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    Santee, SC Commercial Real Estate for Sale

    11 results
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    Highway Commercial Property with Storage
    $1,900,000
    3,282 SF

    Highway Commercial Property with Storage

    9158 Old Number Six Hwy, Santee, SC 29142

    Commercial building with storage units near I-95 in Santee.

    • High visibility location near Highway 6 and I‑95.
    • Commercial property designed for two separate businesses.
    • 22 storage units at the rear of the property currently rented.
    • Second story suitable for offices or storage.
    • Located near Somerset homes and across from Santee‑Cooper Resort entrance.
    Updated: Nov 13, 2025
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    Prime Santee Land Opportunity
    $1,500,000
    18.17 Acres

    Prime Santee Land Opportunity

    301 & 15 Hwy, Santee, SC 29142

    Highly visible 18-acre corner tract near I-95 in Santee, SC.

    • Highly visible 18‑acre corner tract at the intersection of Highways 301 and 15, offering outstanding exposure.
    • Located just off I‑95 (Exit 97) in Santee, SC, providing easy access to major transportation routes.
    • Proximity to Lake Marion recreation and golf courses, enhancing the area's appeal.
    • Comprised of five contiguous parcels, offering flexibility for development.
    • Primarily open and tillable land with minimal wooded area, simplifying development.
    Updated: Feb 2
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    Prime Corner Lot in Santee
    $1,950,000
    22.04 Acres

    Prime Corner Lot in Santee

    Highly visible acreage near I-95, ideal for development.

    15 And 301, Santee, SC 29142
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    Santee Cooper Resort Land
    $85,000
    0.48 Acres

    Santee Cooper Resort Land

    Gated golf community lot near Lake Marion.

    128 Cooper Cir, Santee, SC 29142
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    Santee Cooper Resort Land
    $85,000
    0.54 Acres

    Santee Cooper Resort Land

    Land in gated golf community near Lake Marion.

    110 Cooper Dr, Santee, SC 29142
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    Land in Established Santee Community
    $150,000
    5.00 Acres

    Land in Established Santee Community

    5-acre land parcel in an established Santee, SC community.

    Ellexlee Rd, Santee, SC 29142
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    Land Near Santee Development Ready
    Pending
    $189,900
    21.00 Acres

    Land Near Santee Development Ready

    21 acre tract near Santee, SC, suitable for development.

    Graveyard Rock Rd, Santee, SC 29142
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    Prime Commercial Land Near I-95
    $339,000

    Prime Commercial Land Near I-95

    Shovel-ready land near I-95, ideal for retail development.

    676 Bass Dr, Santee, SC 29142
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    Santee Commercial Land Near I-95
    $339,000
    4 SF

    Santee Commercial Land Near I-95

    4.65 acres of commercial land near I-95 in Santee, SC.

    656 Bass Dr, Santee, SC 29142
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    Commercial Land Near I-95
    $705,000

    Commercial Land Near I-95

    Shovel-ready commercial land in high-traffic area near I-95.

    301 Bass Drive/Hwy, Santee, SC
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    Freestanding Retail Property For Sale
    Contact for pricing
    9,993 SF

    Freestanding Retail Property For Sale

    Freestanding retail property with investment-grade tenant Dollar Tree.

    100 Bass Dr, Santee, SC 29142
    View details
    Based on your search, we've compiled 15 Potential Opportunities for your consideration. Besides 11 Active listings in Santee, SC, we suggest exploring several alternatives: 4 properties in Nearby Cities

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Downtown Elloree Commercial Gem
    $475,000
    6,060 SF

    Downtown Elloree Commercial Gem

    Retail, Apartments, High Traffic Location

    2701 Cleveland St, Elloree, SC 29047
    View details
    Historic Elloree Event Venue
    $175,000
    1,600 SF

    Historic Elloree Event Venue

    Income-producing event venue in historic Elloree, South Carolina.

    2725 Cleveland St, Elloree, SC 29047
    View details
    Cleared Commercial Land For Sale
    Contact for pricing

    Cleared Commercial Land For Sale

    1.41 AC corner parcel near I-26 & I-95.

    2718 Old State Rd, Cameron, SC 29030
    View details
    Cleared Commercial Land For Sale
    Contact for pricing

    Cleared Commercial Land For Sale

    3.88 AC of cleared commercial land near major roads.

    2710 Old State Rd, Cameron, SC 29030
    View details

    Santee, SC Commercial Real Estate Investment Opportunities Market Analysis

    Explore 11 commercial real estate for sale in Santee, SC, showcased through 11 active listings on our real estate platform. These investment opportunities span a total of 2,972,099 square feet of properties for sale, with an estimated market value of $5,859,900.

    Sale prices for business properties in Santee, SC start at $85,000, averaging $837,128, and reaching up to $1,950,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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