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    Wise County, VA Commercial Real Estate for Lease

    13 results
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    Commercial Property in Big Stone Gap
    $350,000
    1,400 SF

    Commercial Property in Big Stone Gap

    1809 E 2Nd Ave, Big Stone Gap, VA 24219

    Prominent corner lot suitable for retail or light industrial use.

    • Prominent corner location visible to traffic entering town from US 19.
    • Nearly an acre of fenced land suitable for various uses.
    • Potential for re‑use as convenience retail or light industrial.
    • Existing buildings have utility for service and repair businesses.
    • Office building can be renovated for retail display.
    Updated: Dec 29, 2025
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    Restaurant Opportunity in Big Stone Gap
    $400,000
    2,359 SF

    Restaurant Opportunity in Big Stone Gap

    516 E 5Th St N, Big Stone Gap, VA 24219

    Former Dairy Queen location with drive-thru in downtown Big Stone Gap.

    • Ideal location for a restaurant, formerly a Dairy Queen.
    • High‑visibility downtown location with road frontage.
    • Ready‑to‑go building suitable for immediate occupancy.
    • Ample parking on both sides of the building.
    • Includes a designated drive‑thru area.
    Updated: Dec 17, 2025
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    Commercial Space in Big Stone Gap
    $259,900
    1,400 SF

    Commercial Space in Big Stone Gap

    Versatile commercial space suitable for various businesses in Big Stone Gap.

    11 N 5Th St, Big Stone Gap, VA 24219
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    Commercial Space in Coeburn, VA
    $3,500 / Mo
    8,297 SF

    Commercial Space in Coeburn, VA

    Large commercial space with warehouse storage in Coeburn, Virginia.

    213 E Front St, Coeburn, VA 24230
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    Historic Retail Space in Coeburn
    $3,500 / Mo
    200 SF

    Historic Retail Space in Coeburn

    Unique retail space with historical significance in Coeburn, Virginia.

    417 E Front St, Coeburn, VA 24230
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    Retail Space in Ridgeview Centre
    Contact for pricing
    11,608 SF

    Retail Space in Ridgeview Centre

    Retail space available in a busy Wise, Virginia shopping center.

    129 Rdg Cir, Wise, VA 24293
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    Retail Space in Stonewall Square
    Contact for pricing
    32,236 SF

    Retail Space in Stonewall Square

    Retail space available in Lexington, Virginia's Stonewall Square shopping mall.

    121-181 Plaza Rd SW, Wise, VA 24293
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    Norton, VA Office Suites Available
    $13 SF/Yr
    7,019 SF

    Norton, VA Office Suites Available

    Modern Office Space, Multiple Sizes

    280 Virginia Ave, Norton, VA 24273
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    Ridge View Shopping Center Investment
    Contact for pricing
    156,873 SF

    Ridge View Shopping Center Investment

    Prime Wise, VA retail/office space. Multiple units available.

    181 Plaza Rd, Wise, VA 24293
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    Norton, VA Retail Space Available
    Contact for pricing
    23,145 SF

    Norton, VA Retail Space Available

    High-traffic Co-Tenancy near Rural King

    608 Trent St, Norton, VA 24273
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    Big Stone Gap Retail Center
    Contact for pricing
    18,764 SF

    Big Stone Gap Retail Center

    Retail and office spaces available in Big Stone Gap, Virginia.

    1937-1957 Neeley Rd, Big Stone Gap, VA 24219
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    Powell Valley Shopping Center - Big Stone Gap
    Contact for pricing
    88,637 SF

    Powell Valley Shopping Center - Big Stone Gap

    Prime Retail & Office Space in Southwest Virginia

    1941 Neeley Rd, Big Stone Gap, VA 24219
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    Retail Spaces Available on Main
    Contact for pricing
    4,400 SF

    Retail Spaces Available on Main

    Two retail spaces available for lease on Main Street.

    730 W Main St, Appalachia, VA 24216
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    Based on your search, we've compiled 40 Potential Opportunities for your consideration. Besides 13 Active listings in Wise County, VA, we suggest exploring alternatives. Similar 27 Properties for Sales.

    Explore Similar Spaces for Sale in Wise County, VA

    Consider Similar Space for Sale. We found 27 Spaces in Nearby Locations matching your search parameters.

    Mixed-Use Property in Wise, Virginia
    $350,000
    4,482 SF

    Mixed-Use Property in Wise, Virginia

    Retail space with apartments in the heart of Wise.

    528 W Main St, Wise, VA 24293
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    Car Wash Investment Opportunity
    $795,000
    3,822 SF

    Car Wash Investment Opportunity

    Car wash with income potential in Wise, Virginia.

    123 Woodland Dr, Wise, VA 24293
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    Turnkey Commercial Space in Coeburn
    $275,000
    3,600 SF

    Turnkey Commercial Space in Coeburn

    Versatile 3,600 sqft commercial space suitable for various businesses.

    118 NE Grand Ave, Coeburn, VA 24230
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    Coeburn Multifamily Investment Opportunity
    $1,000,000
    10,000 SF

    Coeburn Multifamily Investment Opportunity

    Four properties with immediate income and significant upside potential.

    207 NE Diagonal Ave, Coeburn, VA 24230
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    Refreshed Commercial Building in St. Paul
    $59,900
    1,000 SF

    Refreshed Commercial Building in St. Paul

    Newly refreshed commercial building in the heart of St. Paul.

    16557 Broad St, Saint Paul, VA 24283
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    Award-Winning Restaurant with Rental Income
    $229,000
    4,000 SF

    Award-Winning Restaurant with Rental Income

    Turn-key restaurant with rental income in historic Appalachia, Virginia.

    516 W Main St, Appalachia, VA 24216
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    Mixed-Use Property in Wise, Virginia
    $350,000
    2,462 SF

    Mixed-Use Property in Wise, Virginia

    Commercial space with apartments in the heart of Wise.

    528 W Main St, Wise, VA 24293
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    Versatile Commercial Building, Big Stone Gap
    $269,900
    6,768 SF

    Versatile Commercial Building, Big Stone Gap

    Spacious commercial building in Big Stone Gap with endless potential.

    510 E Woods Ave, Big Stone Gap, VA 24219
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    Coeburn Commercial Unit For Sale
    $40,500
    675 SF

    Coeburn Commercial Unit For Sale

    Commercial unit featuring four rooms, half bath, and parking.

    340 E Front St, Coeburn, VA 24230
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    Coeburn Historic Mixed-Use Gem
    $485,000

    Coeburn Historic Mixed-Use Gem

    Three-story building with commercial and residential spaces in historic downtown.

    501 Front St, Coeburn, VA 24230
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    Appalachia, VA Commercial Property
    $90,000
    2,874 SF

    Appalachia, VA Commercial Property

    One-story country church with potential for residential or commercial use.

    817 Oakdale St, Appalachia, VA 24216
    View details

    Wise County, VA Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Wise County, VA with 40 listings featured on our commercial real estate exchange. The current inventory includes 675,876,960 square feet of properties with an estimated lease value of $228 SF/Yr.

    Estimated lease rates for Commercial real estate in Wise County, VA begin at $5 SF/Yr, with an average of $76 SF/Yr and extend to $210 SF/Yr.
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    Commercial real estate by market

    Browse Commercial real estate for Lease Near Wise, VA

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