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    Seneca, MO Commercial Real Estate for Sale

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    Saint Louis, MO Kansas City, MO Louis, MO
    9 results
    Versatile Commercial Property in Seneca
    $199,999
    1.10 Acres

    Versatile Commercial Property in Seneca

    419 Washington Avenue, Seneca, MO 64865

    Two shop buildings totaling over 5,000 sq ft on 1.1 acres.

    • Two buildings totaling over 5,000 sq ft of functional space on 1.1 +/- acres.
    • Located within city limits, minutes from Downstream Casino Resort and Joplin, benefiting from strong regional traffic.
    • Versatile property suitable for mechanic shop, warehouse, service‑based business, or commercial investment.
    • First building: 2,400 sq ft shop with storefront windows and three garage doors.
    • Second building: 2,800 sq ft workshop with two garage doors.
    Updated: Apr 7
    View details
    Seneca Commercial Property for Sale
    $169,900
    1,737 SF

    Seneca Commercial Property for Sale

    1418 Cherokee Avenue, Seneca, MO 64865

    Commercial property in Seneca, Missouri, suitable for various business ventures.

    • High‑visibility corner lot location directly in front of the Seneca Fire Department.
    • Commercial zoning suitable for a business (currently a tattoo shop) or residential use.
    • Carport and off‑street parking available.
    • Convenient access to nearby restaurants and grocery stores.
    • Features a wonderful front porch.
    Updated: Dec 21, 2025
    View details
    Turnkey Brewery and Restaurant Space
    $240,000
    6,593 SF

    Turnkey Brewery and Restaurant Space

    Fully equipped brewery and restaurant in historic downtown Seneca.

    1107 Cherokee Avenue, Seneca, MO 64865
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    Seneca, MO Land For Sale
    $315,000
    45.00 Acres

    Seneca, MO Land For Sale

    45 acres of land suitable for commercial or residential development.

    Hwy 60, Seneca, MO 64865
    View details
    Seneca Mixed-Use Property For Sale
    $109,327
    2,871 SF

    Seneca Mixed-Use Property For Sale

    Remodeled living quarters attached to a historic commercial building.

    121 Washington Avenue, Seneca, MO 64865
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    82.2 Acre Farm Near Town
    $449,900
    82.00 Acres

    82.2 Acre Farm Near Town

    82.2 acre farm suitable for livestock and hunting.

    Woodland Drive, Seneca, MO 64865
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    Downtown Seneca Commercial Opportunity
    $67,500

    Downtown Seneca Commercial Opportunity

    Commercial building on Main Street in downtown Seneca, Missouri.

    1117 Cherokee Avenue, Seneca, MO 64865
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    Downtown Seneca Corner Lot Retail
    $79,900

    Downtown Seneca Corner Lot Retail

    Highly visible corner lot in Downtown Seneca with great potential.

    1320 Cherokee Avenue, Seneca, MO 64865
    View details
    Restaurant/Bar Opportunity with Equipment Included
    $149,960

    Restaurant/Bar Opportunity with Equipment Included

    Restaurant/bar/grill opportunity with equipment and fixtures included.

    Cherokee Avenue, Seneca, MO 64865
    View details
    Based on your search, we've compiled 153 Potential Opportunities for your consideration. Besides 9 Active listings in Seneca, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 140 Off-Market properties to explore as potential leads

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    High Visibility Commercial Land
    $299,000
    3.00 Acres

    High Visibility Commercial Land

    Prime commercial land with exceptional I-44 visibility and access.

    I44 and Greenwood Drive unit: 5-6, Joplin, MO 64804
    View details
    High Visibility Land on I-44
    $299,000
    3.00 Acres

    High Visibility Land on I-44

    3-acre commercial land with high I-44 visibility.

    I44 and Greenwood Drive unit: 3-4, Joplin, MO 64804
    View details
    101.5 Acre Parcel For Sale
    $812,000
    4,421,340 SF

    101.5 Acre Parcel For Sale

    101.5 acre parcel suitable for development, grazing, or crops.

