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    Mayo, FL Commercial Real Estate for Sale

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    Lehigh Acres, FL Cape Coral, FL Port Charlotte, FL
    9 results
    Childcare Facility in Mayo, Florida
    $385,000
    3,044 SF

    Childcare Facility in Mayo, Florida

    311 NE CRAWFORD ST, Mayo, FL 32066

    Established childcare facility with income potential in Mayo, Florida.

    • Established and income‑producing childcare facility.
    • Turnkey operation, fully set up for childcare.
    • Multiple classrooms and child‑friendly spaces.
    • Outdoor play areas designed for safety and engagement.
    • Convenient location amongst schools.
    Updated: Mar 19
    View details
    Commercial Property in Growing Region
    $860,000
    1.46 Acres

    Commercial Property in Growing Region

    130 NE Clyde Avenue, Mayo, FL 32066

    1.46-acre property suitable for various commercial ventures in Mayo, FL.

    • Strategic location halfway between Gainesville and Tallahassee in Mayo, the county seat of Lafayette County.
    • Large 1.46‑acre lot with a 2,623 square foot building suitable for various commercial ventures.
    • Located in the 'Gateway to Growth' region of North Central Florida with a supportive environment for economic development.
    • Built in 2019, featuring brick construction, central heating and air, and a blacktop driveway.
    • Zoning and location suitable for a wide range of service‑oriented businesses, including retail, office, catering, or skilled trades.
    Updated: Sep 8, 2025
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    Lafayette County Land For Sale
    $154,000
    18.10 Acres

    Lafayette County Land For Sale

    18 acres of wooded land near Lafayette Blue Springs State Park.

    000 SW GRACELAND RD., Mayo, FL 32066
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    Nearly 44-Acre Parcel in Mayo
    $300,000
    43.44 Acres

    Nearly 44-Acre Parcel in Mayo

    Large tract of land with endless potential in Mayo, Florida.

    464 Morning Glory Rd., Mayo, FL 32066
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    Sprawling Acreage in Day, Florida
    $299,000
    38.50 Acres

    Sprawling Acreage in Day, Florida

    38.5 acres of lush pastures near Mayo, Florida.

    County Road 53, Mayo, FL 32066
    View details
    211.62 Acres of Farmland
    $634,860
    211.00 Acres

    211.62 Acres of Farmland

    211.62 acres of diverse farmland with recreational opportunities.

    003 Brushy Hammock Road, Mayo, FL 32066
    View details
    45.66 Acres of Farmland
    $228,300
    45.00 Acres

    45.66 Acres of Farmland

    Escape to your natural paradise with this diverse acreage.

    004 Brushy Hammock Road, Mayo, FL 32066
    View details
    40-Acre Rural Escape Land
    $200,100
    40.01 Acres

    40-Acre Rural Escape Land

    40-acre land with diverse mixture of pine and hardwoods.

    002 Brushy Hammock Road, Mayo, FL 32066
    View details
    Downtown Mayo Automotive Business For Sale
    $400,000

    Downtown Mayo Automotive Business For Sale

    Profitable auto shop with inventory and customer database included.

    305 W Main Street, Mayo, FL 32066
    View details
    Based on your search, we've compiled 168 Potential Opportunities for your consideration. Besides 9 Active listings in Mayo, FL, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 155 Off-Market properties to explore as potential leads

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    4.1 Acres Zoned Recreational Activity
    $545,628
    4.10 Acres

    4.1 Acres Zoned Recreational Activity

    4.1 acres in O'Brien, Florida, zoned Recreational Activity Center.

    O Brien, FL 32071
    View details
    Versatile Farm Property For Sale
    $789,000

    Versatile Farm Property For Sale

    79-acre farm with home, fencing, wells, and outbuildings.

    20752 144th St, Live Oak, FL 32060
    View details
    Land Available in Live Oak
    $594,000

    Land Available in Live Oak

    Land for sale in Live Oak, Florida.

