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    Port Saint Lucie, FL Commercial Real Estate for Lease

    46 results
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    Medical Building in Port St. Lucie
    $25 SF/Yr
    10,032 SF

    Medical Building in Port St. Lucie

    1405 SE Goldtree Dr, Port Saint Lucie, FL 34952

    Turnkey medical building near HCA Florida St. Lucie Hospital.

    • Turnkey & Completely Built‑out Medical Building Ready for Immediate Occupancy
    • Located in Prominent Medical Area Adjacent to HCA Florida St. Lucie Hospital
    • Approximately 10,032 sqft Available with Flexible Configuration (Contiguous or 5 Suites)
    • Approximately 50 Parking Spaces
    • NNN Lease at $25/sqft plus CAM $8.43/sqft with 2% Annual Increases
    Updated: Feb 23
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    Versatile Commercial Property in Port St. Lucie
    $1,500,000
    1,242 SF

    Versatile Commercial Property in Port St. Lucie

    1892 SW Biltmore St, Port Saint Lucie, FL 34984

    Two properties with flexibility for commercial or residential use.

    • High‑visibility location in a rapidly growing commercial corridor of Port St. Lucie.
    • Combined sale of two properties (481 SW Voltaire Ave and 1892 SW Biltmore St) totaling approximately 0.55 acres.
    • Excellent proximity to Florida's Turnpike and I‑95.
    • Oversized parcels with excellent frontage, ample parking, and fully usable fenced outdoor space.
    • Single‑family structures on each site offer flexibility for residential, office, or business use.
    Updated: Mar 5
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    Profitable Office Space with Tenants
    $275,000

    Profitable Office Space with Tenants

    Turnkey office property with long-term tenants and immediate cash flow.

    544 NW University Blvd Blvd, Port Saint Lucie, FL 34986
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    Westport Plaza Retail Space Available
    Contact for pricing
    1,165 SF

    Westport Plaza Retail Space Available

    Retail space in Westport Plaza with high traffic and visibility.

    2854-2872 SW Port St Lucie Blvd, Port Saint Lucie, FL 34953
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    Retail Space in Tradition
    Contact for pricing
    2,800 SF

    Retail Space in Tradition

    Retail space available in a master-planned community shopping center.

    10770 SW Village Pkwy, Port Saint Lucie, FL 34987
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    Industrial Flex Condo For Rent
    $17 SF/Yr
    1,200 SF

    Industrial Flex Condo For Rent

    Versatile 1,200 SF industrial flex condo with offices.

    1547-1561 South Niemeyer Cir, Port Saint Lucie, FL
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    Port St. Lucie Office Space
    $27 SF/Yr
    2,500 SF

    Port St. Lucie Office Space

    2,500 SF office space in a thriving commercial corridor.

    155 SW Port St Lucie Blvd, Port Saint Lucie, FL 34984
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    Industrial Space Available For Lease
    $15 SF/Yr
    2,500 SF

    Industrial Space Available For Lease

    2,500 square feet of industrial space for rent.

    574 NW Mercantile Pl, Port Saint Lucie, FL 34986
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    Port St. Lucie Retail Space
    Contact for pricing
    1,042 SF

    Port St. Lucie Retail Space

    Retail space for lease in Port St. Lucie, Florida.

    7630 S Us Hwy 1, Port Saint Lucie, FL
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    St. Lucie West Flex Space
    Contact for pricing
    1,800 SF

    St. Lucie West Flex Space

    Flexible bays near I-95 and Florida’s Turnpike.

    664 NW Enterprise Dr, Port Saint Lucie, FL 34986
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    St. Lucie West Flex Space
    Contact for pricing
    5,400 SF

    St. Lucie West Flex Space

    Flex space near I-95 and Florida Turnpike.

