Winnsboro, SC Commercial real estate for Rent & Lease

Updated: Sep 7

Grocery-Anchored Shopping Center

25-123 US Highway 321 Bypass, Winnsboro, SC 29180

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Grocery‑store‑anchored shopping center
Frontage along US 321 Bypass and Moultrie Street
Located at 25‑123 US Highway 321 Bypass, Winnsboro, SC 29180
Retail space available for lease

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Updated: Nov 21, 2025

Former Restaurant on Highway 321

195 U.S. 321 Bypass, Winnsboro, SC 29180

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2,393 sqft

Free‑standing QSR building, formerly a Burger King.
Outparcel to KJ's grocery store.
Located on Hwy 321 in Winnsboro, SC.
Available for sale or lease.
Near national retailers including KFC, Pizza Hut, and McDonald's.

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Based on your search, we've compiled 17 Potential Opportunities for your consideration. Besides 2 Active listings in Winnsboro, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 11 Properties for Sales.

Commercial real estate for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Executive Office Suite with Conference Rooms

1131 Northpoint Blvd, Blythewood, SC 29016

$19 SF/Yr

Executive office suites with private exterior offices, reception space, and conference rooms for flexible teams.

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Retail Space for Lease

420 McNulty Street, Blythewood, SC 29016

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Retail space is available for lease, positioned off I-77 at the same exit as a nearby manufacturing facility.

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Irmo Commercial Land For Rent

Irmo, SC 29063

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Commercial land available for rent in Irmo, South Carolina.

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Retail Space in Kroger-Anchored Center

7467 St Andrews Rd., Irmo, SC 29063

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99,384 sqft

Retail spaces available in a Kroger-anchored shopping center.

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Similar Spaces for Sale in Winnsboro, SC

Consider Similar Space for Sale. We found 11 Spaces matching your search parameters.

Spa & Wellness Property with Tanning Beds

218 Congress Street, Winnsboro, SC 29180

$150,000

1,456 sqft 0.27 AC lot

Existing salon improvements include treatment stations, tanning equipment, customer amenities, and a dedicated laundry area.

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Interstate-Adjacent Commercial Land

2440 Camp Welfare Road, Winnsboro, SC 29180

$3,393,000

33 sqft

B-2-zoned commercial land with access from Camp Welfare Road and Parallel Drive at an interstate interchange.

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Manufacturing Facility with Dock

1214 State Highway 34 E, Winnsboro, SC 29180

$2,600,000

76,000 sqft

I-1-zoned industrial facility with substantial production, office, and workforce-support areas plus highway and interstate connectivity.

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Spa & Wellness Property

218 Congress Street, Winnsboro, SC 29180

$150,000

1,456 sqft

Operating hair salon with dedicated service areas, tanning equipment, laundry facilities, and paved parking.

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I-1 Industrial Land

1008 State Hwy 34 East, Winnsboro, SC 29180

$1,122,500

44 sqft

Rolling acreage with water, sewer, gas, electric, and telecom availability along SC Hwy 34.

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Industrial Land with Highway Access

1678 State Hwy 34 East, Winnsboro, SC 29180

$3,250,000

130 sqft

I-1-zoned acreage offers available water, sewer, natural gas, electrical service, and telecommunications for industrial development.

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Automotive Repair Shop

151 Columbia Road, Winnsboro, SC 29180

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1,680 sqft 1.00 AC lot

Leased automotive repair facility with a metal building, secured yard, office entry, and multiple commercial access routes.

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Partially Occupied Retail Building

314 S Congress Street, Winnsboro, SC 29150

$85,000

1,980 sqft 0.22 AC lot

C1-zoned property on S Congress Street includes central air and space for additional occupancy.

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Winnsboro Commercial Property For Sale

1132 Kincaid Brg Rd, Winnsboro, SC

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30,108 sqft 3.41 AC lot

Commercial property featuring office, warehouse, and storefront spaces for sale.

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Agricultural Land with Creek

1400 Little River Road, Winnsboro, SC 29180

$349,900

36.80 AC lot

Wooded and partially cleared acreage with internal trails, a well, electrical service, and a creek crossing the property.

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Downtown Winnsboro Retail/Office Building

401 N Congress St, Winnsboro, SC 29180

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2,265 sqft

Retail/office building for sale in downtown Winnsboro.

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