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    Saco, ME Commercial Real Estate for Lease

    16 results
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    Saco Medical Office Suite
    $13 SF/Yr
    10,000 SF

    Saco Medical Office Suite

    655 Main St, Saco, ME

    10,000± SF medical office suite for rent.

    • 10,000± SF medical office suite
    • Located just off I‑195 and Route One
    • Convenient to downtown Saco
    • Highly visible location
    • Second floor suite
    Updated: Oct 6, 2025
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    Saco Riverfront Office/Warehouse Building
    Contact for pricing
    6,000 SF

    Saco Riverfront Office/Warehouse Building

    44 Lincoln St, Saco, ME

    Turn-key office/warehouse near Maine Turnpike and walkable to downtowns.

    • Turn‑key, modern office/warehouse building.
    • Located on the Saco River.
    • Easily accessible between Exits 32 and 36 on the Maine Turnpike (I‑95).
    • Includes large paved area for parking/storage on 0.88± acre parcel.
    • 60% recently renovated office and 40% warehouse with 10x12' OH door.
    Updated: Nov 24, 2025
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    High Bay Warehouse Space Available
    $10 SF/Yr
    30,195 SF

    High Bay Warehouse Space Available

    30,195± SF high bay warehouse space for sublease.

    14 Phillips Spring Road, Saco, ME
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    New Build-to-Suit Saco Warehouse
    Contact for pricing
    18,200 SF

    New Build-to-Suit Saco Warehouse

    Customizable warehouse space in Saco's prime industrial zone.

    4 Lehner Rd, Saco, ME
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    Downtown Saco Office Space Available
    $18 SF/Yr
    1,772 SF

    Downtown Saco Office Space Available

    Office/studio space for rent in downtown Saco.

    209 Main Street, Saco, ME
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    Retail/Athletic Space in Saco
    $25 SF/Yr
    1,508 SF

    Retail/Athletic Space in Saco

    1,508± SF retail/athletic space in a sports medicine complex.

    15 Lund Rd, Saco, ME
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    Industrial Build-to-Suit Opportunity, Saco
    Contact for pricing
    63,000 SF

    Industrial Build-to-Suit Opportunity, Saco

    63,000± SF build-to-suit industrial building on US Route 1.

    1016 Portland Rd, Saco, ME
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    Industrial Build-to-Suit Opportunity
    Contact for pricing
    75,000 SF

    Industrial Build-to-Suit Opportunity

    Industrial build-to-suit opportunity in Saco, less than 5 miles from I-95.

    955 Portland Rd, Saco, ME 4072
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    8 Acres Build-to-Suit Land
    Contact for pricing

    8 Acres Build-to-Suit Land

    8+/- acre land parcel available for lease or build-to-suit.

    991 Portland Rd, Saco, ME
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    Industrial Build-to-Suit Opportunity
    Contact for pricing
    75,000 SF

    Industrial Build-to-Suit Opportunity

    Industrial build-to-suit opportunity in Saco, Maine, near I-95.

    955 Portland Rd, Saco, ME 4072
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    Saco Gas/Convenient Store Site
    Contact for pricing

    Saco Gas/Convenient Store Site

    Prime development site on Main Street in Saco, Maine.

    650 Main Street, Saco, ME 4072
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    Retail Space on Main Street
    Contact for pricing
    1,400 SF

    Retail Space on Main Street

    Single tenant retail space available for rent.

    507 Main St, Saco, ME 4072
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    Saco Flex Space For Lease
    $13 SF/Yr
    4,590 SF

    Saco Flex Space For Lease

    Flex space suitable for office or medical office use.

    42 Industrial Park Rd, Saco, ME 4072
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    Retail/Athletic Space in Saco
    Contact for pricing

    Retail/Athletic Space in Saco

    Retail/athletic space in OA Sports Center complex, accessible from I-195.

