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    San Luis Obispo County, CA Medical Office Space for Lease

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    Los Angeles, CA San Diego, CA San Francisco, CA
    15 results
    Freestanding Corner Building in Pismo
    Contact for pricing
    1,175 SF

    Freestanding Corner Building in Pismo

    600 Price, Pismo Beach, CA 93449

    Freestanding corner building suitable for office, retail, or medical uses.

    • High‑visibility corner location with significant frontage on Price St (90 ft) and Hinds Ave (50 ft).
    • High traffic counts: 14,758 CPD on Price St and 82,376 CPD on El Camino Real/Hinds Ave.
    • Flexible C‑1 zoning allows for a variety of uses including office, service retail, medical, or personal services.
    • Rare freestanding building offering single‑tenant identity and prominent signage opportunities.
    • Includes private restroom, kitchenette, and multiple private offices.
    Updated: May 4
    View details
    Remodeled Office Suite For Rent
    $2,250/Mo
    930 SF

    Remodeled Office Suite For Rent

    1250 Peach St, San Luis Obispo, CA

    Remodeled office suite with mountain views in Fremont Medical Center.

    • Remodeled suite in the coveted Fremont Medical Center
    • Two offices with separate entrances
    • Deck with views of San Luis Mountain
    • Kitchenette and bathroom included
    • Ample parking available
    Updated: Sep 29, 2025
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    Freestanding Building with Parking Spaces
    Contact for pricing

    Freestanding Building with Parking Spaces

    Freestanding building with efficient layout, parking, and prominent signage.

    3565 S Higuera, San Luis Obispo, CA 93401
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    Medical Office Near Sierra Vista
    $3 SF/Yr
    1,300 SF

    Medical Office Near Sierra Vista

    Ground floor medical office space available near Sierra Vista Hospital.

    100 Casa St, San Luis Obispo, CA
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    Turn Key Medical Suite
    Contact for pricing

    Turn Key Medical Suite

    Medical suite with exam rooms, physician's office, and nurse's station.

    628 California Blvd D-1, San Luis Obispo, CA 93401
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    Ground Floor Medical Office Space
    Contact for pricing
    2,164 SF

    Ground Floor Medical Office Space

    2164 SF office space available 8/1/2026.

    880 N Oak Park Blvd 103, Arroyo Grande, CA 93420
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    Downtown San Luis Obispo Office Space
    $1.05 SF/Yr

    Downtown San Luis Obispo Office Space

    First floor office suite suitable for medical or professional use.

    990 Pacific Street |, San Luis Obispo, CA 93401
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    Class A Office Space Available
    $1.85 SF/Yr
    7,197 SF

    Class A Office Space Available

    Ground floor office suite with upgraded finishes and private patios.

    895 Aerovista Pl, San Luis Obispo, CA
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    Prime Nipomo Retail/Service Space
    Contact for pricing
    900 SF

    Prime Nipomo Retail/Service Space

    900 SF retail/service space in Nipomo's commercial corridor.

    541 W Tefft St, Nipomo, CA 93444
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    Medical Office Space Available
    $2 SF/Yr
    1,877 SF

    Medical Office Space Available

    Medical office condo for rent in established medical hub.

    325 Posada Ln, Templeton, CA
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    Arroyo Grande Office Space Available
    $1.75 SF/Yr
    1,748 SF

    Arroyo Grande Office Space Available

    Office suite with exam rooms, private restroom, and patio.

    200 Station Way, Arroyo Grande, CA
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    Renovated Medical/Dental Office Space
    $2 SF/Yr
    1,010 SF

    Renovated Medical/Dental Office Space

    Recently renovated medical/dental office space available for immediate occupancy.

    1223 Higuera St, San Luis Obispo, CA
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    Medical Office Condo Near Hospital
    Contact for pricing
    1,272 SF

    Medical Office Condo Near Hospital

    Medical office condo for lease near Twin Cities Hospital.