    660 NW Enterprise Dr, Port Saint Lucie, FL 34986
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    Port St. Lucie Warehouse Space
    $18 SF/Yr
    1,500 SF

    Port St. Lucie Warehouse Space

    1500 SF warehouse space for lease in Port St. Lucie.

    1669 South Niemeyer Cir, Port Saint Lucie, FL
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    Commercial Land for Lease
    Contact for pricing

    Commercial Land for Lease

    Land available for retail, restaurant, hotel, or commercial development.

    SW Cameo Blvd, Port Saint Lucie, FL 34953
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    St Lucie West Professional Offices
    Contact for pricing
    3,076 SF

    St Lucie West Professional Offices

    Medical and professional offices in the heart of St Lucie West.

    525 NW Lake Whitney Pl, Port Saint Lucie, FL 34986
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    Medical Office Space For Rent
    Contact for pricing
    1,288 SF

    Medical Office Space For Rent

    Medical office space in Gatlin Kidney Care medical facility.

    1631 SW Gatlin Blvd, Port Saint Lucie, FL 34953
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    Jetson Plaza Retail Spaces
    $30 SF/Yr
    31,348 SF

    Jetson Plaza Retail Spaces

    Port St. Lucie Medical & Retail Suites

    1908 Gatlin Blvd, Port Saint Lucie, FL 34953
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    Prime Land for Lease
    Contact for pricing

    Prime Land for Lease

    Available land for lease, ideal for retail and more.

    4390 SW Yamada Dr, Port Saint Lucie, FL 34953
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    Port St. Lucie Warehouse Space
    Contact for pricing
    2,000 SF

    Port St. Lucie Warehouse Space

    2,000 SF warehouse with office, roll-up doors, ample parking.

    1593 SE Village Green Dr, Port Saint Lucie, FL 34952
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    Warehouse Units with Easy Access
    Contact for pricing
    1,500 SF

    Warehouse Units with Easy Access

    Warehouse units with tall ceilings, roll-up doors, and ample parking.

    792 SW Grove Ave, Port Saint Lucie, FL 34983
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    Port St. Lucie Land Lease
    Contact for pricing

    Port St. Lucie Land Lease

    Land lease opportunity near Publix and Florida's Turnpike.

    1091 SE Port St Lucie Blvd, Port Saint Lucie, FL 34952
    View details

    Explore Similar Spaces for Sale in Port Saint Lucie, FL

    Consider Similar Space for Sale. We found 67 Spaces in Nearby Locations matching your search parameters.

    Port Saint Lucie Warehouse Condo
    $375,000
    1,500 SF

    Port Saint Lucie Warehouse Condo

    1,750 SF warehouse condo with office space and mezzanine.

    581 NW Mercantile Pl, Port Saint Lucie, FL 34986
    View details
    Prime Commercial Land on US-1
    $999,888
    0.79 Acres

    Prime Commercial Land on US-1

    High-traffic US-1 frontage, general commercial zoning, versatile potential.

    10720 S Us Highway 1 U.S, Port Saint Lucie, FL 34952
    View details
    Turnkey Hair Salon Opportunity
    $49,000
    1,000 SF

    Turnkey Hair Salon Opportunity

    Fully equipped hair salon with strong client base for sale.

    6969 Hancock Dr, Port Saint Lucie, FL 34952
    View details
    Port St. Lucie Commercial Condo
    $235,000
    814 SF

    Port St. Lucie Commercial Condo

    Turnkey showroom/office/warehouse space in established Port St. Lucie district.

    1459 SE Village Green Dr, Port Saint Lucie, FL 34952
    View details

    Port Saint Lucie, FL Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Port Saint Lucie, FL with 113 listings featured on our commercial real estate exchange. The current inventory includes 7,715,434,320 square feet of properties with an estimated lease value of $259 SF/Yr.

    Estimated lease rates for Commercial real estate in Port Saint Lucie, FL begin at $1.47 SF/Yr, with an average of $19 SF/Yr and extend to $32 SF/Yr.
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