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    Hillsboro, MO Commercial Real Estate for Sale

    14 results
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    Hillsboro Land Near City Hall
    $426,900
    0.51 Acres

    Hillsboro Land Near City Hall

    114 Main St, Hillsboro, MO 63050

    Versatile half-acre lot in prime Hillsboro location.

    • Prime location across from City Hall and one block from the courthouse.
    • Versatile property ideal for professional offices (attorneys, consultants, etc.).
    • Spacious half‑acre lot allows for future expansion or new construction.
    • High visibility and easy access in a bustling downtown area.
    • Recently updated with a functional kitchen area.
    Updated: Nov 11, 2025
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    Hillsboro Church with Conversion Potential
    $1,750,000
    5.00 Acres

    Hillsboro Church with Conversion Potential

    4770 State Road B, Hillsboro, MO 63050

    Church building on 5 acres, suitable for office conversion.

    • Built in 2019 (New Construction)
    • Includes a separate house at the end of the lot
    • Versatile space suitable for conversion to office or other uses
    • Basement with 10‑foot ceilings
    • Basement kitchen
    Updated: Feb 23
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    Hillsboro Mixed-Use Redevelopment Opportunity
    $450,000
    6,090 SF

    Hillsboro Mixed-Use Redevelopment Opportunity

    Versatile 6-acre property with highway frontage and redevelopment potential.

    9637 Old State Route 21, Hillsboro, MO 63050
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    Commercial Land on Corner Lot
    $350,000
    0.98 Acres

    Commercial Land on Corner Lot

    Corner lot with high visibility near highways in Hillsboro, MO.

    10865 Business 21, Hillsboro, MO 63050
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    Hillsboro Prime Location Property
    $426,900
    2,772 SF

    Hillsboro Prime Location Property

    Versatile property in prime Hillsboro location, ideal for offices.

    114 Main St, Hillsboro, MO 63050
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    Jefferson County Acreage for Sale
    $770,000
    45.29 Acres

    Jefferson County Acreage for Sale

    45+ acres in Jefferson County, Missouri, ideal for development.

    Butcher Branch Rd, Hillsboro, MO 63050
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    Hillsboro Retail with Highway Frontage
    $299,000
    0.27 Acres

    Hillsboro Retail with Highway Frontage

    Retail property in Hillsboro with highway frontage and recent updates.

    10550 Business 21, Hillsboro, MO 63050
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    Prime Hillsboro Office Building
    $437,000
    2,772 SF

    Prime Hillsboro Office Building

    Historic Charm, Modern Updates, High Visibility

    114 Main St, Hillsboro, MO 63050
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    Commercial Land For Sale
    Contact for pricing

    Commercial Land For Sale

    43 Acres zoned CC2 with high visibility and frontage.

    8719 Old State Route 21, Hillsboro, MO 63050
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    Hillsboro Retail Property for Sale
    $2,200,000
    9,641 SF

    Hillsboro Retail Property for Sale

    9,641 SF retail property available in Hillsboro, Missouri.

    10333 Business 21, Hillsboro, MO 63050
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    Hillsboro Commercial Property - Main Street
    $437,000
    0.51 Acres

    Hillsboro Commercial Property - Main Street

    Versatile Property, Prime Location, High Visibility

    114 Main St, Hillsboro, MO 63050
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    Hillsboro Commercial Investment Opportunity
    $399,900
    0.25 Acres

    Hillsboro Commercial Investment Opportunity

    Fully Leased, Multi-Tenant Building, Great ROI

    304 Locust St, Hillsboro, MO 63050
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    Historic Hillsboro Commercial Gem
    $330,000
    0.30 Acres

    Historic Hillsboro Commercial Gem

    Multi-use building, prime downtown location.

    411 Maple St, Hillsboro, MO 63050
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    Prime Hillsboro Land - 66 Acres
    $599,000
    66.00 Acres

    Prime Hillsboro Land - 66 Acres

    Missouri Farmland Investment Opportunity

    10401 Hwy Rd, Hillsboro, MO 63050
    View details
    Based on your search, we've compiled 18 Potential Opportunities for your consideration. Besides 14 Active listings in Hillsboro, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    De Soto Church Building on 5+ Acres
    $399,900
    3,739 SF

    De Soto Church Building on 5+ Acres

    Church building with spacious sanctuary and high-visibility location.

    4041 Maple Downs Ct, De Soto, MO 63020
    View details
    Festus Land with Builder Potential
    $150,300
    10.02 Acres

    Festus Land with Builder Potential

    10.02 acre lot perfect for countryside living near St. Louis.

    22 Hematite Farms Rd, Festus, MO 63028
    View details
    Historic Mixed-Use Commercial Property
    $219,000
    4,095 SF

    Historic Mixed-Use Commercial Property

    Unique 4,095 SF commercial property in downtown De Soto.

    400 N 3Rd St, De Soto, MO 63020
    View details
    Versatile Office Warehouse on 3.95 Acres
    $1,500,000
    3.94 Acres

    Versatile Office Warehouse on 3.95 Acres

    Office warehouse with endless potential in a prime location.

    620 Horine Rd, Festus, MO 63028
    View details

    Hillsboro, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 14 commercial real estate for sale in Hillsboro, MO, showcased through 14 active listings on our real estate platform. These investment opportunities span a total of 5,467,216 square feet of properties for sale, with an estimated market value of $6,248,800.

    Sale prices for business properties in Hillsboro, MO start at $299,000, averaging $568,072, and reaching up to $1,750,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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