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    Big Pine Key, FL Commercial Real Estate for Sale

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    High-Visibility Commercial Property For Sale
    $3,100,000

    High-Visibility Commercial Property For Sale

    30330 Overseas Hwy, Big Pine Key, FL 33043

    Prime commercial property with high-visibility frontage on Overseas Highway.

    • Prime commercial property with 215 feet of high‑visibility frontage on Overseas Highway (U.S. 1) in Big Pine Key.
    • High‑traffic location near the island's only traffic light, across from CVS, Walgreens, and Ace Hardware.
    • Features 5,250 sq. ft. of retail space occupied by 9 tenants, including long‑term tenants (15+ years).
    • Solid concrete construction with robust roofing system for durability and fire resistance.
    • Includes a 200' radio tower with potential for added revenue.
    Updated: Jan 12
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    Big Pine Key Office Space
    Contact for pricing

    Big Pine Key Office Space

    29872 Overseas Hwy, Big Pine Key, FL 33043

    Professional office space on Overseas Highway in Big Pine Key.

    • High‑visibility location directly on US‑HWY 1, Overseas Hwy in Big Pine Key.
    • Newly renovated office space, ready for immediate occupancy.
    • Features four private offices, ideal for professional use.
    • Elevated building.
    • Two restrooms.
    Updated: Dec 29, 2025
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    99 Don Quixote Ky Big Pne Ky
    $11,000,000

    99 Don Quixote Ky Big Pne Ky

    Specialty properties

    99 Don Quixote Ky Big Pne Ky, Big Pine Key, FL 33043
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    Big Pine Key Retail Investment
    $1,150,000
    3,200 SF

    Big Pine Key Retail Investment

    High-return retail center, 100% occupied.

    30200 Overseas Hwy, Big Pine Key, FL 33043
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    Waterfront Estate Bed and Breakfast
    $4,449,000

    Waterfront Estate Bed and Breakfast

    Historic Florida Keys waterfront estate with income potential.

    1557 Long Beach Dr, Big Pine Key, FL 33043
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    Based on your search, we've compiled 145 Potential Opportunities for your consideration. Besides 5 Active listings in Big Pine Key, FL, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 134 Off-Market properties to explore as potential leads, plus 2 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Vacant Canal-Front Land Available
    $745,000

    Vacant Canal-Front Land Available

    Canal-front vacant land with permit for a four-bedroom house.

    28587 Peg Leg Rd Little Torch Aly, Little Torch Key, FL 33042
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    Little Torch Key Land Assemblage
    $300,000

    Little Torch Key Land Assemblage

    13.67 acres in Little Torch Key, Florida.

    Candice Ave, Little Torch Key, FL 33042
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    Ramrod Key Vacant Land
    $300,000

    Ramrod Key Vacant Land

    6,000 SF vacant lot near Looe Key Reef.

    27426 Martinique Ln, Ramrod Key, FL 33042
    View details
    Florida Keys Income-Producing Assets
    $12,250,000

    Florida Keys Income-Producing Assets

    Rare opportunity: hotel, restaurant, licenses, dive shop, vessel.

    27340 Overseas Hwy, Ramrod Key, FL 33042
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Vacant Land in Big Pine
    $120,000

    Vacant Land in Big Pine

    Vacant land parcel off US-1 with commercial potential.

    6 Vacant Land, Big Pine Key, FL 33043
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    Commercial Land For Sale
    $1,125,000

    Commercial Land For Sale

    Commercial zoned land available with seller financing.

    1 Us Hwy, Big Pine Key, FL 33043
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    Explore Off-Market Properties in Big Pine Key, FL

    Consider similar Off-Market properties in Big Pine Key, FL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    99 Don Quixote Ky Big Pne Ky

    99 Don Quixote Ky Big Pne Ky

    Specialty properties
    Value Estimation by Request
    99 Don Quixote Ky Big Pne Ky, Big Pine Key, FL 33043
    View details
    31251 Avenue A

    31251 Avenue A

    Hospitality properties • 2,450 SF
    Value Estimation by Request
    31251 Avenue A, Big Pine Key, FL 33043
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    Industrial Rd

    Industrial Rd

    LUMBERYARD, BUILDING MATERIALS • 1.13 Acres
    Value Estimation by Request
    Industrial Rd, Big Pine Key, FL 33043
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    Industrial Rd

