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    Port Saint Lucie, FL Commercial Real Estate for Lease

    52 results
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    Mixed-Use Property Near Florida's Turnpike
    $3,300 / Mo
    1,524 SF

    Mixed-Use Property Near Florida's Turnpike

    481 SW Voltair Ter, Port Saint Lucie, FL 34984

    Versatile mixed-use property suitable for business, retail, or residential use.

    • Oversized 13,750 SF lot with business, office, studio, retail, or mixed‑use potential.
    • Ideally located minutes from Florida's Turnpike and I‑95.
    • Suitable for service‑based professionals or outdoor‑oriented businesses.
    • 3‑bedroom, 2‑bath home adaptable for residence, office, storage, or operational space.
    • Recent improvements include a new roof, luxury vinyl flooring, and updated kitchen.
    Updated: Jan 27
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    Mixed-Use Property Near Turnpike
    $3,300 / Mo
    1,524 SF

    Mixed-Use Property Near Turnpike

    1892 SW Biltmore St, Port Saint Lucie, FL 34984

    Flexible mixed-use property with residential and commercial potential.

    • Oversized 10,000 SF lot with outstanding flexibility.
    • Ideally located minutes from Florida's Turnpike and I‑95.
    • Suitable for service‑based professionals or outdoor‑oriented businesses.
    • Includes a 3‑bedroom, 2‑bath home adaptable for residence, office, or storage.
    • Recent improvements include a new roof, modern plank tile flooring, and updated kitchen.
    Updated: Jan 17
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    Profitable Office Space with Tenants
    $275,000

    Profitable Office Space with Tenants

    Turnkey office property with long-term tenants and immediate cash flow.

    544 NW University Blvd Blvd, Port Saint Lucie, FL 34986
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    Port St. Lucie Retail Space
    $24 SF/Yr
    4,050 SF

    Port St. Lucie Retail Space

    Retail space for lease in Port St. Lucie, Florida.

    7630 S Us Hwy, Port Saint Lucie, FL
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    Jetson Plaza Retail Spaces
    $30 SF/Yr
    31,348 SF

    Jetson Plaza Retail Spaces

    Port St. Lucie Medical & Retail Suites

    1908 Gatlin Blvd, Port Saint Lucie, FL 34953
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    Port St. Lucie Flex Building
    $14 SF/Yr
    48,720 SF

    Port St. Lucie Flex Building

    Industrial flex building with air-conditioned office space for lease.

    651 NW Enterprise Dr, Port Saint Lucie, FL 34986
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    St. Lucie West Office Space
    $23 SF/Yr
    45,416 SF

    St. Lucie West Office Space

    Professional and Medical office space in landmark building for lease.

    1660 SW St. Lucie Blvd West, Port Saint Lucie, FL 34986
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    Retail Space in Tradition
    Contact for pricing
    2,800 SF

    Retail Space in Tradition

    Retail space available in a master-planned community shopping center.

    10770 SW Village Pkwy, Port Saint Lucie, FL 34987
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    St. Lucie West Flex Space
    $20 SF/Yr
    3,600 SF

    St. Lucie West Flex Space

    Flexible bays near I-95 and Florida’s Turnpike.

    664 NW Enterprise Dr, Port Saint Lucie, FL 34986
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    Retail and Warehouse Spaces Available
    $20 SF/Yr
    703 SF

    Retail and Warehouse Spaces Available

    Retail and warehouse spaces available in Port St. Lucie, Florida.

    466 SW Port St Lucie Blvd, Port Saint Lucie, FL 34953
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    St Lucie West Professional Offices
    $25 SF/Yr
    3,076 SF

    St Lucie West Professional Offices

    Medical and professional offices in the heart of St Lucie West.

    525 NW Lake Whitney Pl, Port Saint Lucie, FL 34986
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    Shared Medical Office Space
    $3,500 / Mo
    1,604 SF

    Shared Medical Office Space

    Shared medical office space available near hospital and major roadways.

