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    St Lucie County, FL Commercial Real Estate for Sale

    919 results
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    Manufacturing Business with Real Estate
    $1,300,000

    Manufacturing Business with Real Estate

    0000 Us Highway 1, Fort Pierce, FL 34951

    Profitable manufacturing business with real estate option in Fort Pierce.

    • Established, profitable manufacturing business with consistent performance.
    • Optional real estate purchase: Over 4 acres with room for future expansion.
    • Turn‑key operation with significant upside potential.
    • Business‑only option available with NNN lease.
    • Combined business and real estate purchase available.
    Updated: Jun 10, 2025
    View details
    Established Smoke Shop For Sale
    $224,000
    1,050 SF

    Established Smoke Shop For Sale

    914 SW Gatlin Blvd, Port Saint Lucie, FL 34953

    Successful smoke shop with inventory in a prime location.

    • Established smoke shop business with a 13+ year history at this location.
    • Full inventory included in the sale.
    • Favorable lease term extending to April 30, 2028.
    • Located in a great location.
    • Central heating and central air conditioning.
    Updated: Nov 13, 2025
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    Port St. Lucie Portfolio Opportunity
    $1,500,000
    0.55 Acres

    Port St. Lucie Portfolio Opportunity

    Two adjacent income-producing commercial/residential properties in a high-growth area.

    1892 SW Biltmore St, Port Saint Lucie, FL 34984
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    Turnkey Restaurant Inside Hotel
    $175,000

    Turnkey Restaurant Inside Hotel

    Fully equipped restaurant with private entry and owner financing.

    3224 S Us Highway 1, Fort Pierce, FL 34982
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    Fort Pierce Retail Investment Opportunity
    $1,699,000

    Fort Pierce Retail Investment Opportunity

    Net lease retail investment with national brand tenant.

    2402 S Us Highway 1, Fort Pierce, FL 34982
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    US-1 Frontage Commercial Lot
    Pending
    $999,888
    0.79 Acres

    US-1 Frontage Commercial Lot

    Commercial lot with high traffic frontage on US-1.

    10720 S Us Highway 1, Port St Lucie, FL 34952
    View details
    Professional Office Space Near Downtown
    $299,999
    1,692 SF

    Professional Office Space Near Downtown

    Well-maintained office space near downtown and the Indian River.

    212 S 7Th St, Fort Pierce, FL 34950
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    US Hwy 1 Frontage Opportunity
    $125,000
    0.21 Acres

    US Hwy 1 Frontage Opportunity

    Prime commercial lot with US Hwy 1 frontage in Fort Pierce.

    4022 N Us Highway 1, Fort Pierce, FL 34946
    View details
    Medical Office in Excellent Condition
    $499,000
    0.02 Acres

    Medical Office in Excellent Condition

    Well-located medical office with five exam rooms and ample space.

    439 NW Prima Vista Blvd, Port St Lucie, FL 34983
    View details
    Commercial Property on US 1
    Pending
    $899,999
    0.73 Acres

    Commercial Property on US 1

    Commercial property on US 1 with high visibility for business.

    5989 S Us Highway 1, Fort Pierce, FL 34982
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    Port St Lucie Industrial Duplex
    $2,895,000
    0.92 Acres

    Port St Lucie Industrial Duplex

    Fully leased, renovated industrial duplex near major highways.

    1725-1733 SW Biltmore St, Port St Lucie, FL 34984
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    Turnkey Hair Salon Opportunity
    $59,000
    1,000 SF

    Turnkey Hair Salon Opportunity

    Fully equipped hair salon with strong client base for sale.

    6969 Hancock Dr, Fort Pierce, FL 34952
    View details
    Profitable Jamaican Restaurant Opportunity
    $125,000

    Profitable Jamaican Restaurant Opportunity

    Turn-key Jamaican restaurant for sale in Port St. Lucie.

    3453 SW Darwin Blvd, Port St Lucie, FL 34953
    View details
    Turn-Key Commercial Condo in St. Lucie
    $1,300,000
    4,458 SF

    Turn-Key Commercial Condo in St. Lucie

    4500+ SF commercial condo in St. Lucie West.

    266 NW Peacock Blvd, Port Saint Lucie, FL 34986
    View details
    Gas Station, Car Wash, Workshop
    $1,600,000

    Gas Station, Car Wash, Workshop

    Turnkey gas station, car wash, and mechanic shop in Florida.

    2780 SE Morningside Blvd, Port Saint Lucie, FL 34952
    View details
    Fort Pierce Commercial Property on Orange
    $399,900
    1,764 SF

    Fort Pierce Commercial Property on Orange

    Commercial property with frontage on Orange Avenue in Fort Pierce.

    2007 Orange Ave, Fort Pierce, FL 34950
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    Established Manufacturing Business on 4+ Acres
    $2,500,000
    4.20 Acres

    Established Manufacturing Business on 4+ Acres

    Successful manufacturing business with room for expansion on US #1.

    0000 Us Highway 1, Fort Pierce, FL 34951
    View details
    Established Retail Business Opportunity
    $225,000

    Established Retail Business Opportunity

    Profitable appliance parts business for sale in busy location.

    8025 S Hwy 1 U.S, Port Saint Lucie, FL 34952
    View details
    Medical Office Near Lawnwood Center
    $725,000
    2,100 SF

    Medical Office Near Lawnwood Center

    2,100 SF medical office building near Lawnwood Medical Center.

    1900 Nebraska Ave, Fort Pierce, FL 34950
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    Commercial Property Near US #1
    $2,250,000
    4.40 Acres

    Commercial Property Near US #1

    Commercial property with shop building and CBS home near US #1.

    392 E Midway Rd, Fort Pierce, FL 34982
    View details
    Established Carpet Cleaning Business Opportunity
    $250,000

    Established Carpet Cleaning Business Opportunity

    Profitable carpet cleaning business with strong market presence in Florida.

    Carpet Cleaning Way, Port Saint Lucie, FL 34987
    View details
    Established Dry-Cleaning Business For Sale
    $950,000
    2,200 SF

    Established Dry-Cleaning Business For Sale

    Profitable eco-friendly dry-cleaning business with loyal customer base in Port St. Lucie.

    123 SW Main St, Fort Pierce, FL 34953
    View details
    Medical Marijuana Business Opportunity
    $165,000
    1,816 SF

    Medical Marijuana Business Opportunity

    Established medical marijuana card clinic with recurring clients for sale.

    Port St Lucie, FL 34953
    View details
    New Industrial Distribution Facility
    $16,375,000
    188,000 SF

    New Industrial Distribution Facility

    Class A industrial distribution facility available Q1 2025.

    White Rd, Fort Pierce, FL 34945
    View details

    St Lucie County, FL Commercial Real Estate Investment Opportunities Market Analysis

    Explore 4935 commercial real estate investment opportunities in St Lucie County, FL with 919 listings featured on our commercial real estate marketplace. The current inventory includes 5,310,361,750 square feet of properties with an estimated value of $3,773,159,112.

    Estimated prices for commercial real estate in St Lucie County, FL begin at $34,000, with an average of $1,207,410 and extend to $27,600,000.

    In St Lucie County, FL, current investment values show:

    • Industrial properties positioned at $1,092,978
    • Office Properties & Spaces measuring $802,837
    • Other industrial properties assessed at $653,630
    • Retail properties calculated at $1,350,677
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    Browse Commercial real estate for Sale Near St Lucie, FL

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