    1105 Las Tablas Road, Templeton, CA 93465
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    1288 Morro St, Suite 100
    $1.85 SF/Yr

    1288 Morro St, Suite 100

    Medical Office | San Luis Obispo, CA

    1288 Morro Street, Suite 100 | San Luis Obispo, CA 93401, San Luis Obispo, CA 93401
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    Prime Commercial Parcels for Lease
    Contact for pricing

    Prime Commercial Parcels for Lease

    Six improved parcels available for lease in San Luis Obispo.

    250 Tank Farm Rd, San Luis Obispo, CA 93401
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    Based on your search, we've compiled 26 Potential Opportunities for your consideration. Besides 15 Active listings in San Luis Obispo County, CA, we suggest exploring alternatives. Similar 7 Properties for Sales.

    Similar Spaces for Sale in San Luis Obispo County, CA

    Consider Similar Space for Sale. We found 7 Spaces matching your search parameters.

    Arroyo Grande Commercial Sale Opportunity
    $699,000
    1,751 SF
    Arroyo Grande Commercial Sale Opportunity

    Versatile space suitable for medical or professional office uses.

    1577 El Camino Real, Arroyo Grande, CA 93420

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    Versatile Medical/Professional Office Space
    $699,000
    Versatile Medical/Professional Office Space

    Adaptable space for medical or professional use, convenient location.

    1577 El Camino Real, Arroyo Grande, CA 93420

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    Mixed-Use Commercial Property Near Courthouse
    $1,395,000
    Mixed-Use Commercial Property Near Courthouse

    Mixed-use commercial property with flexible office space and on-site parking.

    1022 Mill St, San Luis Obispo, CA 93401

    View details
    Templeton Office Suite For Sale
    $185,000
    1,200 SF
    Templeton Office Suite For Sale

    Professional office suite in Templeton, near Twin Cities Hospital.

    1050 Las Tablas Rd 5, Templeton, CA 93465

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    Turn-Key Medical Building on Vine
    $900,000
    Turn-Key Medical Building on Vine

    Medical building near downtown Paso Robles, suitable for office uses.

    1036 Vine St, Paso Robles, CA 93446

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    Turn-Key Medical Building on Vine
    $900,000
    1,914 SF
    Turn-Key Medical Building on Vine

    Medical building near downtown Paso Robles with renovated interior.

    1036 Vine St, Paso Robles, CA 93446

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    Medical Office Condo Near Hospital
    Contact for pricing
    1,272 SF
    Medical Office Condo Near Hospital

    Medical office condo with backup power system near Twin Cities Hospital.

    1105 Road Unit E Unit E, Templeton, CA 93465

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Grand Junction Commercial Land Lease
    $9,656/Mo

    Grand Junction Commercial Land Lease

    0.74 acre commercial land for lease in Grand Junction.

    Highway 6&50, Grand Junction, CO 81505
    View details
    Grand Junction Commercial Land Opportunity
    $17,728/Mo

    Grand Junction Commercial Land Opportunity

    1.36 acre commercial land for lease in Grand Junction.

    Sanford Drive, Grand Junction, CO 81505
    View details
    El Paso Commercial Land Lease
    $3,600/Mo

    El Paso Commercial Land Lease

    Commercial land for lease in a strategic El Paso location.

    5538 E Paisano Drive, El Paso, TX 79905
    View details
    Office Development Land For Lease
    Contact for pricing
    4,000 SF

    Office Development Land For Lease

    2.43 acres for office development with build-to-suit opportunity.

    1323 Strawfloor Drive, Jonesboro, AR 72401
    View details

    San Luis Obispo County, CA Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in San Luis Obispo County, CA with 15 listings featured on our commercial real estate exchange. The current inventory includes 14,087 square feet of properties with an estimated lease value of $41 SF/Yr.

    Estimated lease rates for Medical Office Space in San Luis Obispo County, CA begin at $1.05 SF/Yr, with an average of $5 SF/Yr and extend to $29 SF/Yr.
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    Medical Office Space by market

    Browse Medical Office Space for Lease Near San Luis Obispo, CA

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