    10377 S Us Hwy, Port Saint Lucie, FL
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    Port Saint Lucie Office Space
    $22 SF/Yr
    8,500 SF

    Port Saint Lucie Office Space

    Office space available for lease in Port Saint Lucie.

    584 NW University Blvd, Port Saint Lucie, FL 34986
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    Port St. Lucie Warehouse Space
    $16 SF/Yr
    1,187 SF

    Port St. Lucie Warehouse Space

    Industrial warehouse space available for lease in Port St. Lucie.

    886 SW Biltmore St, Port Saint Lucie, FL 34983
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    Port Saint Lucie Office Space
    $15 SF/Yr
    13,029 SF

    Port Saint Lucie Office Space

    Office space available for lease in Port Saint Lucie, FL.

    900 E Prima Vista Blvd, Port Saint Lucie, FL 34952
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    Port St. Lucie Flex Unit
    $349,999
    1,600 SF

    Port St. Lucie Flex Unit

    Flex unit in West Park Industrial Center for lease.

    571 NW Mercantile Pl, Port Saint Lucie, FL 34986
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    New Class A Medical Space
    $32 SF/Yr
    2,616 SF

    New Class A Medical Space

    End-cap space in new medical building on Gatlin Blvd.

    1070 SW Gatlin Blvd, Port Saint Lucie, FL 34953
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    Port St. Lucie Office Space
    $18 SF/Yr
    3,753 SF

    Port St. Lucie Office Space

    Versatile office space in a high-traffic Port St. Lucie location.

    7664 S Us Hwy, Port Saint Lucie, FL
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    Medical Office Space For Rent
    $25 SF/Yr
    1,288 SF

    Medical Office Space For Rent

    Medical office space in Gatlin Kidney Care medical facility.

    1631 SW Gatlin Blvd, Port Saint Lucie, FL 34953
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    Port St. Lucie Office Space
    $27 SF/Yr
    2,500 SF

    Port St. Lucie Office Space

    2,500 SF office space in a thriving commercial corridor.

    155 SW Port St Lucie Blvd, Port Saint Lucie, FL 34984
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    Retail Space in Anchored Center
    $12 SF/Yr
    10,260 SF

    Retail Space in Anchored Center

    Retail space available in a high-traffic, anchored shopping center.

    10055-10193 S Us Hwy, Port Saint Lucie, FL
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    Industrial Warehouse Space For Lease
    Contact for pricing
    19,900 SF

    Industrial Warehouse Space For Lease

    Industrial warehouse space with truck court, preleasing for 2026.

    NW Ltc Pkwy, Port Saint Lucie, FL 34986
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    Freestanding Restaurant with Drive-Thru
    $32 SF/Yr
    2,657 SF

    Freestanding Restaurant with Drive-Thru

    Restaurant building with drive-thru on a high-traffic highway.

    10401 S Us Hwy, Port Saint Lucie, FL
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    Port St. Lucie Office Suite
    $3,114 / Mo
    833 SF

    Port St. Lucie Office Suite

    Executive office suite in Port St. Lucie medical corridor.

    2100 SE Hillmoor Dr, Port Saint Lucie, FL 34952
    View details

    Port Saint Lucie, FL Commercial Real Estate Leasing Opportunities Market Analysis

    Explore Commercial Real Estate leasing options in Port Saint Lucie, FL with 78 listings featured on our commercial real estate exchange. The current inventory includes 11,802,364,200 square feet of properties with an estimated lease value of $941 /Mo.

    Estimated lease rates for Commercial Real Estate in Port Saint Lucie, FL begin at $1.47 SF/Yr, with an average of $21 SF/Yr and extend to $44 SF/Yr.

    In Port Saint Lucie, FL, current lease rates show:

    • Office Properties & Spaces positioned at $24
    • Office space measuring $23
    • Industrial properties assessed at $17
    • Other warehouses calculated at $17
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    Browse Commercial real estate for Lease Near Port Saint Lucie, FL

    Popular Searches in Port Saint Lucie, FL

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    Most Searched ZIP Codes in Port Saint Lucie, FL

    • 34986
    • 34953
    • 34952
    • 34987
    • 34984
    • 34983
    • 349532621

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