    11818 Nettle Drive, Neosho, MO 64850
    View details
    101.5 Acres Near Highway 60
    $812,000
    101.00 Acres

    101.5 Acres Near Highway 60

    101.5 acre parcel near Hwy 60 in Neosho, Missouri.

    11818 Nettle Drive, Neosho, MO 64850
    View details

    Explore Off-Market Properties in Seneca, MO

    Consider similar Off-Market properties in Seneca, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    1107 Cherokee Ave

    1107 Cherokee Ave

    RETAIL STORES (PERSONAL SERVICES) • 6,559 SF
    Value Estimation by Request
    1107 Cherokee Ave, Seneca, MO 64865-9207
    View details
    Seneca, MO 64865

    Seneca, MO 64865

    OFFICE BUILDING • 376 SF
    Value Estimation by Request
    Seneca, MO 64865
    View details
    1124 Cherokee Ave

    1124 Cherokee Ave

    RETAIL STORES (PERSONAL SERVICES) • 5,101 SF
    Value Estimation by Request
    1124 Cherokee Ave, Seneca, MO 64865-9207
    View details
    1038 Cherokee Ave

    1038 Cherokee Ave

    RETAIL STORES (PERSONAL SERVICES) • 4,773 SF
    Value Estimation by Request
    1038 Cherokee Ave, Seneca, MO 64865-9206
    View details
    1320 Cherokee Ave

    1320 Cherokee Ave

    OFFICE BUILDING • 2,149 SF
    Value Estimation by Request
    1320 Cherokee Ave, Seneca, MO 64865-8682
    View details
    Seneca, MO 64865

    Seneca, MO 64865

    RETAIL STORES (PERSONAL SERVICES) • 2,027 SF
    Value Estimation by Request
    Seneca, MO 64865
    View details
    9911 Hwy 43

    9911 Hwy 43

    RETAIL STORES (PERSONAL SERVICES) • 3,677 SF
    Value Estimation
    $560,000
    9911 Hwy 43, Seneca, MO 64865-8388
    View details
    1117 Cherokee Ave

    1117 Cherokee Ave

    OFFICE BUILDING • 3,228 SF
    Value Estimation by Request
    1117 Cherokee Ave, Seneca, MO 64865-9207
    View details
    Seneca, MO 64865

    Seneca, MO 64865

    COMMERCIAL (GENERAL) • 0.55 Acres
    Value Estimation by Request
    Seneca, MO 64865
    View details
    1116 Cherokee Ave

    1116 Cherokee Ave

    RETAIL STORES (PERSONAL SERVICES) • 1,216 SF
    Value Estimation by Request
    1116 Cherokee Ave, Seneca, MO 64865-9207
    View details
    5259 State Hwy 43

    5259 State Hwy 43

    COMMERCIAL (GENERAL) • 2,926 SF
    Value Estimation by Request
    5259 State Hwy 43, Seneca, MO 64865-8692
    View details
    1123 1125th Cherokee

    1123 1125th Cherokee

    RETAIL STORES (PERSONAL SERVICES) • 1,702 SF
    Value Estimation by Request
    1123 1125th Cherokee, Seneca, MO 64865
    View details
    2179 Rya Ln

    2179 Rya Ln

    OFFICE BUILDING • 240 SF
    Value Estimation by Request
    2179 Rya Ln, Seneca, MO 64865-5201
    View details
    Seneca, MO 64865

    Seneca, MO 64865

    RETAIL STORES (PERSONAL SERVICES) • 1,700 SF
    Value Estimation by Request
    Seneca, MO 64865
    View details
    2314 Cherokee Ave

    2314 Cherokee Ave

    RESTAURANT • 2,016 SF
    Value Estimation by Request
    2314 Cherokee Ave, Seneca, MO 64865-9703
    View details

    Seneca, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 149 commercial real estate for sale in Seneca, MO, showcased through 9 active listings on our real estate platform. These investment opportunities span a total of 5,803,063 square feet of properties for sale, with an estimated market value of $1,725,126.

    Sale prices for business properties in Seneca, MO start at $106,000, averaging $215,640, and reaching up to $449,900 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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