    15 Lund Rd, Saco, ME 4072
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    Prime Retail Building on Corner
    Contact for pricing

    Prime Retail Building on Corner

    Stand-alone retail building for lease in Saco's commercial corridor.

    70 Elm St, Saco, ME 4072
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    Saco Flex Space Available
    Contact for pricing
    4,590 SF

    Saco Flex Space Available

    Flex space suitable for office or medical office use.

    42 Industrial Park Rd, Saco, ME 4072
    View details
    Based on your search, we've compiled 36 Potential Opportunities for your consideration. Besides 16 Active listings in Saco, ME, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 16 Properties for Sales.

    Explore Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Downtown Biddeford Commercial Studio Space
    $1,300 /Mo
    954 SF

    Downtown Biddeford Commercial Studio Space

    Commercial studio space in downtown Biddeford, ideal for manufacturing.

    22 Pearl St, Biddeford, ME
    View details
    Riverfront Retail Space in Biddeford
    $8 SF/Yr
    2,249 SF

    Riverfront Retail Space in Biddeford

    2,249± sf retail space along the Riverfront in Biddeford.

    28 Pearl Street, Biddeford, ME
    View details
    Historic Mill Campus Commercial Space
    $20 SF/Yr
    630 SF

    Historic Mill Campus Commercial Space

    Revitalized mill campus offering flexible commercial suites for lease.

    2 Main St Ste 37-101, Biddeford, ME
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    Prime Retail and Dining Hub
    Contact for pricing

    Prime Retail and Dining Hub

    New construction retail and dining space in downtown Biddeford.

    30 Gooch St, Biddeford, ME 4005
    View details

    Explore Similar Spaces for Sale in Saco, ME

    Consider Similar Space for Sale. We found 16 Spaces matching your search parameters.

    Historic Brick Building in Saco
    $995,000
    8,736 SF

    Historic Brick Building in Saco

    Iconic, fully leased, historic brick building in downtown Saco, Maine.

    190 Main Street, Saco, ME 04072
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    Saco Commercial Building For Sale
    $2,900,000
    10,260 SF

    Saco Commercial Building For Sale

    Commercial building in Saco, Maine, suitable for multiple uses.

    5 Willey Road, Saco, ME 04072
    View details
    Mixed-Use Property in Saco, ME
    $724,900
    4,976 SF

    Mixed-Use Property in Saco, ME

    Mixed-use property with retail and office spaces in Saco.

    239 Main Street, Saco, ME 04072
    View details
    Saco Commercial Opportunity Zone Property
    $2,300,000
    10,550 SF

    Saco Commercial Opportunity Zone Property

    2.28 acres with building and development potential in Saco, Maine.

    644 Main Street, Saco, ME 04072
    View details
    Saco Commercial Property with Development Potential
    $2,300,000
    10,550 SF

    Saco Commercial Property with Development Potential

    2.28-acre property with building, buildable lot, and high traffic.

    644 Main Street, Saco, ME 4072
    View details
    Industrial Condominium in Saco, Maine
    $585,000
    3,150 SF

    Industrial Condominium in Saco, Maine

    3,150 SF industrial condominium suitable for storage or business.

    24 Industrial Park Rd, Saco, ME
    View details
    Saco Land Ideal for Development
    $1,650,000
    16.37 Acres

    Saco Land Ideal for Development

    Large 16.37-acre tract suited for multi-family or hospitality development.

    642 Main Street, Saco, ME 04072
    View details
    Prime Retail Investment Opportunity
    $2,350,000
    1.39 Acres

    Prime Retail Investment Opportunity

    High-visibility retail property with long-term tenants and income potential.

    937 Portland Rd, Saco, ME
    View details

    Saco, ME Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Saco, ME with 16 listings featured on our commercial real estate exchange. The current inventory includes 501,288,480 square feet of properties with an estimated lease value of $38 SF/Yr.

    Estimated lease rates for Commercial real estate in Saco, ME begin at $13 SF/Yr, with an average of $19 SF/Yr and extend to $25 SF/Yr.
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