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    Salem, VA Commercial Real Estate for Sale

    27 results
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    Development Land Near Interstate 81
    $349,950
    2.67 Acres

    Development Land Near Interstate 81

    Thompson Memorial Dr, Salem, VA 24153

    2.67 acres of land suitable for development and rezoning.

    • High traffic location
    • Located right next to Interstate 81
    • 2.67 acres
    • Great for development
    • Tons of potential
    Updated: Sep 16, 2025
    View details
    Salem, VA Undeveloped Land
    $650,000
    12.45 Acres

    Salem, VA Undeveloped Land

    1000 Blk Polar Ln, Salem, VA 24153

    Undeveloped land with views, convenient to travel and dining.

    • Best location in Salem for travel and dining.
    • Beautiful site for development or retreat.
    • Enjoy views all around.
    • Quiet atmosphere.
    • Private setting.
    Updated: Sep 29, 2025
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    Salem Land with C2 Zoning
    $78,300
    5.22 Acres

    Salem Land with C2 Zoning

    5.22 acre lot with C2 zoning near Interstate 81.

    Thompson Memorial Dr, Salem, VA 24153
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    Mountaintop Property with Private Lake
    $1,449,000
    31.37 Acres

    Mountaintop Property with Private Lake

    Secluded 31.37-acre property with lake, shop, and development potential.

    5841 Twine Hollow Rd, Salem, VA 24153
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    Salem Commercial Land For Sale
    $78,300
    5.22 Acres

    Salem Commercial Land For Sale

    5.22 acre commercial land with C2 zoning near I-81.

    Thompson Memorial Dr, Salem, VA 24153
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    Commercial Land with High Visibility
    $720,000

    Commercial Land with High Visibility

    0.927 acre commercial land with easy highway access.

    142 Horner Ln, Salem, VA 24153
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    Prestonfield Building Lot Opportunity
    $399,000

    Prestonfield Building Lot Opportunity

    2.5-acre lot suitable for office or medical development.

    200 Kingsbarn Cir, Salem, VA
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    Restaurant/Retail Building on Corner Lot
    $1,595,000
    7,980 SF

    Restaurant/Retail Building on Corner Lot

    7,980 SF building on 1.26 acres, prime corner location.

    201 Electric Rd, Salem, VA 24153
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    Multi-Tenant Office Building For Sale
    $1,425,000
    7,416 SF

    Multi-Tenant Office Building For Sale

    7,500 SF multi-tenant office building on 1.44 acres.

    1618 W Main St, Salem, VA 24153
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    Industrial Land Near Interstate 81
    $850,000

    Industrial Land Near Interstate 81

    11.7 acres of industrial land near Dixie Caverns exit.

    6190 Twine Hollow Rd, Salem, VA 24153
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    Redevelopment Opportunity in Salem
    Contact for pricing
    1,104 SF

    Redevelopment Opportunity in Salem

    Hard corner in Salem's I-81 district south.

    1622 E Main St, Salem, VA 24153
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    Industrial Property with Two Buildings
    $1,295,000
    9,200 SF

    Industrial Property with Two Buildings

    Two industrial buildings totaling 9,200 SF on 1.4 acres.

    3718 Garman Rd, Salem, VA 24153
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    Retail Property with Highway Access
    Contact for pricing
    10,545 SF

    Retail Property with Highway Access

    Retail property featuring strategic location, high traffic, and ample parking.

    1650 Braeburn Dr, Salem, VA 24153
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    Commercial Corner Lot Near Hospital
    $149,900
    1 SF

    Commercial Corner Lot Near Hospital

    Prime commercial corner lot across from Salem VA Medical Center.

    2145 Roanoke Blvd, Salem, VA 24153
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    Commercial Land Ready For Rezoning
    Contact for pricing

    Commercial Land Ready For Rezoning

    Three lots totaling 1.62 acres, prime for commercial rezoning.

    1260 Highland Rd, Salem, VA 24153
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    Salem Commercial Land For Sale
    Contact for pricing

    Salem Commercial Land For Sale

    Commercial land with high visibility and development potential.

    113 Corporate Blvd, Salem, VA
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    Keagy Road Commercial Land Lot
    Contact for pricing

    Keagy Road Commercial Land Lot

    Commercial land lot suitable for office or medical building.

    3525 Keagy Rd, Salem, VA 24153
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    Commercial Land For Sale
    Contact for pricing

    Commercial Land For Sale

    0.56 AC lot ideal for retail, restaurant, or office.

    2005 E Main St, Salem, VA 24153
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    Commercial Land on Main Street
    Contact for pricing

    Commercial Land on Main Street

    Commercial land available on high-traffic Main Street.

    922 W Main St, Salem, VA 24153
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    Retail Property in Salem, Virginia
    Contact for pricing
    176,806 SF

    Retail Property in Salem, Virginia

    Large retail property available for sale in Salem, Virginia.

    1439 W Kimball St, Salem, VA
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    Retail and Residential Investment Opportunity
    $318,500
    3,552 SF

    Retail and Residential Investment Opportunity

    3,552 SF building with retail and residential tenants.

    2263 Catawba Valley Dr, Salem, VA 24153
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    Roanoke County Industrial Development Site
    $1,150,000
    30 SF

    Roanoke County Industrial Development Site

    30.5 acres zoned I-2, suitable for large industrial development.

    5832 West River Rd, Salem, VA 24153
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    Salem Industrial Distribution Center
    $850,000

    Salem Industrial Distribution Center

    11.7-Acre I2-C Zoned Distribution Facility

    6190 Twine Hollow Rd, Salem, VA 24153
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    Prime Salem Restaurant Space
    $2,350,000
    10,545 SF

    Prime Salem Restaurant Space

    10,545 SF Restaurant, High Traffic Area

    1650 Braeburn Dr, Salem, VA 24153
    View details

    Salem, VA Commercial Real Estate Investment Opportunities Market Analysis

    Explore 27 commercial real estate for sale in Salem, VA, showcased through 27 active listings on our real estate platform. These investment opportunities span a total of 3,868,999 square feet of properties for sale, with an estimated market value of $6,105,550.

    Sale prices for business properties in Salem, VA start at $78,300, averaging $872,221, and reaching up to $2,350,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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