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Waltham Life Science Conversion Project
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21 Hickory Drive, Waltham, MA 02451

Class A life science space for rent in Waltham, MA.

Space SizeContact for details
Days on Market264

Property Features for 21 Hickory Drive

General Information

Standard status Active
Property subtype Office
Listing Agency: CBRE | Boston
Listed By: Eric Smith
Source: Cbre
Added: Nov 22, 2025 Changed: Aug 10 Last Checked: Aug 12 at 11:30AM

Displayed information is deemed reliable but is not guaranteed and should be independently verified. All listing content including descriptions, pricing, images are the copyrighted material of CBRE | Boston

Investment Insights

Based on property information with market context.

GENESIS 21 Hickory is a Class A life science conversion project situated in Waltham's established life science corridor. The property, located at 21 Hickory Drive, Waltham, MA, 02451, recently underwent a full conversion from office to life science use, including main infrastructure upgrades. The GENESIS spec program will be implemented at the project, catering to the expanding market with speed to occupancy. The property is located in the premier suburban Boston market of Waltham, MA, directly along Route 128, approximately one mile south of the Waltham Woods and Bay Colony office parks. The site's location has visibility along Route 128 and offers convenient access to the Mass Pike. The property size is 24057 square feet.

Key Highlights

  • Class A life science conversion project.
  • Located in Waltham's established life science corridor.
  • Recent full conversion from office to life science use with infrastructure upgrades.

Property Analytics

Current Use

Naveris Corporate Office Meditech (Bike/Boat/Book/etc) Store Electric Vehicle Charging ... Electric Vehicle Charging Station Immunitas Therapeutics Corporate Office

Suggested Use

Top Pick Real Estate Agency Auto Parts Store Auto Repair Shop Grocery & Convenience Store Cafe & Coffee Shop Big Box & Wholesale Store

Score = modeled unmet demand for each use within ~1 mi (higher = bigger opportunity). Zoning and permitted uses should be independently verified with local authorities.

Lease Details

NNN (Triple Net)
Lease Type

Location Intelligence

Trade Area within ½ mile

1,113
Businesses Nearby

Demographics for 02451, MA

17,953
Population
7,852
Households
2.3
Avg Household Size
39
Median Age
55%
College-Educated
93%
High-School Grad
5.3 sq mi
ZIP Area
3,387
Density / Sq Mi
$119,509
Median Household Income
$66,318
Median Earnings
$2,537
Median Rent
$709,200
Median Home Value

Market

Vacancy Rate% for Office in Northeast region

13.1% 2019
15.4% 2020
17.6% 2021
19.1% 2022
20.2% 2023
20.9% 2024
19.9% 2025
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Frequently Asked Questions

What type of property is this?
Office building - Class A life science space for rent in Waltham, MA.
Where is this office building located?
The property is located at 21 Hickory Drive Waltham, MA.
What are key features of this property?
This property features: Class A life science conversion project.; Located in Waltham's established life science corridor.; Recent full conversion from office to life science use with infrastructure upgrades.
More about this property
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