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    Port Charlotte, FL Commercial Real Estate for Lease

    72 results
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    Professional Space Ideal for Healthcare
    $5,200 / Mo
    3,408 SF

    Professional Space Ideal for Healthcare

    2484 Caring Way, Port Charlotte, FL 33952

    Sub-lease opportunity for healthcare, wellness, or medical practices.

    • Turn‑key professional space ideal for healthcare, wellness, or medical practices.
    • Up to 8 treatment rooms available, 6 equipped with individual sinks.
    • Flexible floor plan - sublease one treatment room, several rooms, or the whole office.
    • 5 total bathrooms, including one private bathroom in a suite.
    • Spacious reception and waiting area.
    Updated: Nov 18, 2025
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    Versatile Retail/Office Condo in Charlotte
    $17 SF/Yr
    1,044 SF

    Versatile Retail/Office Condo in Charlotte

    701 J C Center Ct, Port Charlotte, FL 33954

    Adaptable 1,044 SF condo ideal for retail or office use.

    • Prime location in Port Charlotte's The Vines Commercial Condominiums.
    • Flexible 1,044 sq ft retail/office condominium suitable for various businesses.
    • Open layout design.
    • Includes a private restroom.
    • Ample shared parking available.
    Updated: Oct 12, 2025
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    High-Traffic Plaza with Drive-Thru
    $20 SF/Yr
    4,193 SF

    High-Traffic Plaza with Drive-Thru

    Flexible retail/office space with drive-thru in a high-traffic location.

    2672-2686 Tamiami Trl, Port Charlotte, FL 33952
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    Prime Commercial Space on Highway
    $15 SF/Yr
    5,520 SF

    Prime Commercial Space on Highway

    1058 SF commercial space ideal for professional business.

    2032 El Jobean Rd, Port Charlotte, FL 33948
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    Port Charlotte Commercial Space Available
    $20 SF/Yr
    1,000 SF

    Port Charlotte Commercial Space Available

    Commercial space suitable for medical or general office use.

    3221 Tamiami Trl, Port Charlotte, FL 33952
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    Versatile Commercial Space Available
    $16 SF/Yr
    19,597 SF

    Versatile Commercial Space Available

    Adaptable commercial space with prime visibility and functional layout.

    983 Tamiami Trl, Port Charlotte, FL 33953
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    Port Charlotte Medical Office Space
    $20 SF/Yr
    1,196 SF

    Port Charlotte Medical Office Space

    Medical office space in the Port Charlotte medical district.

    3417 Tamiami Trl, Port Charlotte, FL 33952
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    Medical Office in Parkside District
    $17 SF/Yr
    2,564 SF

    Medical Office in Parkside District

    Medical office space for lease near two hospitals.

    2484 Caring Way, Port Charlotte, FL 33952
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    Medical Office in Parkside District
    $16 SF/Yr
    3,333 SF

    Medical Office in Parkside District

    Medical office space for lease near two hospitals.

    2484 Caring Way, Port Charlotte, FL 33952
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    Punta Gorda Mixed-Use Space
    $13 SF/Yr
    4,904 SF

    Punta Gorda Mixed-Use Space

    Prime mixed-use space in a growing Florida location.

    23180 Harper Ave, Port Charlotte, FL 33980
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    Professional Garden Condo Office Suite
    $15 SF/Yr
    1,706 SF

    Professional Garden Condo Office Suite

    Well-located office suite ideal for medical or professional use.

    3443 Tamiami Trl, Port Charlotte, FL 33952
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    Remodeled Commercial Space Available
    Contact for pricing
    44,867 SF

    Remodeled Commercial Space Available

    Remodeled commercial space in landmark Port Charlotte plaza.

    3596 Tamiami Trl, Port Charlotte, FL 33952
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    Port Charlotte Commercial Space Available
    Contact for pricing
    219,978 SF

    Port Charlotte Commercial Space Available

    5529 SF commercial space for lease in Port Charlotte.

    1032 Tamiami Trl, Port Charlotte, FL 33953
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    Port Charlotte Commercial Space Available
    Contact for pricing
    219,978 SF

    Port Charlotte Commercial Space Available

    Commercial space for lease in Murdock Town Center.

    1032 Tamiami Trl, Port Charlotte, FL 33953
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    Port Charlotte Office Space Available
    Contact for pricing
    219,978 SF

    Port Charlotte Office Space Available

    Office space for lease in a prime Port Charlotte location.

    1032 Tamiami Trl, Port Charlotte, FL 33953
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    Class A Medical Suite
    Contact for pricing
    433,422 SF

    Class A Medical Suite

    Medical suite for lease in Murdock Executive Center.

    18316 Murdock Cir, Port Charlotte, FL 33948
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    Port Charlotte Industrial Building For Lease
    Contact for pricing
    43,560 SF

    Port Charlotte Industrial Building For Lease

    14,128 SF industrial building with office space for lease.

    1242 Market Cir, Port Charlotte, FL 33953
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    Port Charlotte Office Space Available
    Contact for pricing
    219,978 SF

    Port Charlotte Office Space Available

    6451 SF office space in Murdock Town Center.

    1032 Tamiami Trl, Port Charlotte, FL 33953
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    Medical Suite in Murdock Center
    $18 SF/Yr
    8,712 SF

    Medical Suite in Murdock Center

    Class A medical office space for lease in Port Charlotte.

    18350 Murdock Cir, Port Charlotte, FL 33948
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    Remodeled Retail Space on US41
    $20 SF/Yr
    1,050 SF

    Remodeled Retail Space on US41

    Recently remodeled retail/flexible space in Charlotte Harbor on high-traffic US41.

    4560 Tamiami Trl, Port Charlotte, FL 33980
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    Silvestre Professional Center: Port Charlotte
    $15 SF/Yr
    15,450 SF

    Silvestre Professional Center: Port Charlotte

    Prime Medical & Office Space, US-41

    3524 Tamiami Trl, Port Charlotte, FL 33952
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    Harborview Road Flex Space Investment
    $14 SF/Yr
    3,585 SF

    Harborview Road Flex Space Investment

    Prime Port Charlotte Flex Space, 3,585 SF

    23263 Harborview Rd, Port Charlotte, FL 33980
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    Tamiami Trail Medical Office Space
    $20 SF/Yr
    5,600 SF

    Tamiami Trail Medical Office Space

    5,600 sq ft Medical Office Building

    3221 Tamiami Trl, Port Charlotte, FL 33952
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    Bayshore Village Retail Center
    Contact for pricing
    55,160 SF

    Bayshore Village Retail Center

    Port Charlotte Retail Space Available

    4265 Tamiami Trl, Port Charlotte, FL 33980
    View details

    Port Charlotte, FL Commercial Real Estate Leasing Opportunities Market Analysis

    Explore Commercial Real Estate leasing options in Port Charlotte, FL with 129 listings featured on our commercial real estate exchange. The current inventory includes 13,458,471,840 square feet of properties with an estimated lease value of $2,318 /Mo.

    Estimated lease rates for Commercial Real Estate in Port Charlotte, FL begin at $5 SF/Yr, with an average of $66 SF/Yr and extend to $1,742 /Mo.

    In Port Charlotte, FL, current lease rates show:

    • Office Properties & Spaces positioned at $18
    • Retail properties measuring $17
    • Individual retail properties assessed at $16
    • Retail space calculated at $16
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    Browse Commercial real estate for Lease Near Port Charlotte, FL

    Popular Searches in Port Charlotte, FL

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    Most Searched ZIP Codes in Port Charlotte, FL

    • 33952
    • 33948
    • 33953
    • 33954
    • 33980
    • 33981
    • 80513

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