    Industrial Rd

    STORAGE YARD, OPEN STORAGE • 0.70 Acres
    Value Estimation by Request
    Industrial Rd, Big Pine Key, FL 33043
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    3rd Ave, Unit 1

    3rd Ave, Unit 1

    STORAGE YARD, OPEN STORAGE • 0.92 Acres
    Value Estimation by Request
    3rd Ave, Big Pine Key, FL 33043
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    Watson Blvd

    Watson Blvd

    DISTRIBUTION WAREHOUSE • 2,708 SF
    Value Estimation by Request
    Watson Blvd, Big Pine Key, FL 33043
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    Central Ave

    Central Ave

    STORAGE YARD, OPEN STORAGE • 0.87 Acres
    Value Estimation by Request
    Central Ave, Big Pine Key, FL 33043
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    75 Industrial Rd

    75 Industrial Rd

    STORAGE YARD, OPEN STORAGE • 2.03 Acres
    Value Estimation by Request
    75 Industrial Rd, Big Pine Key, FL 33043-3409
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    75 Industrial Rd

    75 Industrial Rd

    STORAGE YARD, OPEN STORAGE • 1.39 Acres
    Value Estimation by Request
    75 Industrial Rd, Big Pine Key, FL 33043-3409
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    201 Industrial Rd, Unit D

    201 Industrial Rd, Unit D

    DISTRIBUTION WAREHOUSE • 11,820 SF
    Value Estimation
    $1,460,000
    201 Industrial Rd, Big Pine Key, FL 33043-3407
    View details
    30251 Overseas Hwy

    30251 Overseas Hwy

    LUMBERYARD, BUILDING MATERIALS • 5,440 SF
    Value Estimation by Request
    30251 Overseas Hwy, Big Pine Key, FL 33043-3377
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    187 Industrial Rd

    187 Industrial Rd

    LIGHT INDUSTRIAL • 440 SF
    Value Estimation by Request
    187 Industrial Rd, Big Pine Key, FL 33043-3408
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    30801 Ave A A

    30801 Ave A A

    DISTRIBUTION WAREHOUSE • 10,000 SF
    Value Estimation
    $1,445,000
    30801 Ave A A, Big Pine Key, FL 33043-4824
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    50 Chambers St

    50 Chambers St

    DISTRIBUTION WAREHOUSE • 4,800 SF
    Value Estimation
    $635,000
    50 Chambers St, Big Pine Key, FL 33043-3403
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    177 Industrial Rd

    177 Industrial Rd

    LUMBERYARD, BUILDING MATERIALS • 9,000 SF
    Value Estimation by Request
    177 Industrial Rd, Big Pine Key, FL 33043-3408
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    30300 Overseas Hwy

    30300 Overseas Hwy

    DISTRIBUTION WAREHOUSE • 6,240 SF
    Value Estimation
    $900,000
    30300 Overseas Hwy, Big Pine Key, FL 33043-3347
    View details
    100 Industrial Rd

    100 Industrial Rd

    DISTRIBUTION WAREHOUSE • 6,250 SF
    Value Estimation
    $1,300,000
    100 Industrial Rd, Big Pine Key, FL 33043-3405
    View details
    77 Industrial Rd

    77 Industrial Rd

    DISTRIBUTION WAREHOUSE • 6,483 SF
    Value Estimation
    $825,000
    77 Industrial Rd, Big Pine Key, FL 33043-3409
    View details
    31159 Ave B B

    31159 Ave B B

    DISTRIBUTION WAREHOUSE • 2,492 SF
    Value Estimation by Request
    31159 Ave B B, Big Pine Key, FL 33043
    View details

    Big Pine Key, FL Commercial Real Estate Investment Opportunities Market Analysis

    Explore 127 commercial real estate investment opportunities in Big Pine Key, FL on our commercial real estate marketplace. The current inventory includes 3,390,739 square feet of properties with an estimated value of $70,673,000.

    Estimated prices for commercial real estate in Big Pine Key, FL begin at $85,000, with an average of $692,872 and extend to $9,435,000.

    In Big Pine Key, FL, current investment values show:

    • Industrial properties positioned at $449,878
    • Retail properties measuring $802,121
    • Individual retail properties assessed at $734,705
    • Other industrial properties calculated at $565,294
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    Most Searched ZIP Codes in Big Pine Key, FL

    • 33043

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