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    Murphysboro, IL Commercial Real Estate for Sale

    12 results
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    Historic Murphysboro Event Center
    $650,000
    0.18 Acres

    Historic Murphysboro Event Center

    1329 Walnut St, Murphysboro, IL 62966

    Historic event center and gaming facility in downtown Murphysboro.

    • Turnkey gaming facility and event center (Rosie's Gaming) with business included
    • Historic landmark building ("Old Elks Building") with a grand ballroom and capacity for up to 500 guests
    • Versatile spaces including a lounge, full bar, renovated Great Hall, and kitchens
    • Potential for adaptive reuse as a banquet hall, performance venue, gallery, conference space, or mixed‑use development
    • Prime downtown Murphysboro location
    Updated: Nov 24, 2025
    View details
    Murphysboro Multi-Story Brick Building
    $150,000
    0.28 Acres

    Murphysboro Multi-Story Brick Building

    1501 Pine St, Murphysboro, IL 62966

    14,000 sq ft multi-story building in Murphysboro, Illinois.

    • 14,000 sq ft multi‑story brick building offering generous interior space.
    • Located in the heart of Murphysboro on a corner lot.
    • Suitable for various uses: congregation, nonprofit, daycare, events, or redevelopment (subject to approval).
    • Includes two parcels dedicated to paved parking across the street.
    • Features large gathering areas, offices, classrooms, restrooms, and a kitchen.
    Updated: Nov 13, 2025
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    Commercial Land on High-Traffic Highway
    $450,000

    Commercial Land on High-Traffic Highway

    Commercial land suitable for retail, restaurant, hotel, and more.

    Country Club Rd, Murphysboro, IL 62966
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    Mixed-Use Investment Opportunity
    $525,000
    6.16 Acres

    Mixed-Use Investment Opportunity

    Income-generating property with apartments, storage units, and RV/boat parking.

    10543 State Hwy, Murphysboro, IL 62966
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    Murphysboro Duplex Investment
    $123,900
    2,016 SF

    Murphysboro Duplex Investment

    Two-unit rental property, great income potential.

    2202 Illinois Ave, Murphysboro, IL 62966
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    Murphysboro Commercial Land - 15 Acres
    $900,000
    15.89 Acres

    Murphysboro Commercial Land - 15 Acres

    High-visibility commercial land, prime Murphysboro location.

    Birkner Ln, Murphysboro, IL 62966
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    Prime Murphysboro Retail Space
    $635,000
    0.84 Acres

    Prime Murphysboro Retail Space

    7,000 SF Retail/Warehouse, $635K

    60 Niemann Ln, Murphysboro, IL 62966
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    Prime Murphysboro Retail Space
    $635,000
    7,000 SF

    Prime Murphysboro Retail Space

    7,000 SF Retail/Warehouse, High Visibility

    60 Niemann Ln, Murphysboro, IL 62966
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    Murphysboro Commercial Warehouse Opportunity
    $350,000

    Murphysboro Commercial Warehouse Opportunity

    Prime Murphysboro location, high visibility, 10,780 sq ft.

    535 14Th St, Murphysboro, IL 62966
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    Murphysboro Commercial Building - Huge Potential
    $59,900
    3,200 SF

    Murphysboro Commercial Building - Huge Potential

    3200 sq ft, two entrances, needs TLC. Great price!

    1012 14Th St, Murphysboro, IL 62966
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    Murphysboro Commercial Trio - Prime Location
    $154,900

    Murphysboro Commercial Trio - Prime Location

    Three Buildings, Endless Potential, High Traffic

    418 14Th St, Murphysboro, IL 62966
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    Murphysboro Office Building Investment
    $169,900

    Murphysboro Office Building Investment

    Prime Office w/ Rental Income

    1000 Hanson St, Murphysboro, IL 62966
    View details
    Based on your search, we've compiled 16 Potential Opportunities for your consideration. Besides 12 Active listings in Murphysboro, IL, we suggest exploring several alternatives: 4 properties in Nearby Cities

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Carbondale Flex Space - $249,900
    $249,900

    Carbondale Flex Space - $249,900

    Updated Commercial Building, Excellent Location

    1001 Beadle Dr, Carbondale, IL 62901
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    Remodeled Office Space For Sale
    $249,900
    0.14 Acres

    Remodeled Office Space For Sale

    Remodeled office space in Carbondale, perfect for medical or general use.

    1001 N Beadle Dr, Carbondale, IL 62901
    View details
    De Soto, IL Mobile Home Park Investment
    $95,000

    De Soto, IL Mobile Home Park Investment

    High-cash-flow 8-unit mobile home park in Illinois.

    101 Poplar St, De Soto, IL 62924
    View details
    96-Acre Estate with Income Potential
    $699,000
    96.61 Acres

    96-Acre Estate with Income Potential

    96.61-acre estate featuring tillable ground, hunting, and comfortable home.

    53 Private Rd, De Soto, IL 62924
    View details

    Murphysboro, IL Commercial Real Estate Investment Opportunities Market Analysis

    Explore 12 commercial real estate for sale in Murphysboro, IL, showcased through 12 active listings on our real estate platform. These investment opportunities span a total of 1,053,716 square feet of properties for sale, with an estimated market value of $3,495,000.

    Sale prices for business properties in Murphysboro, IL start at $150,000, averaging $582,500, and reaching up to $900,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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