    20752 144TH ST (BEHIND), Live Oak, FL 32060
    View details
    Airpark Access Homestead Opportunity
    $85,000

    Airpark Access Homestead Opportunity

    3.6 acre homestead with direct Airpark access.

    O Brien, FL 32071
    View details

    Explore Off-Market Properties in Mayo, FL

    Consider similar Off-Market properties in Mayo, FL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    305 Main St

    305 Main St

    VEHICLE SALES, RENTALS • 2,471 SF
    Value Estimation by Request
    305 Main St, Mayo, FL 32066-4036
    View details
    172 Main St

    172 Main St

    RETAIL STORES (PERSONAL SERVICES) • 8,028 SF
    Value Estimation by Request
    172 Main St, Mayo, FL 32066-4095
    View details
    530 Fletcher Ave

    530 Fletcher Ave

    RESTAURANT • 3,344 SF
    Value Estimation by Request
    530 Fletcher Ave, Mayo, FL 32066-4907
    View details
    294 Main St

    294 Main St

    GROCERY, SUPERMARKET • 12,351 SF
    Value Estimation by Request
    294 Main St, Mayo, FL 32066
    View details
    224 Clyde Ave

    224 Clyde Ave

    NURSERY, GREENHOUSE, FLORIST • 1,975 SF
    Value Estimation by Request
    224 Clyde Ave, Mayo, FL 32066
    View details
    Main St

    Main St

    VACANT COMMERCIAL LAND • 0.00 Acres
    Value Estimation by Request
    Main St, Mayo, FL 32066
    View details
    8540 Main St

    8540 Main St

    WHOLESALE OUTLET, DISCOUNT STORE • 16,400 SF
    Value Estimation
    $575,000
    8540 Main St, Mayo, FL 32066
    View details
    325 Main St

    325 Main St

    STORE/OFFICE (MIXED USE) • 3,024 SF
    Value Estimation by Request
    325 Main St, Mayo, FL 32066
    View details
    757 State Rd 51

    757 State Rd 51

    OFFICE BUILDING • 646 SF
    Value Estimation
    $2,200,000
    757 State Rd 51, Mayo, FL 32066-6609
    View details
    116 Clark Ave

    116 Clark Ave

    STORE/OFFICE (MIXED USE) • 1,535 SF
    Value Estimation by Request
    116 Clark Ave, Mayo, FL 32066
    View details
    253 Bloxham St

    253 Bloxham St

    MANUFACTURING (LIGHT) • 3,072 SF
    Value Estimation by Request
    253 Bloxham St, Mayo, FL 32066
    View details
    968 State Rd 51

    968 State Rd 51

    VEHICLE SALES, RENTALS • 5,298 SF
    Value Estimation by Request
    968 State Rd 51, Mayo, FL 32066-6611
    View details
    536 Nwnw Cir

    536 Nwnw Cir

    VACANT COMMERCIAL LAND • 5.00 Acres
    Value Estimation by Request
    536 Nwnw Cir, Mayo, FL 32066
    View details
    4485 County Rd 53

    4485 County Rd 53

    OFFICE BUILDING • 4,296 SF
    Value Estimation by Request
    4485 County Rd 53, Mayo, FL 32066-2834
    View details
    152 Main St

    152 Main St

    STORE/OFFICE (MIXED USE) • 8,400 SF
    Value Estimation by Request
    152 Main St, Mayo, FL 32066
    View details

    Mayo, FL Commercial Real Estate Investment Opportunities Market Analysis

    Explore 164 commercial real estate for sale in Mayo, FL, showcased through 9 active listings on our real estate platform. These investment opportunities span a total of 3,044 square feet of properties for sale, with an estimated market value of $385,000.

    Sale prices for business properties in Mayo, FL start at $385,000, averaging $385,000, and reaching up to $385,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Most Searched ZIP Codes in Mayo, FL

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