Rio Grande City, TX Commercial real estate for Rent & Lease

Updated: Jun 22

Multi-Suite Retail Space

511 2nd Street, Rio Grande City, TX 78582

$1,000/Mo

3,888 sqft 0.22 AC lot

3,888 square feet of retail property
0.2218‑acre parcel
Multiple commercial suites
Located at 511 2nd Street in Rio Grande City
Just off Expressway 83

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Updated: Apr 15

Highway-Frontage Commercial Land

FM 3167, Rio Grande City, TX 78582

$1,500/Mo

34.00 AC lot

34 acres of commercial land
Approximately 2,960 feet of frontage on FM 3167
Root‑plowed site with perimeter road and fencing
Water meter in place with water extending to the center of the property
Electricity available at the road

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Medical Office Suite

5322 E Us Highway 83 #C-4, Rio Grande City, TX 78582

$3,039/Mo

3,039 sqft Built 2004

Highway access

A room-diverse space in an established medical plaza includes dedicated diagnostic, treatment, and administrative areas.

160 parking spaces

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Medical Office Suite

5322 E Us Highway 83 #C-5, Rio Grande City, TX 78582

$3,003/Mo

3,003 sqft Built 2004

Highway access

A multi-room layout includes a reception area, office, breakroom, and separate restroom facilities.

160 parking spaces

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Medical Office Suite

5322 E Us Highway 83 #C-2, Rio Grande City, TX 78582

$2,925/Mo

2,925 sqft Built 2004

Highway access

Available for lease, the multi-room space includes reception, private offices, workstations, storage, and two restrooms.

160 parking spaces

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Medical Office Suite

C-5-5322 E Us Highway 83, Rio Grande City, TX 78582

$3,003/Mo

3,003 sqft

Highway access Road access

A multi-room commercial suite includes reception, office, breakroom, and control room areas.

160 parking spaces

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Medical Office Suite

C-2-5322 E Us Highway 83, Rio Grande City, TX 78582

$2,925/Mo

2,925 sqft

Highway access Road access

A multi-room configuration includes private offices, five workstations, and two restrooms.

160 parking spaces

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Retail Suite with Drive-Through

5322 E Us Highway 83 #C-1, Rio Grande City, TX 78582

$3,816/Mo

3,816 sqft Built 2004

Highway access

A former pharmacy occupies a suite in a medical plaza on US Highway 83.

160 parking spaces Drive-thru Flexible layout Excellent visibility

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Medical Office Suite

C-4-5322 E Us Highway 83, Rio Grande City, TX 78582

$3,039/Mo

3,039 sqft

Highway access Road access

A multi-room clinical layout includes a reception lobby, radiology and lab rooms, exam areas, and dedicated support spaces.

160 parking spaces

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Medical Office Suite

5326 E Us Highway 83 #A-1, Rio Grande City, TX 78582

$4,032/Mo

3,150 sqft Built 2007

Positioned within a medical plaza, the space offers a healthcare-focused setting in Rio Grande City.

135 parking spaces

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Downtown Retail Space

300 E Main Street E, Rio Grande City, TX 78582

$9,600/Mo

10,829 sqft Built 1950

The property is in downtown Rio Grande City and carries C zoning.

30 parking spaces

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Retail Suite

302 E 2nd Street #B, Rio Grande City, TX 78582

$2,900/Mo

2,900 sqft Built 1985

The commercial space is near City Hall, banks, and restaurants.

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Retail Suite in Planned Center

4791 Us Highway 83 #102, Rio Grande City, TX 78582

$5,880/Mo

1,680 sqft 3,850 GLA Built 2026

Highway access

A future retail development on US Highway 83 will sit beside Dutch Bros and near national retailers.

25 parking spaces

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Office Suites for Lease

511 2nd Street, Rio Grande City, TX 78582

$1,000/Mo

15–25 people 3,888 sqft

Highway access

Office suites for lease near Expressway 83, with flexible space for office, medical, and wellness uses.

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Planned Strip Center Retail Space

4791 Us Highway 83 #101, Rio Grande City, TX 78582

$7,595/Mo

2,170 sqft Built 2026

Highway access

Suite 101 is part of a proposed retail development near Dutch Bros and national retailers along US Highway 83.

25 parking spaces

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Premier Plaza Retail Unit

2-216 N Fm 3167, Rio Grande City, TX 78582

$1,650/Mo

12,100 sqft

Commercial space suited to retail, professional office, or service-oriented business uses.

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Versatile Retail Space

B-302 E 2nd St, Rio Grande City, TX 78582

$2,900/Mo

2,900 sqft

Commercial suite near City Hall, banks, restaurants, and other everyday amenities.

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New Construction Strip Center

4791 E US Highway 83, Rio Grande City, TX 78582

$39 SF/Yr

Highway access

Retail space fronts US Highway 83 beside Dutch Bros in Rio Grande City, with access to the area’s primary east-west route.

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High-Traffic Retail Space

2500 East US Highway 83, Rio Grande City, TX 78582

Contact for pricing

15,518 sqft Built 1992

Highway access

Retail space for lease on a high-traffic US Highway 83 corridor adjacent to Lacks Furniture.

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Flex Space with Warehouse

1999 Embassy Street, Rio Grande City, TX 78582

$5,500/Mo

1,000 sqft 1,300 sqft office 17,000 sqft warehouse

A mixed office and warehouse layout includes enclosed and open areas, plus covered concrete space.

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Commercial Land at Grocery-Anchored Center

4023 US-83, Rio Grande City, TX 78582

Contact for pricing

Highway access Road access

Commercial land within Starr Plaza, anchored by HEB and Marshalls and located on US 83 near the Mexico bridge.

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Highway Frontage Retail Pad Site

4043 E. Hwy 83, Rio Grande City, TX 78582

Contact for pricing

8,168 sqft

1.18 acre pad site with highway frontage and great visibility.

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Medical Office Space in Plaza

A-1-5326 E Us Highway 83, Rio Grande City, TX 78582

$4,032/Mo

3,150 sqft

The suite is situated in Rio Grande City near municipal offices and several retail businesses.

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Freestanding Medical Office Space

Rio Grande City, TX 78582

Contact for pricing

Built 2000

Move-in-ready facility features reception, private offices, exam rooms, and covered parking.

Covered parking Breakroom/lockers

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