 SF/Yr.

    Estimated lease rates for Medical Office Space in Jefferson County, KY begin at $14 SF/Yr, with an average of $20 SF/Yr and extend to $26 SF/Yr.
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    Medical Office Space by market

    Browse Medical Office Space for Lease Near Jefferson, KY

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